ID   FDM3_ARATH              Reviewed;         638 AA.
AC   Q9LHB1; Q9C7B0;
DT   29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Factor of DNA methylation 3 {ECO:0000303|PubMed:22302148};
GN   Name=FDM3 {ECO:0000303|PubMed:22302148};
GN   OrderedLocusNames=At3g12550 {ECO:0000312|Araport:AT3G12550};
GN   ORFNames=T16H11.4 {ECO:0000312|EMBL:BAB02266.1},
GN   T2E22.14 {ECO:0000312|EMBL:AAG51004.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|EMBL:BAB02266.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA   Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT   features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT   clones.";
RL   DNA Res. 7:217-221(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   FUNCTION.
RX   PubMed=22302148; DOI=10.1093/nar/gks034;
RA   Xie M., Ren G., Costa-Nunes P., Pontes O., Yu B.;
RT   "A subgroup of SGS3-like proteins act redundantly in RNA-directed DNA
RT   methylation.";
RL   Nucleic Acids Res. 40:4422-4431(2012).
CC   -!- FUNCTION: Acts in association with FDM4 and FDM5 for RNA-directed DNA
CC       methylation (RdDM). {ECO:0000269|PubMed:22302148}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG51004.1; Type=Erroneous gene model prediction;
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DR   EMBL; AP002055; BAB02266.1; -; Genomic_DNA.
DR   EMBL; AC069474; AAG51004.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE75211.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE75212.1; -; Genomic_DNA.
DR   EMBL; CP002686; ANM64203.1; -; Genomic_DNA.
DR   RefSeq; NP_001189872.1; NM_001202943.2.
DR   RefSeq; NP_001326248.1; NM_001337999.1.
DR   RefSeq; NP_187861.2; NM_112090.6.
DR   AlphaFoldDB; Q9LHB1; -.
DR   SMR; Q9LHB1; -.
DR   STRING; 3702.AT3G12550.2; -.
DR   PaxDb; Q9LHB1; -.
DR   PRIDE; Q9LHB1; -.
DR   ProteomicsDB; 232078; -.
DR   EnsemblPlants; AT3G12550.1; AT3G12550.1; AT3G12550.
DR   EnsemblPlants; AT3G12550.2; AT3G12550.2; AT3G12550.
DR   EnsemblPlants; AT3G12550.4; AT3G12550.4; AT3G12550.
DR   GeneID; 820435; -.
DR   Gramene; AT3G12550.1; AT3G12550.1; AT3G12550.
DR   Gramene; AT3G12550.2; AT3G12550.2; AT3G12550.
DR   Gramene; AT3G12550.4; AT3G12550.4; AT3G12550.
DR   KEGG; ath:AT3G12550; -.
DR   Araport; AT3G12550; -.
DR   TAIR; locus:2101237; AT3G12550.
DR   eggNOG; ENOG502QRE8; Eukaryota.
DR   HOGENOM; CLU_021775_1_1_1; -.
DR   InParanoid; Q9LHB1; -.
DR   OMA; TFDHELE; -.
DR   OrthoDB; 635221at2759; -.
DR   PRO; PR:Q9LHB1; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9LHB1; baseline and differential.
DR   Genevisible; Q9LHB1; AT.
DR   GO; GO:0080188; P:gene silencing by RNA-directed DNA methylation; IGI:TAIR.
DR   CDD; cd12266; RRM_like_XS; 1.
DR   Gene3D; 3.30.70.2890; -; 1.
DR   InterPro; IPR045177; FDM1-5/IDN2.
DR   InterPro; IPR005379; FDM1-5/IDN2_XH.
DR   InterPro; IPR005380; XS_domain.
DR   InterPro; IPR038588; XS_domain_sf.
DR   InterPro; IPR005381; Znf-XS_domain.
DR   PANTHER; PTHR21596; PTHR21596; 1.
DR   Pfam; PF03469; XH; 1.
DR   Pfam; PF03468; XS; 1.
DR   Pfam; PF03470; zf-XS; 1.
PE   4: Predicted;
KW   Coiled coil; Reference proteome; RNA-mediated gene silencing.
FT   CHAIN           1..638
FT                   /note="Factor of DNA methylation 3"
FT                   /id="PRO_0000430683"
FT   COILED          318..497
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   638 AA;  74229 MW;  F2731C519A5365E3 CRC64;
     MNNKLSDFEK NLYKKLKSGK LEVKVSYRTF LCPYCPDNKK KVGLYVDILQ HASGVGNSQS
     KKRSLTEKAS HRALAKYLIK DLAHYATSTI SKRLKARTSF IPAETGDAPI IYDDAQFEKL
     VWPWKGVLVN IPTTSTEDGR SCTGESGPKL KDELIRRGFN PIRVRTVWDR FGHSGTGIVE
     FNRDWNGLQD ALVFKKAYEG DGHGKKDWLC GATDSSLYAW LANADDYYRA NILGENLRKM
     GDLKSIYRFA EEEARKDQKL LQRLNFMVEN KQYRLKKLQI KYSQDSVKLK YETEEKEKIL
     RAYSEDLTGR QQKSTDHFNR IFADHEKQKV QLESQIKELE IRKLELAKRE AENETQRKIV
     AKELEQNAAI NSYVQLSALE QQKTREKAQR LAVDHKMQKE KLHKRIAALE RQLDQKQELE
     LEVQQLKSQL SVMRLVELDS GSEIVNKVET FLRDLSETEG ELAHLNQFNQ DLVVQERKSN
     DELQEARRAL ISNLRDMGLH IGVKRMGELD TKPFMKAMRI KYCQEDLEDW AVEVIQLWEE
     YLKDPDWHPF KRIKLETAET IVEVIDEDDE KLRTLKNELG DDAYQAVANA LLEINEYNPS
     GRYISSELWN FREDRKATLE EGVNSLLEQW NQAKHLKS