FEA2_MAIZE
ID FEA2_MAIZE Reviewed; 613 AA.
AC Q940E8; B4G061;
DT 03-APR-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Leucine-rich repeat receptor-like protein FASCIATED EAR2;
DE AltName: Full=CLAVATA2-like protein;
DE Flags: Precursor;
GN Name=FEA2; ORFNames=ZEAMMB73_546581;
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR
RP LOCATION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. B73;
RX PubMed=11641280; DOI=10.1101/gad.208501;
RA Taguchi-Shiobara F., Yuan Z., Hake S., Jackson D.;
RT "The fasciated ear2 gene encodes a leucine-rich repeat receptor-like
RT protein that regulates shoot meristem proliferation in maize.";
RL Genes Dev. 15:2755-2766(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B73;
RX PubMed=19965430; DOI=10.1126/science.1178534;
RA Schnable P.S., Ware D., Fulton R.S., Stein J.C., Wei F., Pasternak S.,
RA Liang C., Zhang J., Fulton L., Graves T.A., Minx P., Reily A.D.,
RA Courtney L., Kruchowski S.S., Tomlinson C., Strong C., Delehaunty K.,
RA Fronick C., Courtney B., Rock S.M., Belter E., Du F., Kim K., Abbott R.M.,
RA Cotton M., Levy A., Marchetto P., Ochoa K., Jackson S.M., Gillam B.,
RA Chen W., Yan L., Higginbotham J., Cardenas M., Waligorski J., Applebaum E.,
RA Phelps L., Falcone J., Kanchi K., Thane T., Scimone A., Thane N., Henke J.,
RA Wang T., Ruppert J., Shah N., Rotter K., Hodges J., Ingenthron E.,
RA Cordes M., Kohlberg S., Sgro J., Delgado B., Mead K., Chinwalla A.,
RA Leonard S., Crouse K., Collura K., Kudrna D., Currie J., He R.,
RA Angelova A., Rajasekar S., Mueller T., Lomeli R., Scara G., Ko A.,
RA Delaney K., Wissotski M., Lopez G., Campos D., Braidotti M., Ashley E.,
RA Golser W., Kim H., Lee S., Lin J., Dujmic Z., Kim W., Talag J., Zuccolo A.,
RA Fan C., Sebastian A., Kramer M., Spiegel L., Nascimento L., Zutavern T.,
RA Miller B., Ambroise C., Muller S., Spooner W., Narechania A., Ren L.,
RA Wei S., Kumari S., Faga B., Levy M.J., McMahan L., Van Buren P.,
RA Vaughn M.W., Ying K., Yeh C.-T., Emrich S.J., Jia Y., Kalyanaraman A.,
RA Hsia A.-P., Barbazuk W.B., Baucom R.S., Brutnell T.P., Carpita N.C.,
RA Chaparro C., Chia J.-M., Deragon J.-M., Estill J.C., Fu Y., Jeddeloh J.A.,
RA Han Y., Lee H., Li P., Lisch D.R., Liu S., Liu Z., Nagel D.H., McCann M.C.,
RA SanMiguel P., Myers A.M., Nettleton D., Nguyen J., Penning B.W.,
RA Ponnala L., Schneider K.L., Schwartz D.C., Sharma A., Soderlund C.,
RA Springer N.M., Sun Q., Wang H., Waterman M., Westerman R., Wolfgruber T.K.,
RA Yang L., Yu Y., Zhang L., Zhou S., Zhu Q., Bennetzen J.L., Dawe R.K.,
RA Jiang J., Jiang N., Presting G.G., Wessler S.R., Aluru S.,
RA Martienssen R.A., Clifton S.W., McCombie W.R., Wing R.A., Wilson R.K.;
RT "The B73 maize genome: complexity, diversity, and dynamics.";
RL Science 326:1112-1115(2009).
RN [3]
RP GENOME REANNOTATION.
RG Maize Genome Sequencing Project;
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. B73;
RX PubMed=19936069; DOI=10.1371/journal.pgen.1000740;
RA Soderlund C., Descour A., Kudrna D., Bomhoff M., Boyd L., Currie J.,
RA Angelova A., Collura K., Wissotski M., Ashley E., Morrow D., Fernandes J.,
RA Walbot V., Yu Y.;
RT "Sequencing, mapping, and analysis of 27,455 maize full-length cDNAs.";
RL PLoS Genet. 5:E1000740-E1000740(2009).
RN [5]
RP MUTAGENESIS OF GLY-332; MET-367; GLY-405 AND PRO-477, AND FUNCTION.
RX PubMed=23377180; DOI=10.1038/ng.2534;
RA Bommert P., Nagasawa N.S., Jackson D.;
RT "Quantitative variation in maize kernel row number is controlled by the
RT FASCIATED EAR2 locus.";
RL Nat. Genet. 45:334-337(2013).
CC -!- FUNCTION: Receptor-like protein that regulates shoot meristem
CC proliferation. Based on additive and synergistic phenotypes of double
CC mutants, it is probable that unlike CLV1 and CLV2 in A.thaliana, FAE2
CC and TD1 do not function exclusively in a single pathway.
CC {ECO:0000269|PubMed:11641280, ECO:0000269|PubMed:23377180}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in ear primordia, vegetative apex and
CC young leaf tissues. Barely detected in expanded leaf tissues and not
CC expressed in roots. {ECO:0000269|PubMed:11641280}.
CC -!- DISRUPTION PHENOTYPE: Fasciation. Flattened and wider ears with
CC irregular rows of seeds. Thicker rachis of tassels and increased floral
CC organ numbers. {ECO:0000269|PubMed:11641280}.
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DR EMBL; AY055124; AAL17871.1; -; mRNA.
DR EMBL; CM000780; AFW62869.1; -; Genomic_DNA.
DR EMBL; BT042749; ACF87754.2; -; mRNA.
DR RefSeq; NP_001105662.1; NM_001112192.2.
DR AlphaFoldDB; Q940E8; -.
DR SMR; Q940E8; -.
DR IntAct; Q940E8; 1.
DR STRING; 4577.GRMZM2G104925_P01; -.
DR PaxDb; Q940E8; -.
DR EnsemblPlants; Zm00001eb184050_T001; Zm00001eb184050_P001; Zm00001eb184050.
DR GeneID; 542675; -.
DR Gramene; Zm00001eb184050_T001; Zm00001eb184050_P001; Zm00001eb184050.
DR KEGG; zma:542675; -.
DR MaizeGDB; 493979; -.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_000288_18_4_1; -.
DR OMA; KWSNLRY; -.
DR OrthoDB; 826997at2759; -.
DR Proteomes; UP000007305; Chromosome 4.
DR ExpressionAtlas; Q940E8; baseline and differential.
DR Genevisible; Q940E8; ZM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:EnsemblPlants.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0001653; F:peptide receptor activity; IEA:EnsemblPlants.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0009908; P:flower development; IMP:UniProtKB.
DR GO; GO:0010078; P:maintenance of root meristem identity; IEA:EnsemblPlants.
DR GO; GO:0010088; P:phloem development; IEA:EnsemblPlants.
DR GO; GO:0045595; P:regulation of cell differentiation; IEA:EnsemblPlants.
DR GO; GO:0048509; P:regulation of meristem development; IMP:UniProtKB.
DR GO; GO:0010075; P:regulation of meristem growth; IEA:EnsemblPlants.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF08263; LRRNT_2; 1.
DR SMART; SM00369; LRR_TYP; 8.
DR PROSITE; PS51450; LRR; 13.
PE 1: Evidence at protein level;
KW Cell membrane; Developmental protein; Differentiation; Glycoprotein;
KW Leucine-rich repeat; Membrane; Receptor; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..613
FT /note="Leucine-rich repeat receptor-like protein FASCIATED
FT EAR2"
FT /id="PRO_0000422039"
FT TOPO_DOM 29..573
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 574..597
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 598..613
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 79..103
FT /note="LRR 1"
FT REPEAT 104..128
FT /note="LRR 2"
FT REPEAT 130..150
FT /note="LRR 3"
FT REPEAT 151..176
FT /note="LRR 4"
FT REPEAT 178..199
FT /note="LRR 5"
FT REPEAT 202..226
FT /note="LRR 6"
FT REPEAT 227..250
FT /note="LRR 7"
FT REPEAT 251..274
FT /note="LRR 8"
FT REPEAT 276..297
FT /note="LRR 9"
FT REPEAT 298..322
FT /note="LRR 10"
FT REPEAT 324..346
FT /note="LRR 11"
FT REPEAT 347..370
FT /note="LRR 12"
FT REPEAT 372..394
FT /note="LRR 13"
FT REPEAT 435..459
FT /note="LRR 14"
FT REPEAT 460..483
FT /note="LRR 15"
FT REPEAT 484..507
FT /note="LRR 16"
FT REPEAT 508..531
FT /note="LRR 17"
FT CARBOHYD 91
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 158
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 249
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 393
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 466
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 514
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT MUTAGEN 332
FT /note="G->R: No fasciation but slightly increased number of
FT kernel rows."
FT /evidence="ECO:0000269|PubMed:23377180"
FT MUTAGEN 367
FT /note="M->I: No fasciation but slightly increased number of
FT kernel rows."
FT /evidence="ECO:0000269|PubMed:23377180"
FT MUTAGEN 405
FT /note="G->R: No fasciation but slightly increased number of
FT kernel rows."
FT /evidence="ECO:0000269|PubMed:23377180"
FT MUTAGEN 477
FT /note="P->L: No fasciation, but larger inflorescence
FT meristems and increased number of kernel rows."
FT /evidence="ECO:0000269|PubMed:23377180"
SQ SEQUENCE 613 AA; 63951 MW; 554A8A76C878A977 CRC64;
MLTATPLPHQ LLATFLLVLA SATQPAVPAS TDRAALLAFR ASLSPPSRAA LSSWSGPLSP
SWLGVSLHPA TAPAPSVTTP SVAELSLRGL NLTGVIPAAP LALLRRLRTL DLSANALSGE
LPCSLPRSLL ALDLSRNALS GAVPTCLPSS LPALRTLNLS ANFLRLPLSP RLSFPARLAA
LDLSRNAISG AVPPRIVADP DNSALLLLDL SHNRFSGEIP AGIAAVRSLQ GLFLADNQLS
GDIPPGIGNL TYLQVLDLSN NRLSGSVPAG LAGCFQLLYL QLGGNQLSGA LRPELDALAS
LKVLDLSNNK ISGEIPLPLA GCRSLEVVDL SGNEISGELS SAVAKWLSLK FLSLAGNQLS
GHLPDWMFSF PLLQWLDLSS NKFVGFIPDG GFNVSEVLNG GGGQGTPSES VLPPQLFVSA
SVDTVSWQLD LGYDVQATTG IDLSGNELCG EIPEGLVDMK GLEYLNLSCN YLAGQIPAGL
GGMGRLHTLD FSHNGLSGEV PPGIAAMTVL EVLNLSYNSL SGPLPTTKFP GALAGNPGIC
SGKGCSENAR TPEGKMEGSN HRGWLGGWHG ENGWVSLGAF CISTMTSFYV SLATLLCSSN
ARNFVFRPVR VEY
