AIP_BOVIN
ID AIP_BOVIN Reviewed; 330 AA.
AC Q7YRC1;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=AH receptor-interacting protein;
DE Short=AIP;
DE AltName: Full=Aryl-hydrocarbon receptor-interacting protein;
GN Name=AIP;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Zhou G., Li W., Yu L.;
RT "Cloning of Bos taurus aryl-hydrocarbon receptor-interacting protein
RT (Aip).";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a positive role in AHR-mediated (aromatic
CC hydrocarbon receptor) signaling, possibly by influencing its
CC receptivity for ligand and/or its nuclear targeting. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with RET in the pituitary gland; this interaction
CC prevents the formation of the AIP-survivin complex.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; AY339893; AAQ17068.1; -; mRNA.
DR STRING; 9913.ENSBTAP00000013841; -.
DR PaxDb; Q7YRC1; -.
DR PRIDE; Q7YRC1; -.
DR eggNOG; KOG0545; Eukaryota.
DR InParanoid; Q7YRC1; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; ISS:AgBase.
DR GO; GO:0006805; P:xenobiotic metabolic process; ISS:AgBase.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 3.10.50.40; -; 1.
DR InterPro; IPR031208; AIP.
DR InterPro; IPR039663; AIP/AIPL1.
DR InterPro; IPR046357; PPIase_dom_sf.
DR InterPro; IPR001179; PPIase_FKBP_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR11242; PTHR11242; 1.
DR PANTHER; PTHR11242:SF3; PTHR11242:SF3; 1.
DR Pfam; PF00254; FKBP_C; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50059; FKBP_PPIASE; 1.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..330
FT /note="AH receptor-interacting protein"
FT /id="PRO_0000075337"
FT DOMAIN 54..146
FT /note="PPIase FKBP-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00277"
FT REPEAT 179..212
FT /note="TPR 1"
FT /evidence="ECO:0000255"
FT REPEAT 231..264
FT /note="TPR 2"
FT /evidence="ECO:0000250|UniProtKB:O00170"
FT REPEAT 265..298
FT /note="TPR 3"
FT /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT ProRule:PRU00339"
FT MOD_RES 43
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00170"
SQ SEQUENCE 330 AA; 37565 MW; 6D44CE723CB0BA39 CRC64;
MADIIARLRE DGIQKRVIQE GRGALPDFQD GTKATFHYRT LCSDEEGAVL DDSRVRGKPM
ELIIGKKFKL PVWETIVRTM REGEIAQFCC DXKHVVLYPL VAKSLRNIAA GKDPLEGQRH
CCGIAQMHXH SSLGHADLDA LQQNPQPLIF DIEMLKVENP GTYQQDPWAM TDEEKAKAVP
VIHQEGNRLY REGHVKEAAA KYYDAIACLK NLQMKEQPGS PDWIQLDQQI TPLLLNYCQC
KLVAEEYYEV LDHCSSILNK YDDNVKAYFK RGKAHAAVWN AQQAQDDFAK VLQLDPAMAP
VVSRELRALE ARIRQKDEED KARFRGIFSH