FDB94_GIBM7
ID FDB94_GIBM7 Reviewed; 757 AA.
AC W7MVT8; W7MAD8;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 43.
DE RecName: Full=Transcription factor FVEG_08294 {ECO:0000303|PubMed:26808652};
DE AltName: Full=Fusarium detoxification of benzoxazolinone cluster 1 protein FVEG_08294 {ECO:0000303|PubMed:26808652};
DE Short=FDB1 cluster protein FVEG_08294 {ECO:0000303|PubMed:26808652};
GN ORFNames=FVEG_08294;
OS Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS fungus) (Fusarium verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=334819;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M3125 / FGSC 7600;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [2]
RP FUNCTION.
RX PubMed=11876429; DOI=10.1094/mpmi.2002.15.2.91;
RA Glenn A.E., Gold S.E., Bacon C.W.;
RT "Fdb1 and Fdb2, Fusarium verticillioides loci necessary for detoxification
RT of preformed antimicrobials from corn.";
RL Mol. Plant Microbe Interact. 15:91-101(2002).
RN [3]
RP FUNCTION, AND INDUCTION.
RX PubMed=26808652; DOI=10.1371/journal.pone.0147486;
RA Glenn A.E., Davis C.B., Gao M., Gold S.E., Mitchell T.R., Proctor R.H.,
RA Stewart J.E., Snook M.E.;
RT "Two horizontally transferred xenobiotic resistance gene clusters
RT associated with detoxification of benzoxazolinones by Fusarium species.";
RL PLoS ONE 11:e0147486-e0147486(2016).
CC -!- FUNCTION: Transcription factor; part of the Fusarium detoxification of
CC benzoxazolinone cluster 1 (FDB1) involved in the degradation of
CC benzoxazolinones produced by the host plant (PubMed:26808652). Maize,
CC wheat, and rye produce the 2 benzoxazinone phytoanticipins 2,4-dihy-
CC droxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) and 2,4-dihydroxy-1,4-
CC benzoxazin-3-one (DIBOA) that, due to their inherent instability once
CC released, spontaneously degrade to the more stable corresponding
CC benzoxazolinones, 6-methoxy-2-benzoxazolinone (MBOA) and 2-
CC benzoxazolinone (BOA), respectively (PubMed:11876429). Might be
CC involved in the regulation of the expression of the FDB1 cluster genes
CC (Probable). {ECO:0000269|PubMed:11876429, ECO:0000269|PubMed:26808652,
CC ECO:0000305|PubMed:26808652}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC -!- INDUCTION: Expression is induced in response to 2-benzoxasolinone (BOA)
CC exposure. {ECO:0000269|PubMed:26808652}.
CC -!- MISCELLANEOUS: Fusarium verticillioides possesses 2 unlinked loci, FDB1
CC and FDB2, necessary for detoxification of antimicrobial compounds
CC produced by maize, including 2-benzoxazolinone (BOA) (Probable). The
CC FDB2 cluster arose as a duplication of the FDB1 cluster with
CC rearrangement and expansion by incorporating additional genes
CC (Probable). {ECO:0000305|PubMed:26808652}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EWG48583.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; DS022252; EWG48583.1; ALT_INIT; Genomic_DNA.
DR EMBL; DS022252; EWG48582.1; -; Genomic_DNA.
DR RefSeq; XP_018754773.1; XM_018897186.1.
DR RefSeq; XP_018754774.1; XM_018897187.1.
DR GeneID; 30066036; -.
DR KEGG; fvr:FVEG_08294; -.
DR VEuPathDB; FungiDB:FVEG_08294; -.
DR eggNOG; ENOG502RD0D; Eukaryota.
DR OrthoDB; 1285920at2759; -.
DR Proteomes; UP000009096; Chromosome 10.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00906; Fungal_trans; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..757
FT /note="Transcription factor FVEG_08294"
FT /id="PRO_0000454605"
FT DNA_BIND 24..51
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 112..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 757 AA; 82928 MW; 0C87E028D5CF5FCA CRC64;
MAPPSVENGS DTSTAKRRRI ALACNACRLR KSRCDGTRPS CSSCVSLTLD CQYEPGESAA
NVIVRKQYIS DLESRVYNVE QVVHRLNYFF EGHLSACATA TGNATVTAAA AQSRLPRIPS
PPAPSSSALE ETNDGSHPHA TGLEEPQDED ATTNGMAMTF VEEHTSAFFG GSSNINFTRL
LLKAVNNIRN PARRLGATVD QQHELSETNL AKASRSYTNP VAASPDTGPK AMTTLPPAQE
MDRMLDVYFK TAGTVFPFIH EESMRKTYTT CKASNWTRVR RTFLGTLNVI FATIASADQD
AIPSARERQE RSNIFFKRAT ALCSELSKQV ISIEIVQYLV LVVIHCQGAQ RSVQAWNILG
LAVRSAMALG LHSAQAREGL DELQAEYSRR TWVVIYCMDK VLSVAFGRPA IIPDEYMLDQ
PSSSSEVAMP TPDSAGTGVD IPGDFLAVSF RLHQIMNGSL RQQYGGNVHT AEPEPDDMMS
LQASGQLRKE LRAWSASLPP YLRLCEPKAK IPSENTSVNR LRVILTLRYH NINMLIHRPL
LCSTIRHLFL GGNSVSIDNS SYIIQLAMGE AHESLRSAQH TIELVHTIIK ADPSGSNNLG
VAYFTLHYVF TASLVVLGRI LWAQHGQGAA ADETALAMCK SLLGQVETIF QLLDHDNSLV
YSCSRYINNM LEVCTAQDAI VAVQNAESGD SSAHQPPSSL AAKQLETMMH LGMGDMEMFQ
AYSSQIYDPA LSEGLDTSSV EAATARNTDW ENSFWAM
