ID   FDX2_DANRE              Reviewed;         195 AA.
AC   Q08C57;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Ferredoxin-2, mitochondrial;
DE   AltName: Full=Adrenodoxin-like protein;
DE   AltName: Full=Ferredoxin-1-like protein;
DE   Flags: Precursor;
GN   Name=fdx2; Synonyms=fdx1l; ORFNames=zgc:153554;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential for heme A and Fe/S protein biosynthesis.
CC       {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence={ECO:0000250};
CC       Note=Binds 1 [2Fe-2S] cluster. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adrenodoxin/putidaredoxin family.
CC       {ECO:0000305}.
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DR   EMBL; BC124384; AAI24385.1; -; mRNA.
DR   RefSeq; NP_001070132.1; NM_001076664.2.
DR   AlphaFoldDB; Q08C57; -.
DR   SMR; Q08C57; -.
DR   STRING; 7955.ENSDARP00000088240; -.
DR   PaxDb; Q08C57; -.
DR   PRIDE; Q08C57; -.
DR   GeneID; 767726; -.
DR   KEGG; dre:767726; -.
DR   CTD; 112812; -.
DR   ZFIN; ZDB-GENE-060929-1046; fdx2.
DR   eggNOG; KOG3309; Eukaryota.
DR   InParanoid; Q08C57; -.
DR   OrthoDB; 1380051at2759; -.
DR   PhylomeDB; Q08C57; -.
DR   Reactome; R-DRE-1362409; Mitochondrial iron-sulfur cluster biogenesis.
DR   Reactome; R-DRE-196108; Pregnenolone biosynthesis.
DR   Reactome; R-DRE-211976; Endogenous sterols.
DR   Reactome; R-DRE-2395516; Electron transport from NADPH to Ferredoxin.
DR   PRO; PR:Q08C57; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron transfer activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0022900; P:electron transport chain; IBA:GO_Central.
DR   GO; GO:0140647; P:P450-containing electron transport chain; IEA:InterPro.
DR   GO; GO:0051353; P:positive regulation of oxidoreductase activity; IBA:GO_Central.
DR   CDD; cd00207; fer2; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR   InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR   InterPro; IPR001055; Adrenodoxin.
DR   InterPro; IPR018298; Adrenodoxin_Fe-S_BS.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   PANTHER; PTHR23426; PTHR23426; 1.
DR   Pfam; PF00111; Fer2; 1.
DR   PRINTS; PR00355; ADRENODOXIN.
DR   SUPFAM; SSF54292; SSF54292; 1.
DR   PROSITE; PS51085; 2FE2S_FER_2; 1.
DR   PROSITE; PS00814; ADX; 1.
PE   2: Evidence at transcript level;
KW   2Fe-2S; Electron transport; Iron; Iron-sulfur; Metal-binding;
KW   Mitochondrion; Reference proteome; Transit peptide; Transport.
FT   TRANSIT         1..61
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           62..195
FT                   /note="Ferredoxin-2, mitochondrial"
FT                   /id="PRO_0000325954"
FT   DOMAIN          81..182
FT                   /note="2Fe-2S ferredoxin-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00465"
FT   BINDING         117
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00465"
FT   BINDING         123
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00465"
FT   BINDING         126
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00465"
FT   BINDING         163
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00465"
SQ   SEQUENCE   195 AA;  21468 MW;  B4EE7717920597D6 CRC64;
     MAAAAAVRAG VNFTQRLNRI SPVCRVCPLL RLNRCTGAAV RRAVDGFSAP SRRLRTSIGV
     CQSEDSSAPE EDAHAQEHIV NVVYIDRSGR RIPVQARVGD NVLYLAHKHG IDLEGACEAS
     LACSTCHVYV SSGHYDRLPE PEEREDDMLD MAPLLQENSR LGCQIILTPE LDGMELTLPK
     VTRNFYVDGH VPKPH