ID   FDHD_STAAW              Reviewed;         265 AA.
AC   Q8NV95;
DT   30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Sulfur carrier protein FdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN   Name=fdhD {ECO:0000255|HAMAP-Rule:MF_00187}; Synonyms=narQ;
GN   OrderedLocusNames=MW2198;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- FUNCTION: Required for formate dehydrogenase (FDH) activity. Acts as a
CC       sulfur carrier protein that transfers sulfur from IscS to the
CC       molybdenum cofactor prior to its insertion into FDH.
CC       {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SIMILARITY: Belongs to the FdhD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00187}.
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DR   EMBL; BA000033; BAB96063.1; -; Genomic_DNA.
DR   RefSeq; WP_001030825.1; NC_003923.1.
DR   AlphaFoldDB; Q8NV95; -.
DR   SMR; Q8NV95; -.
DR   EnsemblBacteria; BAB96063; BAB96063; BAB96063.
DR   KEGG; sam:MW2198; -.
DR   HOGENOM; CLU_056887_4_1_9; -.
DR   OMA; RYCAGAT; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0097163; F:sulfur carrier activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016783; F:sulfurtransferase activity; IEA:InterPro.
DR   GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00187; FdhD; 1.
DR   InterPro; IPR016193; Cytidine_deaminase-like.
DR   InterPro; IPR003786; FdhD.
DR   PANTHER; PTHR30592; PTHR30592; 1.
DR   Pfam; PF02634; FdhD-NarQ; 1.
DR   PIRSF; PIRSF015626; FdhD; 1.
DR   SUPFAM; SSF53927; SSF53927; 1.
DR   TIGRFAMs; TIGR00129; fdhD_narQ; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Molybdenum cofactor biosynthesis.
FT   CHAIN           1..265
FT                   /note="Sulfur carrier protein FdhD"
FT                   /id="PRO_0000152927"
FT   ACT_SITE        107
FT                   /note="Cysteine persulfide intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
SQ   SEQUENCE   265 AA;  29416 MW;  81E6FFEBCE5072EB CRC64;
     MNKDVSLGQP IVRYEDGKLF NTTDQYVTEF PLTIMVNGEE FATVICSPTN LEELVIGFLA
     SEGAILKRDE LKSVLIDDSK GFAHVELNKD LGDRFQYSTK RMIASCCGKS REFYFQNDAA
     IAKTSMSKIT LTPMQIINMM TRLQSASHIY QETGGLHNAA ISDGLTFFVH RQDIGRHNAL
     DKLYGFCIQR HITVRDKVLI FSGRISSEIL IKAAKIGVGV ILSKSAPTTL AVTLANDLNI
     TAVGFIRNGG FNIYSHPERI IDSEQ