ID   FDHD_PICTO              Reviewed;         262 AA.
AC   Q6L080;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Sulfur carrier protein FdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN   Name=fdhD {ECO:0000255|HAMAP-Rule:MF_00187}; OrderedLocusNames=PTO1037;
OS   Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC
OS   100828).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Picrophilaceae; Picrophilus.
OX   NCBI_TaxID=263820;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828;
RX   PubMed=15184674; DOI=10.1073/pnas.0401356101;
RA   Fuetterer O., Angelov A., Liesegang H., Gottschalk G., Schleper C.,
RA   Schepers B., Dock C., Antranikian G., Liebl W.;
RT   "Genome sequence of Picrophilus torridus and its implications for life
RT   around pH 0.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9091-9096(2004).
CC   -!- FUNCTION: Required for formate dehydrogenase (FDH) activity. Acts as a
CC       sulfur carrier protein that transfers sulfur from IscS to the
CC       molybdenum cofactor prior to its insertion into FDH.
CC       {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SIMILARITY: Belongs to the FdhD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00187}.
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DR   EMBL; AE017261; AAT43622.1; -; Genomic_DNA.
DR   RefSeq; WP_011177838.1; NC_005877.1.
DR   AlphaFoldDB; Q6L080; -.
DR   SMR; Q6L080; -.
DR   STRING; 263820.PTO1037; -.
DR   EnsemblBacteria; AAT43622; AAT43622; PTO1037.
DR   GeneID; 2844403; -.
DR   KEGG; pto:PTO1037; -.
DR   PATRIC; fig|263820.9.peg.1076; -.
DR   eggNOG; arCOG04358; Archaea.
DR   HOGENOM; CLU_056887_3_0_2; -.
DR   OMA; RAFWNLK; -.
DR   OrthoDB; 68783at2157; -.
DR   Proteomes; UP000000438; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0097163; F:sulfur carrier activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016783; F:sulfurtransferase activity; IEA:InterPro.
DR   GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00187; FdhD; 1.
DR   InterPro; IPR016193; Cytidine_deaminase-like.
DR   InterPro; IPR003786; FdhD.
DR   PANTHER; PTHR30592; PTHR30592; 1.
DR   Pfam; PF02634; FdhD-NarQ; 1.
DR   PIRSF; PIRSF015626; FdhD; 1.
DR   SUPFAM; SSF53927; SSF53927; 1.
DR   TIGRFAMs; TIGR00129; fdhD_narQ; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Molybdenum cofactor biosynthesis; Reference proteome.
FT   CHAIN           1..262
FT                   /note="Sulfur carrier protein FdhD"
FT                   /id="PRO_0000152938"
FT   ACT_SITE        105
FT                   /note="Cysteine persulfide intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
FT   BINDING         246..251
FT                   /ligand="Mo-bis(molybdopterin guanine dinucleotide)"
FT                   /ligand_id="ChEBI:CHEBI:60539"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
SQ   SEQUENCE   262 AA;  29224 MW;  55457E72F04AB864 CRC64;
     MMPYISKNAV IIGRDRKFIT DNVTVEEPLQ ISIENENRIY NVSVIMRTPV DDEALATGFL
     VNEGIIEPDK IIKVSKRSEN NVCVSVESFN EDLLKNRNFY VNSSCGVCGK TDIENVFIKS
     HGIVRSQSRT DHSIILGLPD KMMKNQKIFS YTGGIHAAAL FDLNGNMISI SEDIGRHNAV
     DKTIGKMILK NVYRMEDSIL QVSGRAGFEI LQKASMFGVS IVSSVSAPSS LAIDVAETFN
     ITLISFVRKN RMNIYSHPER IL