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AIP12_ARATH
ID   AIP12_ARATH             Reviewed;         609 AA.
AC   Q9LV35;
DT   11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 152.
DE   RecName: Full=Actin-interacting protein 1-2 {ECO:0000303|PubMed:12417710};
GN   Name=AIP1-2 {ECO:0000303|PubMed:12417710};
GN   OrderedLocusNames=At3g18060 {ECO:0000312|Araport:AT3G18060};
GN   ORFNames=MRC8.4 {ECO:0000312|EMBL:BAB02018.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA   Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT   features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT   clones.";
RL   DNA Res. 7:217-221(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=12417710; DOI=10.1105/tpc.005363;
RA   Allwood E.G., Anthony R.G., Smertenko A.P., Reichelt S., Drobak B.K.,
RA   Doonan J.H., Weeds A.G., Hussey P.J.;
RT   "Regulation of the pollen-specific actin-depolymerizing factor LlADF1.";
RL   Plant Cell 14:2915-2927(2002).
CC   -!- FUNCTION: Binds actin. Enhances the F-actin depolymerization activity
CC       of actin-depolymerizing factor (ADF) proteins.
CC       {ECO:0000250|UniProtKB:Q9ZU34}.
CC   -!- TISSUE SPECIFICITY: Expressed in leaves, stems, flower buds and
CC       flowers. {ECO:0000269|PubMed:12417710}.
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DR   EMBL; AB020749; BAB02018.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE76041.1; -; Genomic_DNA.
DR   EMBL; AY062436; AAL32514.1; -; mRNA.
DR   EMBL; AY114624; AAM47943.1; -; mRNA.
DR   RefSeq; NP_188434.2; NM_112688.6.
DR   AlphaFoldDB; Q9LV35; -.
DR   SMR; Q9LV35; -.
DR   IntAct; Q9LV35; 4.
DR   STRING; 3702.AT3G18060.1; -.
DR   PaxDb; Q9LV35; -.
DR   PRIDE; Q9LV35; -.
DR   ProteomicsDB; 244888; -.
DR   EnsemblPlants; AT3G18060.1; AT3G18060.1; AT3G18060.
DR   GeneID; 821331; -.
DR   Gramene; AT3G18060.1; AT3G18060.1; AT3G18060.
DR   KEGG; ath:AT3G18060; -.
DR   Araport; AT3G18060; -.
DR   TAIR; locus:2092742; AT3G18060.
DR   eggNOG; KOG0318; Eukaryota.
DR   HOGENOM; CLU_015246_2_0_1; -.
DR   InParanoid; Q9LV35; -.
DR   OMA; TNPAKHT; -.
DR   OrthoDB; 325552at2759; -.
DR   PhylomeDB; Q9LV35; -.
DR   PRO; PR:Q9LV35; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9LV35; baseline and differential.
DR   GO; GO:0030864; C:cortical actin cytoskeleton; IBA:GO_Central.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:TAIR.
DR   GO; GO:0005829; C:cytosol; HDA:TAIR.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0030042; P:actin filament depolymerization; IBA:GO_Central.
DR   GO; GO:0030836; P:positive regulation of actin filament depolymerization; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR011045; N2O_reductase_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 6.
DR   SMART; SM00320; WD40; 11.
DR   SUPFAM; SSF50974; SSF50974; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..609
FT                   /note="Actin-interacting protein 1-2"
FT                   /id="PRO_0000436136"
FT   REPEAT          2..42
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          54..93
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          97..141
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          142..182
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          185..224
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          230..269
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          277..318
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          322..362
FT                   /note="WD 8"
FT                   /evidence="ECO:0000255"
FT   REPEAT          445..484
FT                   /note="WD 9"
FT                   /evidence="ECO:0000255"
FT   REPEAT          489..528
FT                   /note="WD 10"
FT                   /evidence="ECO:0000255"
FT   REPEAT          532..571
FT                   /note="WD 11"
FT                   /evidence="ECO:0000255"
FT   REPEAT          576..609
FT                   /note="WD 12"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   609 AA;  66041 MW;  B3E0676D739664A8 CRC64;
     MELSETYACV PSTERGRGIL ISGNSKSDTI LYTNGRSVVT LDLNNPLKVS IYGEHAYPAT
     VARYSPNGEW IASGDVSGTV RIWGAYNDHV LKNEFKVLAG RIDDLQWSAD GMRIVASGDG
     KGKSLVRAFM WDSGSNVGEF DGHSRRVLSC AIKPTRPFRI VTCGEDFLVN FYEGPPFKFK
     LSSREHSNFV NCVRFAPDGS KFITVSSDKK GIIYDGKTCE ILGELSSDDG HKGSIYAVSW
     SPDGKQVLTV SADKSAKIWD ISDNGSGSLN TTLNCPGSSG GVDDMLVGCL WQNDHIVTVS
     LGGTISIFSA SDLDKSPFQF SGHMKNVSSL AVLKGNADYI LSGSYDGLIC KWMLGRGFCG
     KLQRTQNSQI KCFAAHEEEI VTSGYDNKIS RISYKDDQCT NEESIDIGNQ PKDLSLAPLS
     PDLLLVTFES GVVFLRDGKV VSTINLGFIV TALAVTPDGT EAVIGGQDGK LHLYSINGDS
     LTEEAVLERH RGAISVIRYS PDLSMFASAD LNREAVVWDR VSREMKLKNM LYHSARINCL
     AWSPNSTMVA TGSLDTCVIV YEVDKPASSR MTIKGAHLGG VYGLGFADDS HVVSSGEDAC
     IRVWSFTPQ
 
 
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