FECC_ECOLI
ID FECC_ECOLI Reviewed; 332 AA.
AC P15030; Q2M626;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 2.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Fe(3+) dicitrate transport system permease protein FecC;
DE AltName: Full=Iron(III) dicitrate transport system permease protein FecC;
GN Name=fecC; OrderedLocusNames=b4289, JW4249;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=2651410; DOI=10.1128/jb.171.5.2626-2633.1989;
RA Staudenmaier H., van Hove B., Yaraghi Z., Braun V.;
RT "Nucleotide sequences of the fecBCDE genes and locations of the proteins
RT suggest a periplasmic-binding-protein-dependent transport mechanism for
RT iron(III) dicitrate in Escherichia coli.";
RL J. Bacteriol. 171:2626-2633(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
RN [6]
RP INDUCTION BY HYDROXYUREA.
RC STRAIN=K12 / MC4100 / ATCC 35695 / DSM 6574;
RX PubMed=20005847; DOI=10.1016/j.molcel.2009.11.024;
RA Davies B.W., Kohanski M.A., Simmons L.A., Winkler J.A., Collins J.J.,
RA Walker G.C.;
RT "Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia
RT coli.";
RL Mol. Cell 36:845-860(2009).
CC -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC citrate-dependent Fe(3+). Probably responsible for the translocation of
CC the substrate across the membrane.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- INDUCTION: Induced 1.8-fold by hydroxyurea.
CC {ECO:0000269|PubMed:20005847}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. FecCD subfamily. {ECO:0000305}.
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DR EMBL; M26397; AAA23763.1; -; Genomic_DNA.
DR EMBL; U14003; AAA97185.1; -; Genomic_DNA.
DR EMBL; U00096; AAC77245.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE78280.1; -; Genomic_DNA.
DR PIR; S56514; QRECD1.
DR RefSeq; NP_418709.1; NC_000913.3.
DR RefSeq; WP_000125187.1; NZ_STEB01000013.1.
DR AlphaFoldDB; P15030; -.
DR SMR; P15030; -.
DR BioGRID; 4262741; 360.
DR ComplexPortal; CPX-4403; Ferric-citrate ABC transporter complex.
DR STRING; 511145.b4289; -.
DR TCDB; 3.A.1.14.1; the atp-binding cassette (abc) superfamily.
DR PaxDb; P15030; -.
DR PRIDE; P15030; -.
DR EnsemblBacteria; AAC77245; AAC77245; b4289.
DR EnsemblBacteria; BAE78280; BAE78280; BAE78280.
DR GeneID; 948826; -.
DR KEGG; ecj:JW4249; -.
DR KEGG; eco:b4289; -.
DR PATRIC; fig|1411691.4.peg.2410; -.
DR EchoBASE; EB0284; -.
DR eggNOG; COG0609; Bacteria.
DR HOGENOM; CLU_013016_1_0_6; -.
DR InParanoid; P15030; -.
DR OMA; GAPCFVW; -.
DR PhylomeDB; P15030; -.
DR BioCyc; EcoCyc:FECC-MON; -.
DR BioCyc; MetaCyc:FECC-MON; -.
DR PHI-base; PHI:8008; -.
DR PRO; PR:P15030; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IC:ComplexPortal.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IC:ComplexPortal.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0015603; F:iron chelate transmembrane transporter activity; IMP:EcoCyc.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0033212; P:iron import into cell; IC:ComplexPortal.
DR GO; GO:0055072; P:iron ion homeostasis; IC:ComplexPortal.
DR GO; GO:0033214; P:siderophore-dependent iron import into cell; IMP:EcoCyc.
DR Gene3D; 1.10.3470.10; -; 1.
DR InterPro; IPR037294; ABC_BtuC-like.
DR InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR PANTHER; PTHR30472; PTHR30472; 1.
DR Pfam; PF01032; FecCD; 1.
DR SUPFAM; SSF81345; SSF81345; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Ion transport; Iron; Iron transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..332
FT /note="Fe(3+) dicitrate transport system permease protein
FT FecC"
FT /id="PRO_0000060020"
FT TOPO_DOM 1..7
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..64
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 86..118
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..152
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..199
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..244
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..280
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..307
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 329..332
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 103..123
FT /note="LAMALTSALSPTPIAGYSLSF -> WLWRYQRAESDADCRLFSVV (in
FT Ref. 1; AAA23763)"
FT /evidence="ECO:0000305"
FT CONFLICT 178
FT /note="A -> AS (in Ref. 1; AAA23763)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 332 AA; 34893 MW; 1BCE861FEE5E16DB CRC64;
MTAIKHPVLL WGLPVAALII IFWLSLFCYS AIPVSGADAT RALLPGHTPT LPEALVQNLR
LPRSLVAVLI GASLALAGTL LQTLTHNPMA SPSLLGINSG AALAMALTSA LSPTPIAGYS
LSFIAACGGG VSWLLVMTAG GGFRHTHDRN KLILAGIALS AFCMGLTRIT LLLAEDHAYG
IFYWLAGGVS HARWQDVWQL LPVVVTAVPV VLLLANQLNL LNLSDSTAHT LGVNLTRLRL
VINMLVLLLV GACVSVAGPV AFIGLLVPHL ARFWAGFDQR NVLPVSMLLG ATLMLLADVL
ARALAFPGDL PAGAVLALIG SPCFVWLVRR RG
