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AIP_BOVIN
ID   AIP_BOVIN               Reviewed;         330 AA.
AC   Q7YRC1;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=AH receptor-interacting protein;
DE            Short=AIP;
DE   AltName: Full=Aryl-hydrocarbon receptor-interacting protein;
GN   Name=AIP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Zhou G., Li W., Yu L.;
RT   "Cloning of Bos taurus aryl-hydrocarbon receptor-interacting protein
RT   (Aip).";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a positive role in AHR-mediated (aromatic
CC       hydrocarbon receptor) signaling, possibly by influencing its
CC       receptivity for ligand and/or its nuclear targeting. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RET in the pituitary gland; this interaction
CC       prevents the formation of the AIP-survivin complex.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; AY339893; AAQ17068.1; -; mRNA.
DR   STRING; 9913.ENSBTAP00000013841; -.
DR   PaxDb; Q7YRC1; -.
DR   PRIDE; Q7YRC1; -.
DR   eggNOG; KOG0545; Eukaryota.
DR   InParanoid; Q7YRC1; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; ISS:AgBase.
DR   GO; GO:0006805; P:xenobiotic metabolic process; ISS:AgBase.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 3.10.50.40; -; 1.
DR   InterPro; IPR031208; AIP.
DR   InterPro; IPR039663; AIP/AIPL1.
DR   InterPro; IPR046357; PPIase_dom_sf.
DR   InterPro; IPR001179; PPIase_FKBP_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR11242; PTHR11242; 1.
DR   PANTHER; PTHR11242:SF3; PTHR11242:SF3; 1.
DR   Pfam; PF00254; FKBP_C; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50059; FKBP_PPIASE; 1.
DR   PROSITE; PS50005; TPR; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..330
FT                   /note="AH receptor-interacting protein"
FT                   /id="PRO_0000075337"
FT   DOMAIN          54..146
FT                   /note="PPIase FKBP-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00277"
FT   REPEAT          179..212
FT                   /note="TPR 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          231..264
FT                   /note="TPR 2"
FT                   /evidence="ECO:0000250|UniProtKB:O00170"
FT   REPEAT          265..298
FT                   /note="TPR 3"
FT                   /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT                   ProRule:PRU00339"
FT   MOD_RES         43
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O00170"
SQ   SEQUENCE   330 AA;  37565 MW;  6D44CE723CB0BA39 CRC64;
     MADIIARLRE DGIQKRVIQE GRGALPDFQD GTKATFHYRT LCSDEEGAVL DDSRVRGKPM
     ELIIGKKFKL PVWETIVRTM REGEIAQFCC DXKHVVLYPL VAKSLRNIAA GKDPLEGQRH
     CCGIAQMHXH SSLGHADLDA LQQNPQPLIF DIEMLKVENP GTYQQDPWAM TDEEKAKAVP
     VIHQEGNRLY REGHVKEAAA KYYDAIACLK NLQMKEQPGS PDWIQLDQQI TPLLLNYCQC
     KLVAEEYYEV LDHCSSILNK YDDNVKAYFK RGKAHAAVWN AQQAQDDFAK VLQLDPAMAP
     VVSRELRALE ARIRQKDEED KARFRGIFSH
 
 
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