ID   AIMP_BPSPB              Reviewed;          41 AA.
AC   O64095;
DT   15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   12-AUG-2020, entry version 44.
DE   RecName: Full=Protein AimP {ECO:0000250|UniProtKB:P0DOE2};
DE   AltName: Full=YopL protein;
DE   Contains:
DE     RecName: Full=Arbitrium peptide {ECO:0000250|UniProtKB:P0DOE2};
DE   Flags: Precursor;
GN   Name=aimP {ECO:0000250|UniProtKB:P0DOE2}; Synonyms=yopL;
OS   Bacillus phage SPbeta (Bacillus phage SPBc2) (Bacteriophage SP-beta).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae; Spbetavirus.
OX   NCBI_TaxID=66797;
OH   NCBI_TaxID=1408; Bacillus pumilus (Bacillus mesentericus).
OH   NCBI_TaxID=1423; Bacillus subtilis.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9465078; DOI=10.1073/pnas.95.4.1692;
RA   Lazarevic V., Soldo B., Duesterhoeft A., Hilbert H., Maueel C.,
RA   Karamata D.;
RT   "Introns and intein coding sequence in the ribonucleotide reductase genes
RT   of Bacillus subtilis temperate bacteriophage SPbeta.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:1692-1697(1998).
CC   -!- FUNCTION: [Protein AimP]: Part of the latency-replication switch system
CC       which decides at the onset of infection whether to replicate and lyse
CC       the host or to lysogenize (latency) and keep the host viable.
CC       {ECO:0000250|UniProtKB:P0DOE2}.
CC   -!- FUNCTION: [Arbitrium peptide]: Peptide which is released by the
CC       infected host bacteria and acts as a communication agent that affects
CC       the latency versus replication (lysogeny-lysis) decision for any new
CC       infecting virus from the same specie. High concentration of arbitrium
CC       peptide results in increased lysogeny in the upcoming viruses. The
CC       arbitrium peptide is secreted by infected bacteria and, after several
CC       cycles of infection, accumulates in the extracellular medium. When a
CC       virus from the same specie subsequently infects an uninfected bacterium
CC       which has internalized the peptide via its OPP transporter, the peptide
CC       will binds to the viral AimR transcriptional regulator and prevents
CC       AimR transcriptional activation of the aimX locus. Inhibition of aimX
CC       transcription promotes lysogeny. {ECO:0000250|UniProtKB:P0DOE2}.
CC   -!- SUBUNIT: [Arbitrium peptide]: Interacts with the viral AimR
CC       transcriptional regulator; this interaction changes the oligomeric
CC       state of AimR from an active dimer to an inactive monomer leading to
CC       lysogeny. {ECO:0000250|UniProtKB:P0DOE2}.
CC   -!- SUBCELLULAR LOCATION: [Arbitrium peptide]: Secreted
CC       {ECO:0000250|UniProtKB:P0DOE2}.
CC   -!- PTM: [Protein AimP]: Cleaved by host extracellular proteases, thereby
CC       releasing the mature arbitrium peptide. {ECO:0000250|UniProtKB:P0DOE2}.
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DR   EMBL; AF020713; AAC13055.1; -; Genomic_DNA.
DR   PIR; T12846; T12846.
DR   RefSeq; NP_046634.1; NC_001884.1.
DR   GeneID; 1261412; -.
DR   KEGG; vg:1261412; -.
DR   Proteomes; UP000009091; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0098689; P:latency-replication decision; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Latency-replication decision; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..41
FT                   /note="Protein AimP"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000439254"
FT   PEPTIDE         36..41
FT                   /note="Arbitrium peptide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000439255"
FT   SITE            35..36
FT                   /note="Cleavage; by host"
FT                   /evidence="ECO:0000250|UniProtKB:P0DOE2"
SQ   SEQUENCE   41 AA;  4215 MW;  3A9A6DCC528F9A60 CRC64;
     MKKLIMALVI LGALGTSYIS ADSSIQQASG DYEVAGMPRG A