ID   FEAR_ECOLI              Reviewed;         301 AA.
AC   Q47129; Q2MBD4;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 148.
DE   RecName: Full=Transcriptional activator FeaR;
GN   Name=feaR; Synonyms=maoB, maoR, ydbM; OrderedLocusNames=b1384, JW1379;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-6.
RX   PubMed=8631685; DOI=10.1128/jb.178.10.2941-2947.1996;
RA   Yamashita M., Azakami H., Yokoro N., Roh J.-H., Suzuki H., Kumagai H.,
RA   Murooka Y.;
RT   "maoB, a gene that encodes a positive regulator of the monoamine oxidase
RT   gene (maoA) in Escherichia coli.";
RL   J. Bacteriol. 178:2941-2947(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   PubMed=9043126; DOI=10.1099/00221287-143-2-513;
RA   Hanlon S.P., Hill T.K., Flavell M.A., Stringfellow J.M., Cooper R.A.;
RT   "2-phenylethylamine catabolism by Escherichia coli K-12: gene organization
RT   and expression.";
RL   Microbiology 143:513-518(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-104.
RC   STRAIN=W / ATCC 11105 / DSM 1900;
RX   PubMed=9109378; DOI=10.1016/s0014-5793(97)00228-7;
RA   Ferrandez A., Prieto M.A., Garcia J.L., Diaz E.;
RT   "Molecular characterization of PadA, a phenylacetaldehyde dehydrogenase
RT   from Escherichia coli.";
RL   FEBS Lett. 406:23-27(1997).
CC   -!- FUNCTION: Positive regulator of tynA/maoA and feaB/padA, the genes for
CC       2-phenylethylamine catabolism.
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DR   EMBL; D67041; BAA11058.1; -; Genomic_DNA.
DR   EMBL; X99402; CAA67779.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC74466.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76422.1; -; Genomic_DNA.
DR   EMBL; X97453; CAA66105.1; -; Genomic_DNA.
DR   PIR; C64889; C64889.
DR   RefSeq; NP_415902.1; NC_000913.3.
DR   RefSeq; WP_001067514.1; NZ_LN832404.1.
DR   AlphaFoldDB; Q47129; -.
DR   SMR; Q47129; -.
DR   BioGRID; 4262991; 7.
DR   IntAct; Q47129; 3.
DR   STRING; 511145.b1384; -.
DR   PaxDb; Q47129; -.
DR   PRIDE; Q47129; -.
DR   EnsemblBacteria; AAC74466; AAC74466; b1384.
DR   EnsemblBacteria; BAE76422; BAE76422; BAE76422.
DR   GeneID; 945941; -.
DR   KEGG; ecj:JW1379; -.
DR   KEGG; eco:b1384; -.
DR   PATRIC; fig|1411691.4.peg.888; -.
DR   EchoBASE; EB3198; -.
DR   eggNOG; COG2207; Bacteria.
DR   HOGENOM; CLU_049704_3_1_6; -.
DR   InParanoid; Q47129; -.
DR   OMA; FKSEAHF; -.
DR   PhylomeDB; Q47129; -.
DR   BioCyc; EcoCyc:G6706-MON; -.
DR   PRO; PR:Q47129; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:EcoCyc.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:EcoCyc.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:EcoCyc.
DR   InterPro; IPR035418; AraC-bd_2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR037923; HTH-like.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF14525; AraC_binding_2; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF51215; SSF51215; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   1: Evidence at protein level;
KW   Activator; Direct protein sequencing; DNA-binding; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..301
FT                   /note="Transcriptional activator FeaR"
FT                   /id="PRO_0000194513"
FT   DOMAIN          199..299
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        217..238
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        266..289
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   301 AA;  34620 MW;  BCB0B2CC67CEF652 CRC64;
     MNPAVDNEFQ QWLSQINQVC GNFTGRLLTE RYTGVLDTHF AKGLKLSTVT TSGVNLSRTW
     QEVKGSDDAW FYTVFQLSGQ AIMEQDERQV QIGAGDITLL DASRPCSLYW QESSKQISLL
     LPRTLLEQYF PHQKPICAER LDADLPMVQL SHRLLQESMN NPALSETESE AALQAMVCLL
     RPVLHQRESV QPRRERQFQK VVTLIDDNIR EEILRPEWIA GETGMSVRSL YRMFADKGLV
     VAQYIRNRRL DFCADAIRHA ADDEKLAGIG FHWGFSDQSH FSTVFKQRFG MTPGEYRRKF
     R