ID   AIPL1_RAT               Reviewed;         328 AA.
AC   Q9JLG9;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Aryl-hydrocarbon-interacting protein-like 1;
GN   Name=Aipl1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10615133; DOI=10.1038/71732;
RA   Sohocki M.M., Bowne S.J., Sullivan L.S., Blackshaw S., Cepko C.L.,
RA   Payne A.M., Bhattacharya S.S., Khaliq S., Mehdi Q., Birch D.G.,
RA   Harrison W.R., Elder F.F.B., Heckenlively J.R., Daiger S.P.;
RT   "Mutations in a novel photoreceptor-pineal gene on 17p cause Leber
RT   congenital amaurosis.";
RL   Nat. Genet. 24:79-83(2000).
CC   -!- FUNCTION: May be important in protein trafficking and/or protein
CC       folding and stabilization. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with NUB1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in retina.
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DR   EMBL; AF180340; AAF26707.1; -; mRNA.
DR   RefSeq; NP_067601.1; NM_021590.1.
DR   RefSeq; XP_017452988.1; XM_017597499.1.
DR   AlphaFoldDB; Q9JLG9; -.
DR   SMR; Q9JLG9; -.
DR   STRING; 10116.ENSRNOP00000010533; -.
DR   PaxDb; Q9JLG9; -.
DR   Ensembl; ENSRNOT00000010533; ENSRNOP00000010533; ENSRNOG00000007889.
DR   GeneID; 59110; -.
DR   KEGG; rno:59110; -.
DR   UCSC; RGD:70906; rat.
DR   CTD; 23746; -.
DR   RGD; 70906; Aipl1.
DR   eggNOG; KOG0545; Eukaryota.
DR   GeneTree; ENSGT00390000001289; -.
DR   HOGENOM; CLU_052244_0_0_1; -.
DR   InParanoid; Q9JLG9; -.
DR   OMA; RTTKCDE; -.
DR   OrthoDB; 897391at2759; -.
DR   PhylomeDB; Q9JLG9; -.
DR   TreeFam; TF314507; -.
DR   PRO; PR:Q9JLG9; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000007889; Expressed in testis and 1 other tissue.
DR   Genevisible; Q9JLG9; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0001917; C:photoreceptor inner segment; ISO:RGD.
DR   GO; GO:0001918; F:farnesylated protein binding; ISO:RGD.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISO:RGD.
DR   GO; GO:0007603; P:phototransduction, visible light; ISO:RGD.
DR   GO; GO:0018343; P:protein farnesylation; ISO:RGD.
DR   GO; GO:0022400; P:regulation of rhodopsin mediated signaling pathway; ISO:RGD.
DR   GO; GO:0001895; P:retina homeostasis; ISO:RGD.
DR   GO; GO:0007601; P:visual perception; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 3.10.50.40; -; 1.
DR   InterPro; IPR039663; AIP/AIPL1.
DR   InterPro; IPR031209; AIPL1.
DR   InterPro; IPR046357; PPIase_dom_sf.
DR   InterPro; IPR001179; PPIase_FKBP_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR11242; PTHR11242; 1.
DR   PANTHER; PTHR11242:SF2; PTHR11242:SF2; 1.
DR   Pfam; PF00254; FKBP_C; 1.
DR   SMART; SM00028; TPR; 2.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 2.
DR   PROSITE; PS50293; TPR_REGION; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..328
FT                   /note="Aryl-hydrocarbon-interacting protein-like 1"
FT                   /id="PRO_0000075347"
FT   DOMAIN          53..145
FT                   /note="PPIase FKBP-type"
FT   REPEAT          178..211
FT                   /note="TPR 1"
FT   REPEAT          230..263
FT                   /note="TPR 2"
FT   REPEAT          264..297
FT                   /note="TPR 3"
SQ   SEQUENCE   328 AA;  38294 MW;  E9BC3A4084F64A0E CRC64;
     MDVSLLLNVE GVKKTILHGG TGELPNFITG SRVTFHFRTM KCDEERTVID DSKQVGQPMN
     IIIGNMFKLE VWETLLTSMR LGEVAEFWCD TIHTGVYPML SRSLRQVAEG KDPTSWHVHT
     CGLANMFAYH TLGYEDLDEL QKEPQPLIFL IELLQVEAPN EYQRETWNLN NEERMQAVPL
     LHGEGNRLYK LGRYDQAATK YQEAIVCLRN LQTKEKPWEV EWLKLEKMIN TLILNYCQCL
     LKKEEYYEVL EHTSDILRHH PGIVKAYYMR ARAHAEVWNA EEAKADLEKV LELEPSMRKA
     VLRELRLLES RLADKQEEER QRCRSMLG