ID   FDHD_YERPE              Reviewed;         274 AA.
AC   Q8Z9X7; Q0W9X1; Q8CZG9;
DT   30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 2.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Sulfur carrier protein FdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN   Name=fdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN   OrderedLocusNames=YPO4060, y4079, YP_3971;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: Required for formate dehydrogenase (FDH) activity. Acts as a
CC       sulfur carrier protein that transfers sulfur from IscS to the
CC       molybdenum cofactor prior to its insertion into FDH.
CC       {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SIMILARITY: Belongs to the FdhD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00187}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM87622.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAS64111.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL590842; CAL22633.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM87622.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE017042; AAS64111.1; ALT_INIT; Genomic_DNA.
DR   PIR; AF0493; AF0493.
DR   RefSeq; WP_002209612.1; NZ_WHLN01000039.1.
DR   RefSeq; YP_002348917.1; NC_003143.1.
DR   AlphaFoldDB; Q8Z9X7; -.
DR   SMR; Q8Z9X7; -.
DR   STRING; 214092.YPO4060; -.
DR   PaxDb; Q8Z9X7; -.
DR   DNASU; 1149026; -.
DR   EnsemblBacteria; AAM87622; AAM87622; y4079.
DR   EnsemblBacteria; AAS64111; AAS64111; YP_3971.
DR   GeneID; 57974655; -.
DR   KEGG; ype:YPO4060; -.
DR   KEGG; ypk:y4079; -.
DR   KEGG; ypm:YP_3971; -.
DR   PATRIC; fig|214092.21.peg.4600; -.
DR   eggNOG; COG1526; Bacteria.
DR   HOGENOM; CLU_056887_2_0_6; -.
DR   OMA; RYCAGAT; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0097163; F:sulfur carrier activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016783; F:sulfurtransferase activity; IEA:InterPro.
DR   GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00187; FdhD; 1.
DR   InterPro; IPR016193; Cytidine_deaminase-like.
DR   InterPro; IPR003786; FdhD.
DR   PANTHER; PTHR30592; PTHR30592; 1.
DR   Pfam; PF02634; FdhD-NarQ; 1.
DR   PIRSF; PIRSF015626; FdhD; 1.
DR   SUPFAM; SSF53927; SSF53927; 1.
DR   TIGRFAMs; TIGR00129; fdhD_narQ; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Molybdenum cofactor biosynthesis; Reference proteome.
FT   CHAIN           1..274
FT                   /note="Sulfur carrier protein FdhD"
FT                   /id="PRO_0000152934"
FT   ACT_SITE        121
FT                   /note="Cysteine persulfide intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
FT   BINDING         258..263
FT                   /ligand="Mo-bis(molybdopterin guanine dinucleotide)"
FT                   /ligand_id="ChEBI:CHEBI:60539"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
FT   CONFLICT        93
FT                   /note="G -> S (in Ref. 1; CAL22633)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   274 AA;  29735 MW;  684ECCD9FAFD455C CRC64;
     MSQIKPSRLS SSAEIRGARQ LDVLQRHKLA EPQQDWLAEE VPVALVYNGI SHVVMMATPK
     DLAAFALGFS LSEGIISSPQ EIYSIEMTPG CNGIEVNIEL SSRRFAGLKE RRRAMAGRTG
     CGVCGIEQLD DIFRPITPLP FTQAFNLEHL DTALAQLKQV QPVGQLTGCT HAAAWINPEG
     ELLGGCEDVG RHVALDKLLG IRAKQPWQQG AVLVSSRASY EMVQKTAMCG AEILFAVSAA
     TTLAVEVAER CNLTLVGFSK PGRATVYTHP QRIK