FDHD_STRCO
ID FDHD_STRCO Reviewed; 282 AA.
AC Q9ZBW0;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Sulfur carrier protein FdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN Name=fdhD {ECO:0000255|HAMAP-Rule:MF_00187}; OrderedLocusNames=SCO6558;
GN ORFNames=SC4B5.08c;
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145;
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
CC -!- FUNCTION: Required for formate dehydrogenase (FDH) activity. Acts as a
CC sulfur carrier protein that transfers sulfur from IscS to the
CC molybdenum cofactor prior to its insertion into FDH.
CC {ECO:0000255|HAMAP-Rule:MF_00187}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00187}.
CC -!- SIMILARITY: Belongs to the FdhD family. {ECO:0000255|HAMAP-
CC Rule:MF_00187}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL939128; CAA22362.1; -; Genomic_DNA.
DR PIR; T35000; T35000.
DR RefSeq; NP_630639.1; NC_003888.3.
DR RefSeq; WP_011031006.1; NZ_VNID01000002.1.
DR AlphaFoldDB; Q9ZBW0; -.
DR SMR; Q9ZBW0; -.
DR STRING; 100226.SCO6558; -.
DR GeneID; 1101997; -.
DR KEGG; sco:SCO6558; -.
DR PATRIC; fig|100226.15.peg.6662; -.
DR eggNOG; COG1526; Bacteria.
DR HOGENOM; CLU_056887_3_0_11; -.
DR InParanoid; Q9ZBW0; -.
DR OMA; RYCAGAT; -.
DR PhylomeDB; Q9ZBW0; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0097163; F:sulfur carrier activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016783; F:sulfurtransferase activity; IEA:InterPro.
DR GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00187; FdhD; 1.
DR InterPro; IPR016193; Cytidine_deaminase-like.
DR InterPro; IPR003786; FdhD.
DR PANTHER; PTHR30592; PTHR30592; 1.
DR Pfam; PF02634; FdhD-NarQ; 1.
DR PIRSF; PIRSF015626; FdhD; 1.
DR SUPFAM; SSF53927; SSF53927; 1.
DR TIGRFAMs; TIGR00129; fdhD_narQ; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Molybdenum cofactor biosynthesis; Reference proteome.
FT CHAIN 1..282
FT /note="Sulfur carrier protein FdhD"
FT /id="PRO_0000152929"
FT ACT_SITE 115
FT /note="Cysteine persulfide intermediate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
SQ SEQUENCE 282 AA; 29825 MW; FA2AE1FA6A1EF630 CRC64;
MGRVTERRKV IRIRDGAVST RPDTLVAEEP LEIRLNGKPL AITMRTPGDD FALAAGFLVS
EGVLAEQRDL QNIVYCAGAT VDGSNTYNVV DVKTAPGVRI PDITLERNVY TTSSCGLCGK
ASLDAVRTTA RWPIADTPPV RVTPELLADL PDRLRASQRV FDRTGGLHAA ALFTEDGELV
DVREDVGRHN AVDKLVGRAL QNADLPLSRS VLLVSGRASF ELAQKAVMAG IPVLAAVSAP
SSLAVDLAAE TGLTLVGFLR GSSMNVYAGA DRVALRAAVG QG