ID   FDHD_NOCFA              Reviewed;         279 AA.
AC   Q5Z057;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Sulfur carrier protein FdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN   Name=fdhD {ECO:0000255|HAMAP-Rule:MF_00187}; OrderedLocusNames=NFA_13390;
OS   Nocardia farcinica (strain IFM 10152).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Nocardia.
OX   NCBI_TaxID=247156;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFM 10152;
RX   PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA   Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA   Shiba T., Hattori M.;
RT   "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC   -!- FUNCTION: Required for formate dehydrogenase (FDH) activity. Acts as a
CC       sulfur carrier protein that transfers sulfur from IscS to the
CC       molybdenum cofactor prior to its insertion into FDH.
CC       {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SIMILARITY: Belongs to the FdhD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00187}.
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DR   EMBL; AP006618; BAD56184.1; -; Genomic_DNA.
DR   RefSeq; WP_011207869.1; NC_006361.1.
DR   AlphaFoldDB; Q5Z057; -.
DR   SMR; Q5Z057; -.
DR   STRING; 247156.NFA_13390; -.
DR   EnsemblBacteria; BAD56184; BAD56184; NFA_13390.
DR   GeneID; 61132161; -.
DR   KEGG; nfa:NFA_13390; -.
DR   eggNOG; COG1526; Bacteria.
DR   HOGENOM; CLU_056887_3_0_11; -.
DR   OMA; RAFWNLK; -.
DR   BioCyc; NFAR247156:NFA_RS06795-MON; -.
DR   Proteomes; UP000006820; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0097163; F:sulfur carrier activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016783; F:sulfurtransferase activity; IEA:InterPro.
DR   GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00187; FdhD; 1.
DR   InterPro; IPR016193; Cytidine_deaminase-like.
DR   InterPro; IPR003786; FdhD.
DR   PANTHER; PTHR30592; PTHR30592; 1.
DR   Pfam; PF02634; FdhD-NarQ; 1.
DR   PIRSF; PIRSF015626; FdhD; 1.
DR   SUPFAM; SSF53927; SSF53927; 1.
DR   TIGRFAMs; TIGR00129; fdhD_narQ; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Molybdenum cofactor biosynthesis; Reference proteome.
FT   CHAIN           1..279
FT                   /note="Sulfur carrier protein FdhD"
FT                   /id="PRO_0000152913"
FT   ACT_SITE        112
FT                   /note="Cysteine persulfide intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
SQ   SEQUENCE   279 AA;  29554 MW;  850DBF0DC3F3E08E CRC64;
     MSGRVTARRR VVRLTPAGEI RRQDTLAVEE PLEIRIGGQS LTVTMRTPGS DIDLVHGFLL
     SENMIGAAED VVSARYCAGT DEQGRNTYNV LDVELRRPVP VRTRHVLTTG ACGLCGKTAL
     DEVRAVTRFP LPAHGVTLAA DVLADLPATL RAGQSVFQAT GGLHAAGLFT VDGTPLAVRE
     DIGRHNAVDK VIGWALRENR VPAHELVLIV SGRASFELVQ KAVMAGIPIL GAVSAPSSLA
     VDLAEEAGLT LVGFLRGETM NVYSGAHRLR SVSAGTRTA