ID   FDHD_THEVO              Reviewed;         279 AA.
AC   Q97C60;
DT   29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Sulfur carrier protein FdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN   Name=fdhD {ECO:0000255|HAMAP-Rule:MF_00187}; OrderedLocusNames=TV0245;
GN   ORFNames=TVG0258796;
OS   Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC
OS   15438 / GSS1).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1;
RX   PubMed=11121031; DOI=10.1073/pnas.97.26.14257;
RA   Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y.,
RA   Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T.,
RA   Yamamoto Y., Aramaki H., Makino K., Suzuki M.;
RT   "Archaeal adaptation to higher temperatures revealed by genomic sequence of
RT   Thermoplasma volcanium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000).
CC   -!- FUNCTION: Required for formate dehydrogenase (FDH) activity. Acts as a
CC       sulfur carrier protein that transfers sulfur from IscS to the
CC       molybdenum cofactor prior to its insertion into FDH.
CC       {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SIMILARITY: Belongs to the FdhD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00187}.
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DR   EMBL; BA000011; BAB59387.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q97C60; -.
DR   SMR; Q97C60; -.
DR   STRING; 273116.14324459; -.
DR   EnsemblBacteria; BAB59387; BAB59387; BAB59387.
DR   KEGG; tvo:TVG0258796; -.
DR   eggNOG; arCOG04358; Archaea.
DR   HOGENOM; CLU_056887_3_0_2; -.
DR   OMA; ECTELVE; -.
DR   PhylomeDB; Q97C60; -.
DR   Proteomes; UP000001017; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0097163; F:sulfur carrier activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016783; F:sulfurtransferase activity; IEA:InterPro.
DR   GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00187; FdhD; 1.
DR   InterPro; IPR016193; Cytidine_deaminase-like.
DR   InterPro; IPR003786; FdhD.
DR   PANTHER; PTHR30592; PTHR30592; 1.
DR   Pfam; PF02634; FdhD-NarQ; 1.
DR   PIRSF; PIRSF015626; FdhD; 1.
DR   SUPFAM; SSF53927; SSF53927; 1.
DR   TIGRFAMs; TIGR00129; fdhD_narQ; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Molybdenum cofactor biosynthesis.
FT   CHAIN           1..279
FT                   /note="Sulfur carrier protein FdhD"
FT                   /id="PRO_0000152943"
FT   ACT_SITE        122
FT                   /note="Cysteine persulfide intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
SQ   SEQUENCE   279 AA;  30327 MW;  3CCEAFA596AC25B2 CRC64;
     MKAATHLNGL TSHRTLKRID SYGWLEAEDQ VAQEEPLEIK FRIGSDKEKS AGIVMRTPVH
     DDWLAVGFLY SEGILHDRRW INGIEGVSIE GKAQDNIVTV NIDPRNGSFD PDYRERFVNS
     SCGICGKSTI NGIFLRMGKI KRDNIKIDPG VIVSLPVIMK GMQQLFSKTG GIHAAALFSA
     DGKPIVTAED IGRHNAVDKV VGFSLIEGID TSTLILQVSG RAGFEIVEKA AIAGIPVICS
     VSAPSSLAIE VCESLGLTLI CFVRGSSFNV YTHAERIMI