ID   FDHD_COREF              Reviewed;         277 AA.
AC   Q8FS66;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Sulfur carrier protein FdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN   Name=fdhD {ECO:0000255|HAMAP-Rule:MF_00187}; OrderedLocusNames=CE0538;
OS   Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189
OS   / NBRC 100395).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=196164;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395;
RX   PubMed=12840036; DOI=10.1101/gr.1285603;
RA   Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S.,
RA   Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.;
RT   "Comparative complete genome sequence analysis of the amino acid
RT   replacements responsible for the thermostability of Corynebacterium
RT   efficiens.";
RL   Genome Res. 13:1572-1579(2003).
CC   -!- FUNCTION: Required for formate dehydrogenase (FDH) activity. Acts as a
CC       sulfur carrier protein that transfers sulfur from IscS to the
CC       molybdenum cofactor prior to its insertion into FDH.
CC       {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SIMILARITY: Belongs to the FdhD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00187}.
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DR   EMBL; BA000035; BAC17348.1; -; Genomic_DNA.
DR   RefSeq; WP_006769789.1; NZ_GG700687.1.
DR   AlphaFoldDB; Q8FS66; -.
DR   SMR; Q8FS66; -.
DR   STRING; 196164.23492374; -.
DR   EnsemblBacteria; BAC17348; BAC17348; BAC17348.
DR   KEGG; cef:CE0538; -.
DR   eggNOG; COG1526; Bacteria.
DR   HOGENOM; CLU_056887_3_0_11; -.
DR   OMA; RYCAGAT; -.
DR   OrthoDB; 948173at2; -.
DR   Proteomes; UP000001409; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0097163; F:sulfur carrier activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016783; F:sulfurtransferase activity; IEA:InterPro.
DR   GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00187; FdhD; 1.
DR   InterPro; IPR016193; Cytidine_deaminase-like.
DR   InterPro; IPR003786; FdhD.
DR   PANTHER; PTHR30592; PTHR30592; 1.
DR   Pfam; PF02634; FdhD-NarQ; 1.
DR   PIRSF; PIRSF015626; FdhD; 1.
DR   SUPFAM; SSF53927; SSF53927; 1.
DR   TIGRFAMs; TIGR00129; fdhD_narQ; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Molybdenum cofactor biosynthesis; Reference proteome.
FT   CHAIN           1..277
FT                   /note="Sulfur carrier protein FdhD"
FT                   /id="PRO_0000152898"
FT   ACT_SITE        123
FT                   /note="Cysteine persulfide intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
FT   BINDING         263..268
FT                   /ligand="Mo-bis(molybdopterin guanine dinucleotide)"
FT                   /ligand_id="ChEBI:CHEBI:60539"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
SQ   SEQUENCE   277 AA;  29893 MW;  F76BBCE7199E4DC6 CRC64;
     MGRITQHLQV PRVVSTETKV FVNTRPDTIA VEEPLEIRVN GTNLTTTMRT PGHDIELVHG
     LLLAEGLIRD ASEVSTARYC AGAVGPDNQN TYNVLELDVV PANPRRELNL VSVQRNLPTS
     SACGVCGTTS IEQLMDKKGW PIEPITPDPR MIITLPEKLR ERQKMFDKTG GVHAAGLATL
     DGELLVVRED VGRHNAADKV IGHMLMNGRL PLRDTILVMS SRASFELVQK AAMAGIPGVI
     AVGAATSLAV DTARDAGMFL AGFVRGNKFN HYAGELG