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AIMP_BPPHT
ID   AIMP_BPPHT              Reviewed;          43 AA.
AC   P0DOE2;
DT   15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 1.
DT   10-FEB-2021, entry version 16.
DE   RecName: Full=Protein AimP {ECO:0000303|PubMed:28099413};
DE   Contains:
DE     RecName: Full=Arbitrium peptide {ECO:0000303|PubMed:28099413};
DE   Flags: Precursor;
GN   Name=aimP; OrderedLocusNames=phi3T_90;
OS   Bacillus phage phi3T (Bacteriophage phi-3T).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae; Spbetavirus; unclassified Spbetavirus.
OX   NCBI_TaxID=10736;
OH   NCBI_TaxID=1423; Bacillus subtilis.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION,
RP   PROTEOLYTIC CLEAVAGE, AND SUBUNIT.
RX   PubMed=28099413; DOI=10.1038/nature21049;
RA   Erez Z., Steinberger-Levy I., Shamir M., Doron S., Stokar-Avihail A.,
RA   Peleg Y., Melamed S., Leavitt A., Savidor A., Albeck S., Amitai G.,
RA   Sorek R.;
RT   "Communication between viruses guides lysis-lysogeny decisions.";
RL   Nature 541:488-493(2017).
CC   -!- FUNCTION: [Protein AimP]: Part of the latency-replication switch system
CC       which decides at the onset of infection whether to replicate and lyse
CC       the host or to lysogenize (latency) and keep the host viable.
CC       {ECO:0000269|PubMed:28099413}.
CC   -!- FUNCTION: [Arbitrium peptide]: Peptide which is released by the
CC       infected host bacteria and acts as a communication agent that affects
CC       the latency versus replication (lysogeny-lysis) decision for any new
CC       infecting virus from the same specie. High concentration of arbitrium
CC       peptide results in increased lysogeny in the upcoming viruses. The
CC       arbitrium peptide is secreted by infected bacteria and, after several
CC       cycles of infection, accumulates in the extracellular medium. When a
CC       virus from the same specie subsequently infects an uninfected bacterium
CC       which has internalized the peptide via its OPP transporter, the peptide
CC       will binds to the viral AimR transcriptional regulator and prevents
CC       AimR transcriptional activation of the aimX locus. Inhibition of aimX
CC       transcription promotes lysogeny. {ECO:0000269|PubMed:28099413}.
CC   -!- SUBUNIT: [Arbitrium peptide]: Interacts with the viral AimR
CC       transcriptional regulator; this interaction changes the oligomeric
CC       state of AimR from an active dimer to an inactive monomer leading to
CC       lysogeny. {ECO:0000269|PubMed:28099413}.
CC   -!- SUBCELLULAR LOCATION: [Arbitrium peptide]: Secreted
CC       {ECO:0000269|PubMed:28099413}.
CC   -!- PTM: [Protein AimP]: Cleaved by host extracellular proteases, thereby
CC       releasing the mature arbitrium peptide. {ECO:0000269|PubMed:28099413}.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=Between you and me - Issue
CC       190 of April 2017;
CC       URL="https://web.expasy.org/spotlight/back_issues/190/";
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DR   EMBL; KY030782; APD21233.1; -; Genomic_DNA.
DR   Proteomes; UP000188400; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0098689; P:latency-replication decision; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Latency-replication decision; Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..43
FT                   /note="Protein AimP"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000439252"
FT   PEPTIDE         38..43
FT                   /note="Arbitrium peptide"
FT                   /evidence="ECO:0000269|PubMed:28099413"
FT                   /id="PRO_0000439253"
FT   SITE            37..38
FT                   /note="Cleavage; by host"
FT                   /evidence="ECO:0000269|PubMed:28099413"
SQ   SEQUENCE   43 AA;  4343 MW;  0EBF3F276E6767F5 CRC64;
     MKKVFFGLVI LTALAISFVA GQQSVSTASA SDEVTVASAI RGA
 
 
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