FDM4_ARATH
ID FDM4_ARATH Reviewed; 736 AA.
AC Q9LMH6;
DT 29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Factor of DNA methylation 4 {ECO:0000303|PubMed:22302148};
GN Name=FDM4 {ECO:0000303|PubMed:22302148};
GN OrderedLocusNames=At1g13790 {ECO:0000312|Araport:AT1G13790};
GN ORFNames=F16A14.3 {ECO:0000312|EMBL:AAF79392.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION.
RX PubMed=22302148; DOI=10.1093/nar/gks034;
RA Xie M., Ren G., Costa-Nunes P., Pontes O., Yu B.;
RT "A subgroup of SGS3-like proteins act redundantly in RNA-directed DNA
RT methylation.";
RL Nucleic Acids Res. 40:4422-4431(2012).
CC -!- FUNCTION: Acts in association with FDM3 and FDM5 for RNA-directed DNA
CC methylation (RdDM). {ECO:0000269|PubMed:22302148}.
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DR EMBL; AC068197; AAF79392.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29069.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60603.1; -; Genomic_DNA.
DR PIR; D86271; D86271.
DR RefSeq; NP_001318996.1; NM_001332088.1.
DR RefSeq; NP_172834.1; NM_101247.3.
DR AlphaFoldDB; Q9LMH6; -.
DR SMR; Q9LMH6; -.
DR STRING; 3702.AT1G13790.1; -.
DR iPTMnet; Q9LMH6; -.
DR PaxDb; Q9LMH6; -.
DR PRIDE; Q9LMH6; -.
DR ProteomicsDB; 230773; -.
DR EnsemblPlants; AT1G13790.1; AT1G13790.1; AT1G13790.
DR EnsemblPlants; AT1G13790.2; AT1G13790.2; AT1G13790.
DR GeneID; 837939; -.
DR Gramene; AT1G13790.1; AT1G13790.1; AT1G13790.
DR Gramene; AT1G13790.2; AT1G13790.2; AT1G13790.
DR KEGG; ath:AT1G13790; -.
DR Araport; AT1G13790; -.
DR TAIR; locus:2014754; AT1G13790.
DR eggNOG; ENOG502QWMB; Eukaryota.
DR HOGENOM; CLU_021775_1_1_1; -.
DR InParanoid; Q9LMH6; -.
DR OMA; VDFGKEW; -.
DR OrthoDB; 635221at2759; -.
DR PhylomeDB; Q9LMH6; -.
DR PRO; PR:Q9LMH6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LMH6; baseline and differential.
DR Genevisible; Q9LMH6; AT.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0080188; P:gene silencing by RNA-directed DNA methylation; IGI:TAIR.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd12266; RRM_like_XS; 1.
DR Gene3D; 3.30.70.2890; -; 1.
DR InterPro; IPR045177; FDM1-5/IDN2.
DR InterPro; IPR005379; FDM1-5/IDN2_XH.
DR InterPro; IPR005380; XS_domain.
DR InterPro; IPR038588; XS_domain_sf.
DR InterPro; IPR005381; Znf-XS_domain.
DR PANTHER; PTHR21596; PTHR21596; 1.
DR Pfam; PF03469; XH; 1.
DR Pfam; PF03468; XS; 1.
DR Pfam; PF03470; zf-XS; 1.
PE 4: Predicted;
KW Coiled coil; Methyltransferase; Reference proteome;
KW RNA-mediated gene silencing; Transferase.
FT CHAIN 1..736
FT /note="Factor of DNA methylation 4"
FT /id="PRO_0000430684"
FT REGION 80..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 360..597
FT /evidence="ECO:0000255"
FT COMPBIAS 108..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..164
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 736 AA; 85868 MW; 60757058FBF9B479 CRC64;
MYSRRELEDL EYRYYSEMKD GTRKVKISES LFRCPFCYID RKRDYQFDDL LRHASGIGGS
SRTKDGRDKA RHLALERYMR KYLRPRERPR PSPTSDVSSL PKEEFTGKWK STLSTTEEGE
FITTENSSSP HIVKAEPKFV SGDDSGRSGE ERLKFSDKPD PFFSNEDKSY PAKRPCLVSG
AKEGDEPVQR IGLSHGASFA PTYPQKLVSL GAGNGDQMYV HPWKGILANM KRTFNEKTRK
YAGESGSKIR EDLIKKGFNP HKVTPLWNGR LGFTGFAIVD FGKEWEGFRN ATMFDKHFEV
SQCGKRDHDL TRDPGDKLYG WVAKQDDYYS RTAIGDHLRK QGDLKSVSGK EAEDQRKTFT
LVSNLENTLV TKSDNLQQME SIYKQTSSVL EKRMKEKDEM INTHNEKMSI MQQTARDYLA
SIYEEHEKAS QHLEAQRKEY EDRENYLDKC QAKNKTERRK LQWQKHKNLM ATQEQNKADE
DMMRLAEQQQ REKDELRKQV RELEEKIDAE QALELEIERM RGDLQVMGHM QEGEGEDSKI
KEMIEKTKEE LKEKEEDWEY QESLYQTLVV KHGYTNDELQ DARKALIRSM RELTTRAYIG
VKRMGALDET PFKKVAKEKY PAVEADKKAE ELCSLWEEHL GDSAWHPIKV VEKDGIAKEE
LNEEDEKLQE LRKELGEEVY AAVTQALKER NEYNGSGRYI VPELWNFKQN RKASIKEGVV
YLVNSWKQKK PKPKRR
