FDHD_MYCBO
ID FDHD_MYCBO Reviewed; 276 AA.
AC P64119; A0A1R3Y2J9; Q10820; X2BMC9;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Sulfur carrier protein FdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN Name=fdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN OrderedLocusNames=BQ2027_MB2923C;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
CC -!- FUNCTION: Required for formate dehydrogenase (FDH) activity. Acts as a
CC sulfur carrier protein that transfers sulfur from IscS to the
CC molybdenum cofactor prior to its insertion into FDH.
CC {ECO:0000255|HAMAP-Rule:MF_00187}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00187}.
CC -!- SIMILARITY: Belongs to the FdhD family. {ECO:0000255|HAMAP-
CC Rule:MF_00187}.
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DR EMBL; LT708304; SIU01544.1; -; Genomic_DNA.
DR RefSeq; NP_856568.1; NC_002945.3.
DR RefSeq; WP_003414705.1; NC_002945.4.
DR AlphaFoldDB; P64119; -.
DR SMR; P64119; -.
DR EnsemblBacteria; SIU01544; SIU01544; BQ2027_MB2923C.
DR GeneID; 45426886; -.
DR PATRIC; fig|233413.5.peg.3209; -.
DR OMA; RAFWNLK; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0097163; F:sulfur carrier activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016783; F:sulfurtransferase activity; IEA:InterPro.
DR GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00187; FdhD; 1.
DR InterPro; IPR016193; Cytidine_deaminase-like.
DR InterPro; IPR003786; FdhD.
DR PANTHER; PTHR30592; PTHR30592; 1.
DR Pfam; PF02634; FdhD-NarQ; 1.
DR PIRSF; PIRSF015626; FdhD; 1.
DR SUPFAM; SSF53927; SSF53927; 1.
DR TIGRFAMs; TIGR00129; fdhD_narQ; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Molybdenum cofactor biosynthesis.
FT CHAIN 1..276
FT /note="Sulfur carrier protein FdhD"
FT /id="PRO_0000152910"
FT ACT_SITE 118
FT /note="Cysteine persulfide intermediate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
SQ SEQUENCE 276 AA; 29090 MW; C0E0255758981C61 CRC64;
MGYATAHRRV RHLSADQVIT RPETLAVEEP LEIRVNGTPV TVTMRTPGSD FELVQGFLLA
EGVVAHREDV LTVSYCGRRV EGNATGASTY NVLDVALAPG VKPPDVDVTR TFYTTSSCGV
CGKASLQAVS QVSRFAPGGD PATVAADTLK AMPDQLRRAQ KVFARTGGLH AAALFGVDGA
MLAVREDIGR HNAVDKVIGW AFERDRIPLG ASVLLVSGRA SFELTQKALM AGIPVLAAVS
APSSLAVSLA DASGITLVAF LRGDSMNVYT RADRIT