FECD_ECOLI
ID FECD_ECOLI Reviewed; 318 AA.
AC P15029; Q2M627;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Fe(3+) dicitrate transport system permease protein FecD;
DE AltName: Full=Iron(III) dicitrate transport system permease protein FecD;
GN Name=fecD; OrderedLocusNames=b4288, JW4248;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=2651410; DOI=10.1128/jb.171.5.2626-2633.1989;
RA Staudenmaier H., van Hove B., Yaraghi Z., Braun V.;
RT "Nucleotide sequences of the fecBCDE genes and locations of the proteins
RT suggest a periplasmic-binding-protein-dependent transport mechanism for
RT iron(III) dicitrate in Escherichia coli.";
RL J. Bacteriol. 171:2626-2633(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
RN [6]
RP INDUCTION BY HYDROXYUREA.
RC STRAIN=K12 / MC4100 / ATCC 35695 / DSM 6574;
RX PubMed=20005847; DOI=10.1016/j.molcel.2009.11.024;
RA Davies B.W., Kohanski M.A., Simmons L.A., Winkler J.A., Collins J.J.,
RA Walker G.C.;
RT "Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia
RT coli.";
RL Mol. Cell 36:845-860(2009).
CC -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC citrate-dependent Fe(3+). Probably responsible for the translocation of
CC the substrate across the membrane.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- INDUCTION: Induced 1.3-fold by hydroxyurea.
CC {ECO:0000269|PubMed:20005847}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. FecCD subfamily. {ECO:0000305}.
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DR EMBL; M26397; AAA23764.1; -; Genomic_DNA.
DR EMBL; U14003; AAA97184.1; -; Genomic_DNA.
DR EMBL; U00096; AAC77244.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE78279.1; -; Genomic_DNA.
DR PIR; S56513; QRECD2.
DR RefSeq; NP_418708.1; NC_000913.3.
DR RefSeq; WP_000684852.1; NZ_LN832404.1.
DR AlphaFoldDB; P15029; -.
DR SMR; P15029; -.
DR BioGRID; 4262740; 325.
DR ComplexPortal; CPX-4403; Ferric-citrate ABC transporter complex.
DR STRING; 511145.b4288; -.
DR TCDB; 3.A.1.14.1; the atp-binding cassette (abc) superfamily.
DR PaxDb; P15029; -.
DR PRIDE; P15029; -.
DR EnsemblBacteria; AAC77244; AAC77244; b4288.
DR EnsemblBacteria; BAE78279; BAE78279; BAE78279.
DR GeneID; 946816; -.
DR KEGG; ecj:JW4248; -.
DR KEGG; eco:b4288; -.
DR PATRIC; fig|1411691.4.peg.2411; -.
DR EchoBASE; EB0285; -.
DR eggNOG; COG0609; Bacteria.
DR HOGENOM; CLU_013016_1_1_6; -.
DR InParanoid; P15029; -.
DR OMA; SFRMPRI; -.
DR PhylomeDB; P15029; -.
DR BioCyc; EcoCyc:FECD-MON; -.
DR BioCyc; MetaCyc:FECD-MON; -.
DR PHI-base; PHI:8009; -.
DR PRO; PR:P15029; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IC:ComplexPortal.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IC:ComplexPortal.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0015603; F:iron chelate transmembrane transporter activity; IMP:EcoCyc.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0033212; P:iron import into cell; IC:ComplexPortal.
DR GO; GO:0055072; P:iron ion homeostasis; IC:ComplexPortal.
DR GO; GO:0033214; P:siderophore-dependent iron import into cell; IMP:EcoCyc.
DR Gene3D; 1.10.3470.10; -; 1.
DR InterPro; IPR037294; ABC_BtuC-like.
DR InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR PANTHER; PTHR30472; PTHR30472; 1.
DR Pfam; PF01032; FecCD; 1.
DR SUPFAM; SSF81345; SSF81345; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Ion transport; Iron; Iron transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..318
FT /note="Fe(3+) dicitrate transport system permease protein
FT FecD"
FT /id="PRO_0000060021"
FT TOPO_DOM 1..2
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 24..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..84
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..137
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..179
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..225
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..269
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..294
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 41
FT /note="H -> R (in Ref. 1; AAA23764)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 318 AA; 34131 MW; 2C86FAD547904693 CRC64;
MKIALVIFIT LALAGCALLS LHMGVIPVPW RALLTDWQAG HEHYYVLMEY RLPRLLLALF
VGAALAVAGV LIQGIVRNPL ASPDILGVNH AASLASVGAL LLMPSLPVMV LPLLAFAGGM
AGLILLKMLA KTHQPMKLAL TGVALSACWA SLTDYLMLSR PQDVNNALLW LTGSLWGRDW
SFVKIAIPLM ILFLPLSLSF CRDLDLLALG DARATTLGVS VPHTRFWALL LAVAMTSTGV
AACGPISFIG LVVPHMMRSI TGGRHRRLLP VSALTGALLL VVADLLARII HPPLELPVGV
LTAIIGAPWF VWLLVRMR
