ID   FDHD_STAAB              Reviewed;         265 AA.
AC   Q2YYR6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Sulfur carrier protein FdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN   Name=fdhD {ECO:0000255|HAMAP-Rule:MF_00187}; OrderedLocusNames=SAB2152;
OS   Staphylococcus aureus (strain bovine RF122 / ET3-1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=273036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=bovine RF122 / ET3-1;
RX   PubMed=17971880; DOI=10.1371/journal.pone.0001120;
RA   Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.;
RT   "Molecular correlates of host specialization in Staphylococcus aureus.";
RL   PLoS ONE 2:E1120-E1120(2007).
CC   -!- FUNCTION: Required for formate dehydrogenase (FDH) activity. Acts as a
CC       sulfur carrier protein that transfers sulfur from IscS to the
CC       molybdenum cofactor prior to its insertion into FDH.
CC       {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SIMILARITY: Belongs to the FdhD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00187}.
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DR   EMBL; AJ938182; CAI81841.1; -; Genomic_DNA.
DR   RefSeq; WP_001030832.1; NC_007622.1.
DR   AlphaFoldDB; Q2YYR6; -.
DR   SMR; Q2YYR6; -.
DR   KEGG; sab:SAB2152; -.
DR   HOGENOM; CLU_056887_4_1_9; -.
DR   OMA; RYCAGAT; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0097163; F:sulfur carrier activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016783; F:sulfurtransferase activity; IEA:InterPro.
DR   GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00187; FdhD; 1.
DR   InterPro; IPR016193; Cytidine_deaminase-like.
DR   InterPro; IPR003786; FdhD.
DR   PANTHER; PTHR30592; PTHR30592; 1.
DR   Pfam; PF02634; FdhD-NarQ; 1.
DR   PIRSF; PIRSF015626; FdhD; 1.
DR   SUPFAM; SSF53927; SSF53927; 1.
DR   TIGRFAMs; TIGR00129; fdhD_narQ; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Molybdenum cofactor biosynthesis.
FT   CHAIN           1..265
FT                   /note="Sulfur carrier protein FdhD"
FT                   /id="PRO_1000020825"
FT   ACT_SITE        107
FT                   /note="Cysteine persulfide intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
SQ   SEQUENCE   265 AA;  29326 MW;  23E3E9E997E1E5BF CRC64;
     MNKDVSLGQP IVRYEDGKLF NTTDQYVTEF PLTIMVNGEE FATVICSPTN LEELVIGFLA
     SEGAILKRDE LKSVLIDDSK GFAHVGLNKD LGDRFQYSTK RMIASCCGKS REFYFQNDAA
     IAKTSMSKIT LTPIQIINMM TRLQSASHIY QETGGLHNAA ISDGLTFFVH RQDIGRHNAL
     DKLYGFCIQR HITVRDKVLI FSGRISSEIL IKAAKIGVGV ILSKSAPTTL AVTLANDLNI
     TAVGFIRNGG FNIYSHPERI IDSEQ