ID   FDHD_WOLSU              Reviewed;         286 AA.
AC   P28181;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Sulfur carrier protein FdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN   Name=fdhD {ECO:0000255|HAMAP-Rule:MF_00187}; OrderedLocusNames=WS1149;
OS   Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC
OS   11488 / FDC 602W) (Vibrio succinogenes).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Wolinella.
OX   NCBI_TaxID=273121;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1781728; DOI=10.1007/bf00290984;
RA   Bokranz M., Gutmann M., Koertner C., Kojro E., Fahrenholz F.,
RA   Lauterbach F., Kroeger A.;
RT   "Cloning and nucleotide sequence of the structural genes encoding the
RT   formate dehydrogenase of Wolinella succinogenes.";
RL   Arch. Microbiol. 156:119-128(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29543 / DSM 1740 / CCUG 13145 / JCM 31913 / LMG 7466 / NCTC
RC   11488 / FDC 602W;
RX   PubMed=14500908; DOI=10.1073/pnas.1932838100;
RA   Baar C., Eppinger M., Raddatz G., Simon J., Lanz C., Klimmek O.,
RA   Nandakumar R., Gross R., Rosinus A., Keller H., Jagtap P., Linke B.,
RA   Meyer F., Lederer H., Schuster S.C.;
RT   "Complete genome sequence and analysis of Wolinella succinogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:11690-11695(2003).
CC   -!- FUNCTION: Required for formate dehydrogenase (FDH) activity. Acts as a
CC       sulfur carrier protein that transfers sulfur from IscS to the
CC       molybdenum cofactor prior to its insertion into FDH.
CC       {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SIMILARITY: Belongs to the FdhD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00187}.
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DR   EMBL; X54057; CAA37992.1; -; Genomic_DNA.
DR   EMBL; BX571660; CAE10236.1; -; Genomic_DNA.
DR   PIR; S18216; S18216.
DR   RefSeq; WP_011139024.1; NC_005090.1.
DR   AlphaFoldDB; P28181; -.
DR   SMR; P28181; -.
DR   STRING; 273121.WS1149; -.
DR   EnsemblBacteria; CAE10236; CAE10236; WS1149.
DR   KEGG; wsu:WS1149; -.
DR   eggNOG; COG1526; Bacteria.
DR   HOGENOM; CLU_056887_4_1_7; -.
DR   OMA; WAALFDF; -.
DR   OrthoDB; 948173at2; -.
DR   Proteomes; UP000000422; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0097163; F:sulfur carrier activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016783; F:sulfurtransferase activity; IEA:InterPro.
DR   GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00187; FdhD; 1.
DR   InterPro; IPR016193; Cytidine_deaminase-like.
DR   InterPro; IPR003786; FdhD.
DR   PANTHER; PTHR30592; PTHR30592; 1.
DR   Pfam; PF02634; FdhD-NarQ; 1.
DR   PIRSF; PIRSF015626; FdhD; 1.
DR   SUPFAM; SSF53927; SSF53927; 1.
DR   TIGRFAMs; TIGR00129; fdhD_narQ; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Molybdenum cofactor biosynthesis; Reference proteome.
FT   CHAIN           1..286
FT                   /note="Sulfur carrier protein FdhD"
FT                   /id="PRO_0000152930"
FT   ACT_SITE        110
FT                   /note="Cysteine persulfide intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
FT   BINDING         247..252
FT                   /ligand="Mo-bis(molybdopterin guanine dinucleotide)"
FT                   /ligand_id="ChEBI:CHEBI:60539"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
SQ   SEQUENCE   286 AA;  31695 MW;  14205967F3A4A24B CRC64;
     MRHTDRFVKK VVIERIGDQR VLAEEEDVVI KEERISLYLN GTKLMSMMSL PSDQDAHAVG
     FLMSEGVIEK IEDLKSVQIS SDGSSVYVEA LINHENITNL FKEKTLTSGC CVGVTGNLEG
     NVLRKFIATP MQISLERIWE GMEEFEMSSH LFHETGCVHK ASLLLEDGSK ITAEDIGRHN
     AIDKVMGKAR LGRIDTEKAV LVVSGRLSME MVVKAVMHNI PMIVSRAAAT FLGIKTAQEL
     GVTLVGFARG EKMNIYTHSG RVDLRACKRK RGVTLHAPNQ SSSLLR