ID   FDHD_SALTY              Reviewed;         278 AA.
AC   Q8ZKS7;
DT   30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Sulfur carrier protein FdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN   Name=fdhD {ECO:0000255|HAMAP-Rule:MF_00187}; OrderedLocusNames=STM4038;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Required for formate dehydrogenase (FDH) activity. Acts as a
CC       sulfur carrier protein that transfers sulfur from IscS to the
CC       molybdenum cofactor prior to its insertion into FDH.
CC       {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SIMILARITY: Belongs to the FdhD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00187}.
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DR   EMBL; AE006468; AAL22877.1; -; Genomic_DNA.
DR   RefSeq; NP_462918.1; NC_003197.2.
DR   RefSeq; WP_001059744.1; NC_003197.2.
DR   AlphaFoldDB; Q8ZKS7; -.
DR   SMR; Q8ZKS7; -.
DR   STRING; 99287.STM4038; -.
DR   PaxDb; Q8ZKS7; -.
DR   EnsemblBacteria; AAL22877; AAL22877; STM4038.
DR   GeneID; 1255564; -.
DR   KEGG; stm:STM4038; -.
DR   PATRIC; fig|99287.12.peg.4254; -.
DR   HOGENOM; CLU_056887_2_0_6; -.
DR   OMA; RYCAGAT; -.
DR   PhylomeDB; Q8ZKS7; -.
DR   BioCyc; SENT99287:STM4038-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0097163; F:sulfur carrier activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016783; F:sulfurtransferase activity; IEA:InterPro.
DR   GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00187; FdhD; 1.
DR   InterPro; IPR016193; Cytidine_deaminase-like.
DR   InterPro; IPR003786; FdhD.
DR   PANTHER; PTHR30592; PTHR30592; 1.
DR   Pfam; PF02634; FdhD-NarQ; 1.
DR   PIRSF; PIRSF015626; FdhD; 1.
DR   SUPFAM; SSF53927; SSF53927; 1.
DR   TIGRFAMs; TIGR00129; fdhD_narQ; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Molybdenum cofactor biosynthesis; Reference proteome.
FT   CHAIN           1..278
FT                   /note="Sulfur carrier protein FdhD"
FT                   /id="PRO_0000152919"
FT   ACT_SITE        121
FT                   /note="Cysteine persulfide intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
FT   BINDING         260..265
FT                   /ligand="Mo-bis(molybdopterin guanine dinucleotide)"
FT                   /ligand_id="ChEBI:CHEBI:60539"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
SQ   SEQUENCE   278 AA;  30270 MW;  28F6302381B38915 CRC64;
     MNNILSEEVL NVTDFTTSRQ LTLWKREDLQ SPQLDDVAEE VPVALVYNGI SHVVMMASPK
     DLTHFAMGFS LSEGIIDSPR EIYGMDVVPS CNGLEVQIDL SSRRFMGLKA RRRALAGRTG
     CGVCGVEQLN DIGKPVQPLP FSQTFNLGNL DRALKHLNDF QPTGKLTGCT HAAAWVMPSG
     ELAGGHEDVG RHVALDKLLG RRATEGEEWR QGAALVSSRA SYEMVQKSAM CGVEILFAVS
     AATTLAVEVA ERCNLTLVGF CKPGRATIYT HPQRLIAD