ID   AIP9_SCOMU              Reviewed;          15 AA.
AC   P0DV64;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   25-MAY-2022, sequence version 1.
DT   03-AUG-2022, entry version 2.
DE   RecName: Full=Scolopendrasin-9 {ECO:0000305};
DE   AltName: Full=Scolopendrasin IX {ECO:0000303|PubMed:30279454};
OS   Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra
OS   subspinipes mutilans).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Scolopendromorpha; Scolopendridae; Scolopendra.
OX   NCBI_TaxID=2836329;
RN   [1]
RP   FUNCTION, PROBABLE AMIDATION AT LYS-15, AND SYNTHESIS.
RX   PubMed=30279454; DOI=10.1038/s41598-018-32963-5;
RA   Park Y.J., Park B., Lee M., Jeong Y.S., Lee H.Y., Sohn D.H., Song J.J.,
RA   Lee J.H., Hwang J.S., Bae Y.S.;
RT   "A novel antimicrobial peptide acting via formyl peptide receptor 2 shows
RT   therapeutic effects against rheumatoid arthritis.";
RL   Sci. Rep. 8:14664-14664(2018).
CC   -!- FUNCTION: Anti-inflammatory peptide. By activating the G-protein
CC       coupled receptor formyl peptide receptor 2 (FPR2), this peptide
CC       markedly activates neutrophils, resulting in cytosolic calcium
CC       increase, superoxide anion production, and chemotactic cellular
CC       migration. In vivo, when tested on a auto-antibody-injected model, its
CC       administration strongly blocks the clinical phenotype of rheumatoid
CC       arthritis (RA). Mechanistically, this peptide inhibits inflammatory
CC       cytokine synthesis from the joints and neutrophil recruitment into the
CC       joint area. It may serve as a novel potential therapeutic agent for the
CC       control of RA via FPR2. {ECO:0000269|PubMed:30279454}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; G-protein coupled receptor impairing toxin; Secreted; Toxin.
FT   PEPTIDE         1..15
FT                   /note="Scolopendrasin-9"
FT                   /evidence="ECO:0000305|PubMed:30279454"
FT                   /id="PRO_0000455217"
FT   MOD_RES         15
FT                   /note="Lysine amide"
FT                   /evidence="ECO:0000269|PubMed:30279454"
SQ   SEQUENCE   15 AA;  1774 MW;  16CE465596D072F9 CRC64;
     MCKYFIKIVS KSAKK