ID   FDXA1_HUMAN             Reviewed;         624 AA.
AC   Q9BRP7; A0PJW7; B4DUU2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 3.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Ferredoxin-fold anticodon-binding domain-containing protein 1;
DE            Short=FDX-ACDB domain-containing protein 1;
GN   Name=FDXACB1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ASN-87.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ASN-87.
RC   TISSUE=Lymph;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q9BRP7; Q9NPC7: MYNN; NbExp=3; IntAct=EBI-10297077, EBI-3446748;
CC       Q9BRP7; Q12933: TRAF2; NbExp=6; IntAct=EBI-10297077, EBI-355744;
CC       Q9BRP7; Q9UGJ1-2: TUBGCP4; NbExp=3; IntAct=EBI-10297077, EBI-10964469;
CC       Q9BRP7; P15622-3: ZNF250; NbExp=3; IntAct=EBI-10297077, EBI-10177272;
CC       Q9BRP7; Q8TBC5: ZSCAN18; NbExp=3; IntAct=EBI-10297077, EBI-3919096;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9BRP7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9BRP7-2; Sequence=VSP_056997;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH06136.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AK300795; BAG62454.1; -; mRNA.
DR   EMBL; AP001781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471065; EAW67156.1; -; Genomic_DNA.
DR   EMBL; BC006136; AAH06136.1; ALT_INIT; mRNA.
DR   EMBL; BC127680; AAI27681.1; -; mRNA.
DR   CCDS; CCDS44729.1; -. [Q9BRP7-1]
DR   RefSeq; NP_612387.1; NM_138378.2. [Q9BRP7-1]
DR   AlphaFoldDB; Q9BRP7; -.
DR   SMR; Q9BRP7; -.
DR   BioGRID; 124890; 14.
DR   IntAct; Q9BRP7; 9.
DR   STRING; 9606.ENSP00000260257; -.
DR   iPTMnet; Q9BRP7; -.
DR   PhosphoSitePlus; Q9BRP7; -.
DR   BioMuta; FDXACB1; -.
DR   DMDM; 296439342; -.
DR   MassIVE; Q9BRP7; -.
DR   MaxQB; Q9BRP7; -.
DR   PaxDb; Q9BRP7; -.
DR   PeptideAtlas; Q9BRP7; -.
DR   PRIDE; Q9BRP7; -.
DR   ProteomicsDB; 5217; -.
DR   ProteomicsDB; 78797; -. [Q9BRP7-1]
DR   Antibodypedia; 51439; 18 antibodies from 11 providers.
DR   DNASU; 91893; -.
DR   Ensembl; ENST00000260257.9; ENSP00000260257.4; ENSG00000255561.7. [Q9BRP7-1]
DR   GeneID; 91893; -.
DR   KEGG; hsa:91893; -.
DR   MANE-Select; ENST00000260257.9; ENSP00000260257.4; NM_138378.3; NP_612387.1.
DR   UCSC; uc001pmc.5; human. [Q9BRP7-1]
DR   CTD; 91893; -.
DR   GeneCards; FDXACB1; -.
DR   HGNC; HGNC:25110; FDXACB1.
DR   HPA; ENSG00000255561; Low tissue specificity.
DR   neXtProt; NX_Q9BRP7; -.
DR   OpenTargets; ENSG00000255561; -.
DR   PharmGKB; PA164720055; -.
DR   VEuPathDB; HostDB:ENSG00000255561; -.
DR   eggNOG; KOG2783; Eukaryota.
DR   eggNOG; KOG4174; Eukaryota.
DR   GeneTree; ENSGT00940000160701; -.
DR   HOGENOM; CLU_030162_0_0_1; -.
DR   InParanoid; Q9BRP7; -.
DR   OMA; RLYVIPR; -.
DR   OrthoDB; 1082498at2759; -.
DR   PhylomeDB; Q9BRP7; -.
DR   TreeFam; TF329685; -.
DR   PathwayCommons; Q9BRP7; -.
DR   SignaLink; Q9BRP7; -.
DR   BioGRID-ORCS; 91893; 10 hits in 1073 CRISPR screens.
DR   ChiTaRS; FDXACB1; human.
DR   Pharos; Q9BRP7; Tdark.
DR   PRO; PR:Q9BRP7; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9BRP7; protein.
DR   Bgee; ENSG00000255561; Expressed in islet of Langerhans and 100 other tissues.
DR   ExpressionAtlas; Q9BRP7; baseline and differential.
DR   Genevisible; Q9BRP7; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0070042; F:rRNA (uridine-N3-)-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0070475; P:rRNA base methylation; IBA:GO_Central.
DR   Gene3D; 3.30.70.380; -; 1.
DR   Gene3D; 3.30.930.10; -; 1.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR019446; BMT5-like.
DR   InterPro; IPR005121; Fdx_antiC-bd.
DR   InterPro; IPR036690; Fdx_antiC-bd_sf.
DR   Pfam; PF10354; DUF2431; 1.
DR   Pfam; PF03147; FDX-ACB; 1.
DR   SMART; SM00896; FDX-ACB; 1.
DR   SUPFAM; SSF54991; SSF54991; 1.
DR   PROSITE; PS51447; FDX_ACB; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..624
FT                   /note="Ferredoxin-fold anticodon-binding domain-containing
FT                   protein 1"
FT                   /id="PRO_0000325956"
FT   DOMAIN          531..624
FT                   /note="FDX-ACB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00778"
FT   VAR_SEQ         1..149
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_056997"
FT   VARIANT         28
FT                   /note="T -> A (in dbSNP:rs59164893)"
FT                   /id="VAR_062165"
FT   VARIANT         87
FT                   /note="I -> N (in dbSNP:rs611010)"
FT                   /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
FT                   /id="VAR_060321"
FT   VARIANT         475
FT                   /note="T -> P (in dbSNP:rs3168263)"
FT                   /id="VAR_060322"
SQ   SEQUENCE   624 AA;  70416 MW;  13E0C603F94B3E06 CRC64;
     MAPRRLLLVG EGNFSFAAAL SETLDQSTQL TATCLQRPAE LARDPLAWEN LQCLRERGID
     VRFGVDCTQL ADVFELHERE FDQIYFIFPH CGRKAGVAKN RELLAKFFQS CADVLAEEGE
     VHVALCRGQG GTPADKPQRE WHNSWQVVAM AALGGLILSD VYPFSCKAVA GYKCTGYRSQ
     DKSFHVEGAL NHIFTRSLPF EGSQPRIFRI KLGNQWFSFP EPEALVGKLN RGFLEAPSCH
     PIKTINEKLI AELGKVFPLK RLKCSYPLLP QEGTSVLPFW NCDFLSAAFW ISLHEDNSNS
     ESLTGGTSQD VEDFLVSFSE LSLLKNPGRD GKEEACEGTC GQAKICLRPS LLVHVQDVIE
     VPDFLSGSLH ILSGPVFQKC HILPFTMPAF HETLFILGVN QNLKDGCLQS LLDHLKGILD
     SLLTQTLPES SKLSSLVKFV LQSNGKDYMI RVKTHNFSPD CTEDLIIGSV ITSATSVIHK
     DQCFVFVSMN LDLLAMLVWC ISDWRMLWTF DNRFLKNFVP GKIEPFKSHS LYPPCYVHDV
     SFWIDQKKGF DELEFHTVAR AVSQDTIISI QFLSRFQHPK TQQVSLCYRL TYQTCDKALT
     QQQVASMQSQ FRKEIQQHLY VIPR