ID   FDHD_CUPNH              Reviewed;         288 AA.
AC   O87816; Q0KDY0;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2001, sequence version 2.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Sulfur carrier protein FdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN   Name=fdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN   Synonyms=fdsC {ECO:0000303|PubMed:9756865}; OrderedLocusNames=H16_A0643;
OS   Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS   / H16 / Stanier 337) (Ralstonia eutropha).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337;
RX   PubMed=9756865; DOI=10.1074/jbc.273.41.26349;
RA   Oh J.I., Bowien B.;
RT   "Structural analysis of the fds operon encoding the NAD+-linked formate
RT   dehydrogenase of Ralstonia eutropha.";
RL   J. Biol. Chem. 273:26349-26360(1998).
RN   [2]
RP   SEQUENCE REVISION.
RA   Bowien B.;
RL   Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337;
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA   Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I.,
RA   Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT   eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
CC   -!- FUNCTION: Required for formate dehydrogenase (FDH) activity. Acts as a
CC       sulfur carrier protein that transfers sulfur from IscS to the
CC       molybdenum cofactor prior to its insertion into FDH.
CC       {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- INDUCTION: Induced by formate. {ECO:0000269|PubMed:9756865}.
CC   -!- SIMILARITY: Belongs to the FdhD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00187}.
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DR   EMBL; AJ223295; CAA11236.2; -; Genomic_DNA.
DR   EMBL; AM260479; CAJ91791.1; -; Genomic_DNA.
DR   AlphaFoldDB; O87816; -.
DR   SMR; O87816; -.
DR   STRING; 381666.H16_A0643; -.
DR   EnsemblBacteria; CAJ91791; CAJ91791; H16_A0643.
DR   KEGG; reh:H16_A0643; -.
DR   eggNOG; COG1526; Bacteria.
DR   HOGENOM; CLU_056887_2_0_4; -.
DR   OMA; RAFWNLK; -.
DR   Proteomes; UP000008210; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0097163; F:sulfur carrier activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016783; F:sulfurtransferase activity; IEA:InterPro.
DR   GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00187; FdhD; 1.
DR   InterPro; IPR016193; Cytidine_deaminase-like.
DR   InterPro; IPR003786; FdhD.
DR   PANTHER; PTHR30592; PTHR30592; 1.
DR   Pfam; PF02634; FdhD-NarQ; 1.
DR   PIRSF; PIRSF015626; FdhD; 1.
DR   SUPFAM; SSF53927; SSF53927; 1.
DR   TIGRFAMs; TIGR00129; fdhD_narQ; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Molybdenum cofactor biosynthesis; Reference proteome.
FT   CHAIN           1..288
FT                   /note="Sulfur carrier protein FdhD"
FT                   /id="PRO_0000152886"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        127
FT                   /note="Cysteine persulfide intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
SQ   SEQUENCE   288 AA;  30661 MW;  10932A0FE714C7CD CRC64;
     MMRCMQSPEV HPAAAGDAEP PTHSTFAVSR WRRGELMLSP DEVAEEVPVA LVYNGISHAV
     MLATPADLED FALGFSLSEG IVTRASDVYD IEIDTREHGI AVQLEIASEA FMRLKDRRRS
     LAGRTGCGLC GTESLEQVMR LPAPVRSDAS FHTDVIQAAF VQLQLRQELQ QHTGATHAAA
     WLRADGHVSL VREDVGRHNA LDKLAGALAS SGEDISSGAV LVTSRASYEM VLKTAAIGAG
     VLAAVSAPTA LAVRLAEQAS ITLAGFVRAG AHVVYAHPQR LQHEASLA