FDXA1_MOUSE
ID FDXA1_MOUSE Reviewed; 622 AA.
AC Q3UY23; Q14B93; Q8BUG6; Q8BZH7;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Ferredoxin-fold anticodon-binding domain-containing protein 1 homolog;
DE Short=FDX-ACDB domain-containing protein 1;
GN Name=Fdxacb1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Kidney, Olfactory bulb, and Urinary bladder;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q3UY23-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3UY23-2; Sequence=VSP_032500, VSP_032501;
CC Name=3;
CC IsoId=Q3UY23-3; Sequence=VSP_032499;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK035237; BAC28994.1; -; mRNA.
DR EMBL; AK085276; BAC39409.1; -; mRNA.
DR EMBL; AK135025; BAE22390.1; -; mRNA.
DR EMBL; BC116264; AAI16265.1; -; mRNA.
DR EMBL; BC116265; AAI16266.1; -; mRNA.
DR CCDS; CCDS23174.1; -. [Q3UY23-1]
DR RefSeq; NP_941077.2; NM_198675.2. [Q3UY23-1]
DR AlphaFoldDB; Q3UY23; -.
DR SMR; Q3UY23; -.
DR STRING; 10090.ENSMUSP00000037082; -.
DR iPTMnet; Q3UY23; -.
DR PhosphoSitePlus; Q3UY23; -.
DR MaxQB; Q3UY23; -.
DR PaxDb; Q3UY23; -.
DR PRIDE; Q3UY23; -.
DR ProteomicsDB; 272984; -. [Q3UY23-1]
DR ProteomicsDB; 272985; -. [Q3UY23-2]
DR ProteomicsDB; 272986; -. [Q3UY23-3]
DR Antibodypedia; 51439; 18 antibodies from 11 providers.
DR Ensembl; ENSMUST00000042391; ENSMUSP00000037082; ENSMUSG00000037845. [Q3UY23-1]
DR Ensembl; ENSMUST00000176335; ENSMUSP00000135658; ENSMUSG00000037845. [Q3UY23-2]
DR GeneID; 382137; -.
DR KEGG; mmu:382137; -.
DR UCSC; uc009pkq.1; mouse. [Q3UY23-1]
DR UCSC; uc009pks.1; mouse. [Q3UY23-2]
DR CTD; 91893; -.
DR MGI; MGI:3584513; Fdxacb1.
DR VEuPathDB; HostDB:ENSMUSG00000037845; -.
DR eggNOG; KOG2783; Eukaryota.
DR eggNOG; KOG4174; Eukaryota.
DR GeneTree; ENSGT00940000160701; -.
DR HOGENOM; CLU_030162_0_0_1; -.
DR InParanoid; Q3UY23; -.
DR OMA; RLYVIPR; -.
DR OrthoDB; 1082498at2759; -.
DR PhylomeDB; Q3UY23; -.
DR TreeFam; TF329685; -.
DR BioGRID-ORCS; 382137; 2 hits in 70 CRISPR screens.
DR ChiTaRS; Fdxacb1; mouse.
DR PRO; PR:Q3UY23; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q3UY23; protein.
DR Bgee; ENSMUSG00000037845; Expressed in spermatocyte and 59 other tissues.
DR ExpressionAtlas; Q3UY23; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0070042; F:rRNA (uridine-N3-)-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0070475; P:rRNA base methylation; IBA:GO_Central.
DR Gene3D; 3.30.70.380; -; 1.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR019446; BMT5-like.
DR InterPro; IPR005121; Fdx_antiC-bd.
DR InterPro; IPR036690; Fdx_antiC-bd_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF10354; DUF2431; 1.
DR Pfam; PF03147; FDX-ACB; 1.
DR SMART; SM00896; FDX-ACB; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
DR SUPFAM; SSF54991; SSF54991; 1.
DR PROSITE; PS51447; FDX_ACB; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..622
FT /note="Ferredoxin-fold anticodon-binding domain-containing
FT protein 1 homolog"
FT /id="PRO_0000325957"
FT DOMAIN 529..622
FT /note="FDX-ACB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00778"
FT VAR_SEQ 1..309
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_032499"
FT VAR_SEQ 1..149
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032500"
FT VAR_SEQ 178..230
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032501"
FT CONFLICT 506
FT /note="W -> R (in Ref. 1; BAE22390)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 622 AA; 70120 MW; 538DC5F029757D8F CRC64;
MLPRRLLLVG EGNFSFAASL IDGLDPSVSV TATGFQHRAA LEGDPVALEN LKRLRERGVE
VRFGVDCTQL SHALPADDRD FDRIYFNFPH CGRKAGVAKN RELLAKFFQS CADVLAKAGE
VHVTLCRGQG GTPADKPQRE WHNSWQVVAM AALGGFILSD VCPFSCEAVP GYKCTGYRSQ
DRPFHIEGAL TYIFTQSLPF ESCQPRTFRV RLEDRWFYFT EPEALPGKLN RRFLEASSCH
PIRTINEKLI AELGKTFPLK RLKCPLPLLS RGGPSVFLPA TCDLLPTFWI RLHEDNSCSE
FQNGEITQEM EEIPVSVSEC TLPESPVRDG CKGAQEGICG RVKLGLRPSL LVHVEAVIHS
PDFLPASLHV LSGPVFRKCH ILPFMMPAFH ETLFILGFDN NMKESCLPSL LGHLKDALGN
LLTQTLQEGS SLGTSVEFVL QPNGKDYIIH VKSLNFGPDC AENLIIGSIL TSKIVKHKHQ
CFVFVSINLD LLVMLAYGIS DWRILWTFDN RFLKRFAPGK IEHFKSYSLY PPCYVHDVSF
WVDEKKAFDE LEFHTVARAV SQDTVVSVQY RDRFQHPETR QVSLCYRLTY QTCDKALTPQ
LAAAMQSQFR KEIQRQLHVS PR
