ID   FDX2_BOVIN              Reviewed;         186 AA.
AC   Q05B51;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Ferredoxin-2, mitochondrial;
DE   AltName: Full=Adrenodoxin-like protein;
DE   AltName: Full=Ferredoxin-1-like protein;
DE   Flags: Precursor;
GN   Name=FDX2; Synonyms=FDX1L;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential for heme A and Fe/S protein biosynthesis.
CC       {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence={ECO:0000250};
CC       Note=Binds 1 [2Fe-2S] cluster. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adrenodoxin/putidaredoxin family.
CC       {ECO:0000305}.
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DR   EMBL; BC122825; AAI22826.1; -; mRNA.
DR   RefSeq; NP_001073695.1; NM_001080226.2.
DR   AlphaFoldDB; Q05B51; -.
DR   SMR; Q05B51; -.
DR   STRING; 9913.ENSBTAP00000013630; -.
DR   PaxDb; Q05B51; -.
DR   Ensembl; ENSBTAT00000013630; ENSBTAP00000013630; ENSBTAG00000010318.
DR   GeneID; 505159; -.
DR   KEGG; bta:505159; -.
DR   CTD; 112812; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010318; -.
DR   VGNC; VGNC:55209; FDX2.
DR   eggNOG; KOG3309; Eukaryota.
DR   GeneTree; ENSGT00940000161143; -.
DR   HOGENOM; CLU_082632_0_2_1; -.
DR   InParanoid; Q05B51; -.
DR   OMA; WQDPKSP; -.
DR   OrthoDB; 1380051at2759; -.
DR   TreeFam; TF354319; -.
DR   Reactome; R-BTA-1362409; Mitochondrial iron-sulfur cluster biogenesis.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000010318; Expressed in oocyte and 106 other tissues.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron transfer activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0022900; P:electron transport chain; IBA:GO_Central.
DR   GO; GO:0140647; P:P450-containing electron transport chain; IEA:InterPro.
DR   GO; GO:0051353; P:positive regulation of oxidoreductase activity; IBA:GO_Central.
DR   CDD; cd00207; fer2; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR   InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR   InterPro; IPR001055; Adrenodoxin.
DR   InterPro; IPR018298; Adrenodoxin_Fe-S_BS.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   PANTHER; PTHR23426; PTHR23426; 1.
DR   Pfam; PF00111; Fer2; 1.
DR   PRINTS; PR00355; ADRENODOXIN.
DR   SUPFAM; SSF54292; SSF54292; 1.
DR   PROSITE; PS51085; 2FE2S_FER_2; 1.
DR   PROSITE; PS00814; ADX; 1.
PE   2: Evidence at transcript level;
KW   2Fe-2S; Electron transport; Iron; Iron-sulfur; Metal-binding;
KW   Mitochondrion; Reference proteome; Transit peptide; Transport.
FT   TRANSIT         1..55
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           56..186
FT                   /note="Ferredoxin-2, mitochondrial"
FT                   /id="PRO_0000325951"
FT   DOMAIN          71..173
FT                   /note="2Fe-2S ferredoxin-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00465"
FT   BINDING         108
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00465"
FT   BINDING         114
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00465"
FT   BINDING         117
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00465"
FT   BINDING         154
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00465"
SQ   SEQUENCE   186 AA;  19947 MW;  108F58EE6061B4FA CRC64;
     MPVMAASVAW GGVNAGFLLR AARGAWWSRP GGFWGSGEAA APAIARKFRA TGSRPAGEEE
     AGGPERPGDV VNVVFVDRSG QRIPVSGRVG DNVLHLAQRH GLDLEGACEA SLACSTCHVY
     VSEDHLDLLP PPDEREDDML DMAPLLQENS RLGCQIVLTP ELEGAEFTLP KITRNFYVDG
     HVPKPH