ID   FDHD_MYCPA              Reviewed;         272 AA.
AC   Q73VP7;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Sulfur carrier protein FdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN   Name=fdhD {ECO:0000255|HAMAP-Rule:MF_00187}; OrderedLocusNames=MAP_2966c;
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10;
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- FUNCTION: Required for formate dehydrogenase (FDH) activity. Acts as a
CC       sulfur carrier protein that transfers sulfur from IscS to the
CC       molybdenum cofactor prior to its insertion into FDH.
CC       {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SIMILARITY: Belongs to the FdhD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00187}.
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DR   EMBL; AE016958; AAS05283.1; -; Genomic_DNA.
DR   RefSeq; WP_003878713.1; NC_002944.2.
DR   AlphaFoldDB; Q73VP7; -.
DR   SMR; Q73VP7; -.
DR   STRING; 262316.MAP_2966c; -.
DR   PRIDE; Q73VP7; -.
DR   EnsemblBacteria; AAS05283; AAS05283; MAP_2966c.
DR   KEGG; mpa:MAP_2966c; -.
DR   PATRIC; fig|262316.17.peg.3143; -.
DR   eggNOG; COG1526; Bacteria.
DR   HOGENOM; CLU_056887_3_1_11; -.
DR   OMA; RAFWNLK; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0097163; F:sulfur carrier activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016783; F:sulfurtransferase activity; IEA:InterPro.
DR   GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00187; FdhD; 1.
DR   InterPro; IPR016193; Cytidine_deaminase-like.
DR   InterPro; IPR003786; FdhD.
DR   PANTHER; PTHR30592; PTHR30592; 1.
DR   Pfam; PF02634; FdhD-NarQ; 1.
DR   PIRSF; PIRSF015626; FdhD; 1.
DR   SUPFAM; SSF53927; SSF53927; 1.
DR   TIGRFAMs; TIGR00129; fdhD_narQ; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Molybdenum cofactor biosynthesis; Reference proteome.
FT   CHAIN           1..272
FT                   /note="Sulfur carrier protein FdhD"
FT                   /id="PRO_0000152911"
FT   ACT_SITE        114
FT                   /note="Cysteine persulfide intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
SQ   SEQUENCE   272 AA;  28736 MW;  CF71B455514D7BED CRC64;
     MQVTSRRRVT HLTAGQAIAR PETLVVEEPL EIRVGGAAVT VTMRTPGSDF ELAQGFLLTE
     GIIGAREDVH SIRYCAGCGE DGANSYNVLD VTLAAGLGRP ELDVTRNFYT TSSCGVCGKA
     SLEAVRSVSR FSPAADPATV AAATLQAMPH QLRSAQKVFD STGGLHAAAL FRADGTMLVV
     REDVGRHNAV DKVIGWALEQ QRLPLRATVL LVSGRASFEL AQKTVMAGIP VLAAVSAPSS
     LAVSLAEESG VTLVAFLRED SMNIYTRADR IG