FDHD_HAEIN
ID FDHD_HAEIN Reviewed; 270 AA.
AC P44449;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Sulfur carrier protein FdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN Name=fdhD {ECO:0000255|HAMAP-Rule:MF_00187}; OrderedLocusNames=HI_0005;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Required for formate dehydrogenase (FDH) activity. Acts as a
CC sulfur carrier protein that transfers sulfur from IscS to the
CC molybdenum cofactor prior to its insertion into FDH.
CC {ECO:0000255|HAMAP-Rule:MF_00187}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00187}.
CC -!- SIMILARITY: Belongs to the FdhD family. {ECO:0000255|HAMAP-
CC Rule:MF_00187}.
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DR EMBL; L42023; AAC21684.1; -; Genomic_DNA.
DR PIR; I64041; I64041.
DR RefSeq; NP_438178.1; NC_000907.1.
DR RefSeq; WP_005649892.1; NC_000907.1.
DR AlphaFoldDB; P44449; -.
DR SMR; P44449; -.
DR STRING; 71421.HI_0005; -.
DR EnsemblBacteria; AAC21684; AAC21684; HI_0005.
DR KEGG; hin:HI_0005; -.
DR PATRIC; fig|71421.8.peg.5; -.
DR eggNOG; COG1526; Bacteria.
DR HOGENOM; CLU_056887_2_0_6; -.
DR OMA; RYCAGAT; -.
DR PhylomeDB; P44449; -.
DR BioCyc; HINF71421:G1GJ1-5-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0097163; F:sulfur carrier activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016783; F:sulfurtransferase activity; IEA:InterPro.
DR GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00187; FdhD; 1.
DR InterPro; IPR016193; Cytidine_deaminase-like.
DR InterPro; IPR003786; FdhD.
DR PANTHER; PTHR30592; PTHR30592; 1.
DR Pfam; PF02634; FdhD-NarQ; 1.
DR PIRSF; PIRSF015626; FdhD; 1.
DR SUPFAM; SSF53927; SSF53927; 1.
DR TIGRFAMs; TIGR00129; fdhD_narQ; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Molybdenum cofactor biosynthesis; Reference proteome.
FT CHAIN 1..270
FT /note="Sulfur carrier protein FdhD"
FT /id="PRO_0000152904"
FT ACT_SITE 116
FT /note="Cysteine persulfide intermediate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
FT BINDING 253..258
FT /ligand="Mo-bis(molybdopterin guanine dinucleotide)"
FT /ligand_id="ChEBI:CHEBI:60539"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
SQ SEQUENCE 270 AA; 30044 MW; F52E9CA72E4A024D CRC64;
MQCWIRQTIN FFRKTKNTEK LTALLQQKED ILAVEIPVSL VYNGISHAVM MCSPNNLEDF
ALGFSLTEGI INKPEDIYGI DVVEVCNGIE VQIELSSRKF MALKEHRRNL TGRTGCGICG
TEQLNQVYKT FPKLDCTFQF DLNLLDSCLI DLQKNQLLGC KTGATHACAF FDLYGSMLAI
YEDVGRHVAL DKLLGWHAKS GKPRGFILAS SRASYEMVQK TVACGVEMLV TISAATDLAV
TMAEKHNLTL IGFAREGKGN IYSGHLRLHN