FDHD_VARPS
ID FDHD_VARPS Reviewed; 278 AA.
AC C5CP12;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Sulfur carrier protein FdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN Name=fdhD {ECO:0000255|HAMAP-Rule:MF_00187}; OrderedLocusNames=Vapar_3020;
OS Variovorax paradoxus (strain S110).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Variovorax.
OX NCBI_TaxID=543728;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S110;
RX PubMed=21183664; DOI=10.1128/jb.00925-10;
RA Han J.I., Choi H.K., Lee S.W., Orwin P.M., Kim J., Laroe S.L., Kim T.G.,
RA O'Neil J., Leadbetter J.R., Lee S.Y., Hur C.G., Spain J.C.,
RA Ovchinnikova G., Goodwin L., Han C.;
RT "Complete genome sequence of the metabolically versatile plant growth-
RT promoting endophyte, Variovorax paradoxus S110.";
RL J. Bacteriol. 193:1183-1190(2011).
CC -!- FUNCTION: Required for formate dehydrogenase (FDH) activity. Acts as a
CC sulfur carrier protein that transfers sulfur from IscS to the
CC molybdenum cofactor prior to its insertion into FDH.
CC {ECO:0000255|HAMAP-Rule:MF_00187}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00187}.
CC -!- SIMILARITY: Belongs to the FdhD family. {ECO:0000255|HAMAP-
CC Rule:MF_00187}.
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DR EMBL; CP001635; ACS19639.1; -; Genomic_DNA.
DR RefSeq; WP_012748120.1; NC_012791.1.
DR AlphaFoldDB; C5CP12; -.
DR SMR; C5CP12; -.
DR STRING; 543728.Vapar_3020; -.
DR EnsemblBacteria; ACS19639; ACS19639; Vapar_3020.
DR GeneID; 45057285; -.
DR KEGG; vap:Vapar_3020; -.
DR eggNOG; COG1526; Bacteria.
DR HOGENOM; CLU_056887_2_0_4; -.
DR OMA; RAFWNLK; -.
DR OrthoDB; 948173at2; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0097163; F:sulfur carrier activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016783; F:sulfurtransferase activity; IEA:InterPro.
DR GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00187; FdhD; 1.
DR InterPro; IPR016193; Cytidine_deaminase-like.
DR InterPro; IPR003786; FdhD.
DR PANTHER; PTHR30592; PTHR30592; 1.
DR Pfam; PF02634; FdhD-NarQ; 1.
DR PIRSF; PIRSF015626; FdhD; 1.
DR SUPFAM; SSF53927; SSF53927; 1.
DR TIGRFAMs; TIGR00129; fdhD_narQ; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Molybdenum cofactor biosynthesis.
FT CHAIN 1..278
FT /note="Sulfur carrier protein FdhD"
FT /id="PRO_1000203969"
FT ACT_SITE 117
FT /note="Cysteine persulfide intermediate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
SQ SEQUENCE 278 AA; 29071 MW; 46C6DD8248F5AF0F CRC64;
MNLSDVPLRP GSAELLPVRG VRALQAFDNR DWVAVEVPVA LEFNGIAHAV MLATPTDLAD
FALGFALSEG ILLGRNELYG VEEAYAPEGI TLKLDVASAA FARLKARRRS MAGRTGCGLC
GTESLAHVTR ALPPLPEGPA LSTRAVARGM RELASMQVLQ KVTGAVHAAA WCSAEGEALL
VREDVGRHNA LDKLVGALAR SSVPASTGFI AVTSRASFEM VQKTVAARVP LLAAVSASTS
LATAIAEDAG LTLAGFVRGD DLVIYTHPWR LNGLPANA