AIPL1_MOUSE
ID AIPL1_MOUSE Reviewed; 328 AA.
AC Q924K1; Q5RI54;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Aryl-hydrocarbon-interacting protein-like 1;
GN Name=Aipl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11420621; DOI=10.1007/s003350020024;
RA Sohocki M.M., Sullivan L.S., Tirpak D.L., Daiger S.P.;
RT "Comparative analysis of aryl-hydrocarbon receptor interacting protein-like
RT 1 (Aipl1), a gene associated with inherited retinal disease in humans.";
RL Mamm. Genome 12:566-568(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be important in protein trafficking and/or protein
CC folding and stabilization. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with NUB1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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DR EMBL; AF296412; AAK77956.1; -; mRNA.
DR EMBL; BX321917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466596; EDL12655.1; -; Genomic_DNA.
DR CCDS; CCDS24976.1; -.
DR RefSeq; NP_444475.2; NM_053245.2.
DR AlphaFoldDB; Q924K1; -.
DR SMR; Q924K1; -.
DR IntAct; Q924K1; 1.
DR STRING; 10090.ENSMUSP00000036279; -.
DR PhosphoSitePlus; Q924K1; -.
DR PaxDb; Q924K1; -.
DR PRIDE; Q924K1; -.
DR ProteomicsDB; 296008; -.
DR Antibodypedia; 23762; 370 antibodies from 33 providers.
DR DNASU; 114230; -.
DR Ensembl; ENSMUST00000048207; ENSMUSP00000036279; ENSMUSG00000040554.
DR GeneID; 114230; -.
DR KEGG; mmu:114230; -.
DR UCSC; uc007jxy.2; mouse.
DR CTD; 23746; -.
DR MGI; MGI:2148800; Aipl1.
DR VEuPathDB; HostDB:ENSMUSG00000040554; -.
DR eggNOG; KOG0545; Eukaryota.
DR GeneTree; ENSGT00390000001289; -.
DR HOGENOM; CLU_052244_0_0_1; -.
DR InParanoid; Q924K1; -.
DR OMA; RTTKCDE; -.
DR OrthoDB; 897391at2759; -.
DR PhylomeDB; Q924K1; -.
DR TreeFam; TF314507; -.
DR BioGRID-ORCS; 114230; 5 hits in 74 CRISPR screens.
DR PRO; PR:Q924K1; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q924K1; protein.
DR Bgee; ENSMUSG00000040554; Expressed in retinal neural layer and 15 other tissues.
DR ExpressionAtlas; Q924K1; baseline and differential.
DR Genevisible; Q924K1; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0001917; C:photoreceptor inner segment; IDA:MGI.
DR GO; GO:0001918; F:farnesylated protein binding; ISO:MGI.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IMP:MGI.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
DR GO; GO:0007603; P:phototransduction, visible light; IMP:MGI.
DR GO; GO:0018343; P:protein farnesylation; ISO:MGI.
DR GO; GO:0022400; P:regulation of rhodopsin mediated signaling pathway; IMP:MGI.
DR GO; GO:0001895; P:retina homeostasis; IMP:MGI.
DR GO; GO:0007601; P:visual perception; IEA:InterPro.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 3.10.50.40; -; 1.
DR InterPro; IPR039663; AIP/AIPL1.
DR InterPro; IPR031209; AIPL1.
DR InterPro; IPR046357; PPIase_dom_sf.
DR InterPro; IPR001179; PPIase_FKBP_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR11242; PTHR11242; 1.
DR PANTHER; PTHR11242:SF2; PTHR11242:SF2; 1.
DR Pfam; PF00254; FKBP_C; 1.
DR SMART; SM00028; TPR; 2.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..328
FT /note="Aryl-hydrocarbon-interacting protein-like 1"
FT /id="PRO_0000075344"
FT DOMAIN 53..145
FT /note="PPIase FKBP-type"
FT REPEAT 178..211
FT /note="TPR 1"
FT REPEAT 230..263
FT /note="TPR 2"
FT REPEAT 264..297
FT /note="TPR 3"
FT CONFLICT 26
FT /note="S -> N (in Ref. 1; AAK77956)"
FT /evidence="ECO:0000305"
FT CONFLICT 44
FT /note="D -> E (in Ref. 1; AAK77956)"
FT /evidence="ECO:0000305"
FT CONFLICT 151
FT /note="I -> Y (in Ref. 1; AAK77956)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 328 AA; 38212 MW; 36AA409151209D39 CRC64;
MDVSLLLNVE GVKKTILHGG TGELPSFITG SRVTFHFRTM KCDDERTVID DSKQVGQPMS
IIIGNMFKLE VWETLLTSMR LGEVAEFWCD TIHTGVYPML SRSLRQVAEG KDPTSWHVHT
CGLANMFAYH TLGYEDLDEL QKEPQPLVFL IELLQVEAPN EYQRETWNLN NEERMQAVPL
LHGEGNRLYK LGRYDQAATK YQEAIVCLRN LQTKEKPWEV EWLKLEKMIN TLILNYCQCL
LKKEEYYEVL EHTSDILRHH PGIVKAYYMR ARAHAEVWNA EEAKADLEKV LELEPSMRKA
VLRELRLLES RLADKQEEER QRCRSMLG
