ID   AIPL1_BOVIN             Reviewed;         328 AA.
AC   Q95MP1;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Aryl-hydrocarbon-interacting protein-like 1;
GN   Name=AIPL1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000312|EMBL:AAK77954.1};
RN   [1] {ECO:0000312|EMBL:AAK77954.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina {ECO:0000269|PubMed:11420621};
RX   PubMed=11420621; DOI=10.1007/s003350020024;
RA   Sohocki M.M., Sullivan L.S., Tirpak D.L., Daiger S.P.;
RT   "Comparative analysis of aryl-hydrocarbon receptor interacting protein-like
RT   1 (Aipl1), a gene associated with inherited retinal disease in humans.";
RL   Mamm. Genome 12:566-568(2001).
RN   [2] {ECO:0000305}
RP   INTERACTION WITH NUB1.
RX   PubMed=12374762; DOI=10.1093/hmg/11.22.2723;
RA   Akey D.T., Zhu X., Dyer M., Li A., Sorensen A., Blackshaw S.,
RA   Fukuda-Kamitani T., Daiger S.P., Craft C.M., Kamitani T., Sohocki M.M.;
RT   "The inherited blindness associated protein AIPL1 interacts with the cell
RT   cycle regulator protein NUB1.";
RL   Hum. Mol. Genet. 11:2723-2733(2002).
CC   -!- FUNCTION: May be important in protein trafficking and/or protein
CC       folding and stabilization.
CC   -!- SUBUNIT: Directly interacts with NUB1. {ECO:0000269|PubMed:12374762}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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DR   EMBL; AF296410; AAK77954.1; -; mRNA.
DR   RefSeq; NP_776659.1; NM_174234.1.
DR   AlphaFoldDB; Q95MP1; -.
DR   SMR; Q95MP1; -.
DR   IntAct; Q95MP1; 1.
DR   STRING; 9913.ENSBTAP00000010954; -.
DR   PaxDb; Q95MP1; -.
DR   PRIDE; Q95MP1; -.
DR   Ensembl; ENSBTAT00000010954; ENSBTAP00000010954; ENSBTAG00000008318.
DR   GeneID; 281609; -.
DR   KEGG; bta:281609; -.
DR   CTD; 23746; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008318; -.
DR   VGNC; VGNC:50178; AIPL1.
DR   eggNOG; KOG0545; Eukaryota.
DR   GeneTree; ENSGT00390000001289; -.
DR   InParanoid; Q95MP1; -.
DR   OMA; RTTKCDE; -.
DR   OrthoDB; 897391at2759; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000008318; Expressed in retina and 9 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0001917; C:photoreceptor inner segment; IEA:Ensembl.
DR   GO; GO:0001918; F:farnesylated protein binding; IEA:Ensembl.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0007603; P:phototransduction, visible light; IEA:Ensembl.
DR   GO; GO:0018343; P:protein farnesylation; IEA:Ensembl.
DR   GO; GO:0022400; P:regulation of rhodopsin mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0001895; P:retina homeostasis; IEA:Ensembl.
DR   GO; GO:0007601; P:visual perception; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 3.10.50.40; -; 1.
DR   InterPro; IPR039663; AIP/AIPL1.
DR   InterPro; IPR031209; AIPL1.
DR   InterPro; IPR046357; PPIase_dom_sf.
DR   InterPro; IPR001179; PPIase_FKBP_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR11242; PTHR11242; 1.
DR   PANTHER; PTHR11242:SF2; PTHR11242:SF2; 1.
DR   Pfam; PF00254; FKBP_C; 1.
DR   SMART; SM00028; TPR; 2.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50293; TPR_REGION; 2.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..328
FT                   /note="Aryl-hydrocarbon-interacting protein-like 1"
FT                   /id="PRO_0000075341"
FT   DOMAIN          53..145
FT                   /note="PPIase FKBP-type"
FT   REPEAT          178..211
FT                   /note="TPR 1"
FT   REPEAT          230..263
FT                   /note="TPR 2"
FT   REPEAT          264..297
FT                   /note="TPR 3"
SQ   SEQUENCE   328 AA;  38472 MW;  B2B5E7ACF5E0A72A CRC64;
     MDATLLLNVE GIKKTILHGG TGDLPNFITG ARVTFHFRTM KCDEERTVID DSKQVGHPMH
     IIIGNMFKLE VWEILLTSMR VSEVAEFWCD TIHTGVYPIL SRSLRQMAEG KDPTEWHVHT
     CGLANMFAYH TLGYEDLDEL QKEPQPLIFI IELLQVEAPS QYQRETWNLN NQEKMQAVPI
     LHGEGNRLFK LGRYEEASNK YQEAIVCLRN LQTKEKPWEV QWLKLEKMIN TLILNYCQCL
     LKKEEYYEVL EHTSDILRHH PGIVKAYYVR ARAHAEVWNE AEAKADLEKV LELEPSMRKA
     VQRELRLLEN RLEEKREEER LRCRNMLG