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FDHD_STRCO
ID   FDHD_STRCO              Reviewed;         282 AA.
AC   Q9ZBW0;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Sulfur carrier protein FdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN   Name=fdhD {ECO:0000255|HAMAP-Rule:MF_00187}; OrderedLocusNames=SCO6558;
GN   ORFNames=SC4B5.08c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Required for formate dehydrogenase (FDH) activity. Acts as a
CC       sulfur carrier protein that transfers sulfur from IscS to the
CC       molybdenum cofactor prior to its insertion into FDH.
CC       {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SIMILARITY: Belongs to the FdhD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00187}.
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DR   EMBL; AL939128; CAA22362.1; -; Genomic_DNA.
DR   PIR; T35000; T35000.
DR   RefSeq; NP_630639.1; NC_003888.3.
DR   RefSeq; WP_011031006.1; NZ_VNID01000002.1.
DR   AlphaFoldDB; Q9ZBW0; -.
DR   SMR; Q9ZBW0; -.
DR   STRING; 100226.SCO6558; -.
DR   GeneID; 1101997; -.
DR   KEGG; sco:SCO6558; -.
DR   PATRIC; fig|100226.15.peg.6662; -.
DR   eggNOG; COG1526; Bacteria.
DR   HOGENOM; CLU_056887_3_0_11; -.
DR   InParanoid; Q9ZBW0; -.
DR   OMA; RYCAGAT; -.
DR   PhylomeDB; Q9ZBW0; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0097163; F:sulfur carrier activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016783; F:sulfurtransferase activity; IEA:InterPro.
DR   GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00187; FdhD; 1.
DR   InterPro; IPR016193; Cytidine_deaminase-like.
DR   InterPro; IPR003786; FdhD.
DR   PANTHER; PTHR30592; PTHR30592; 1.
DR   Pfam; PF02634; FdhD-NarQ; 1.
DR   PIRSF; PIRSF015626; FdhD; 1.
DR   SUPFAM; SSF53927; SSF53927; 1.
DR   TIGRFAMs; TIGR00129; fdhD_narQ; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Molybdenum cofactor biosynthesis; Reference proteome.
FT   CHAIN           1..282
FT                   /note="Sulfur carrier protein FdhD"
FT                   /id="PRO_0000152929"
FT   ACT_SITE        115
FT                   /note="Cysteine persulfide intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
SQ   SEQUENCE   282 AA;  29825 MW;  FA2AE1FA6A1EF630 CRC64;
     MGRVTERRKV IRIRDGAVST RPDTLVAEEP LEIRLNGKPL AITMRTPGDD FALAAGFLVS
     EGVLAEQRDL QNIVYCAGAT VDGSNTYNVV DVKTAPGVRI PDITLERNVY TTSSCGLCGK
     ASLDAVRTTA RWPIADTPPV RVTPELLADL PDRLRASQRV FDRTGGLHAA ALFTEDGELV
     DVREDVGRHN AVDKLVGRAL QNADLPLSRS VLLVSGRASF ELAQKAVMAG IPVLAAVSAP
     SSLAVDLAAE TGLTLVGFLR GSSMNVYAGA DRVALRAAVG QG
 
 
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