ID   AIP_AMBVA               Reviewed;          59 AA.
AC   F0JA92;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 9.
DE   RecName: Full=Anti-inflammatory peptide amregulin {ECO:0000303|PubMed:27153086};
DE   AltName: Full=Hypothetical secreted peptide 866 {ECO:0000312|EMBL:DAA34740.1};
DE   Flags: Precursor;
OS   Amblyomma variegatum (Tropical bont tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Amblyomminae; Amblyomma.
OX   NCBI_TaxID=34610;
RN   [1] {ECO:0000312|EMBL:DAA34740.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Salivary gland;
RX   PubMed=21362191; DOI=10.1186/1471-2164-12-136;
RA   Ribeiro J.M., Anderson J.M., Manoukis N.C., Meng Z., Francishetti I.M.;
RT   "A further insight into the sialome of the tropical bont tick, Amblyomma
RT   variegatum.";
RL   BMC Genomics 12:136-136(2011).
RN   [2]
RP   FUNCTION.
RX   PubMed=27153086; DOI=10.3390/toxins8050133;
RA   Tian Y., Chen W., Mo G., Chen R., Fang M., Yedid G., Yan X.;
RT   "An immunosuppressant peptide from the hard tick Amblyomma variegatum.";
RL   Toxins 8:0-0(2016).
CC   -!- FUNCTION: Anti-inflammatory peptide that may facilitate successful
CC       blood feeding of ticks and may lead to immunotolerance in its host.
CC       Inhibits the secretion of inflammatory factors in rat splenocytes, such
CC       as tumor necrosis factor-alpha (TNF), interleukin-1, interleukin-8
CC       (CXCL8) and interferon-gamma (IFNG). In addition, shows strong free
CC       radical scavenging and antioxidant activities in vitro. In vivo,
CC       inhibits adjuvant-induced paw inflammation in mouse models.
CC       {ECO:0000269|PubMed:27153086}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:21362191}.
CC   -!- TISSUE SPECIFICITY: Salivary glands. {ECO:0000305|PubMed:21362191}.
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DR   EMBL; BK007793; DAA34740.1; -; mRNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..59
FT                   /note="Anti-inflammatory peptide amregulin"
FT                   /id="PRO_5003251650"
SQ   SEQUENCE   59 AA;  6612 MW;  0DE735AABBAC0251 CRC64;
     MKLHMLNMLN CLLLTVCDGH LHMHGNGATQ VFKPRLVLKC PNAAQLIQPG KLQRQLLLP