FECR_ECOLI
ID FECR_ECOLI Reviewed; 317 AA.
AC P23485; Q2M623;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1991, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Protein FecR;
GN Name=fecR; OrderedLocusNames=b4292, JW4252;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=2254251; DOI=10.1128/jb.172.12.6749-6758.1990;
RA van Hove B., Staudenmaier H., Braun V.;
RT "Novel two-component transmembrane transcription control: regulation of
RT iron dicitrate transport in Escherichia coli K-12.";
RL J. Bacteriol. 172:6749-6758(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP INDUCTION BY HYDROXYUREA.
RC STRAIN=K12 / MC4100 / ATCC 35695 / DSM 6574;
RX PubMed=20005847; DOI=10.1016/j.molcel.2009.11.024;
RA Davies B.W., Kohanski M.A., Simmons L.A., Winkler J.A., Collins J.J.,
RA Walker G.C.;
RT "Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia
RT coli.";
RL Mol. Cell 36:845-860(2009).
CC -!- FUNCTION: Regulation of iron dicitrate transport. In the absence of
CC citrate FecR inactivates fecI. FecR is probably a sensor that
CC recognizes iron dicitrate in the periplasm.
CC -!- SUBCELLULAR LOCATION: Periplasm.
CC -!- INDUCTION: Induced by hydroxyurea. {ECO:0000269|PubMed:20005847}.
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DR EMBL; M63115; AAA23767.1; -; Genomic_DNA.
DR EMBL; U14003; AAA97188.1; -; Genomic_DNA.
DR EMBL; U00096; AAC77248.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE78283.1; -; Genomic_DNA.
DR PIR; B37804; B37804.
DR RefSeq; NP_418712.1; NC_000913.3.
DR RefSeq; WP_001068910.1; NZ_STEB01000013.1.
DR AlphaFoldDB; P23485; -.
DR SMR; P23485; -.
DR DIP; DIP-9589N; -.
DR IntAct; P23485; 3.
DR STRING; 511145.b4292; -.
DR PaxDb; P23485; -.
DR PRIDE; P23485; -.
DR EnsemblBacteria; AAC77248; AAC77248; b4292.
DR EnsemblBacteria; BAE78283; BAE78283; BAE78283.
DR GeneID; 58462729; -.
DR GeneID; 949104; -.
DR KEGG; ecj:JW4252; -.
DR KEGG; eco:b4292; -.
DR PATRIC; fig|1411691.4.peg.2407; -.
DR EchoBASE; EB0288; -.
DR eggNOG; COG3712; Bacteria.
DR HOGENOM; CLU_050192_0_0_6; -.
DR InParanoid; P23485; -.
DR OMA; IMVTSGH; -.
DR PhylomeDB; P23485; -.
DR BioCyc; EcoCyc:EG10292-MON; -.
DR PHI-base; PHI:8005; -.
DR PRO; PR:P23485; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:EcoCyc.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0016989; F:sigma factor antagonist activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:EcoCyc.
DR GO; GO:0006879; P:cellular iron ion homeostasis; IMP:EcoCyc.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:2000142; P:regulation of DNA-templated transcription, initiation; IMP:EcoCyc.
DR GO; GO:0023019; P:signal transduction involved in regulation of gene expression; TAS:EcoCyc.
DR InterPro; IPR006860; FecR.
DR InterPro; IPR032623; FecR_N.
DR InterPro; IPR012373; Ferrdict_sens_TM.
DR PANTHER; PTHR30273; PTHR30273; 1.
DR Pfam; PF16220; DUF4880; 1.
DR Pfam; PF04773; FecR; 1.
DR PIRSF; PIRSF018266; FecR; 1.
PE 2: Evidence at transcript level;
KW Ion transport; Iron; Iron transport; Periplasm; Reference proteome;
KW Sensory transduction; Transport.
FT CHAIN 1..317
FT /note="Protein FecR"
FT /id="PRO_0000087218"
SQ SEQUENCE 317 AA; 35532 MW; 798EC615815AF9D7 CRC64;
MNPLLTDSRR QALRSASHWY AVLSGERVSP QQEARWQQWY EQDQDNQWAW QQVENLRNQL
GGVPGDVASR ALHDTRLTRR HVMKGLLLLL GAGGGWQLWQ SETGEGLRAD YRTAKGTVSR
QQLEDGSLLT LNTQSAADVR FDAHQRTVRL WYGEIAITTA KDALQRPFRV LTRQGQLTAL
GTEFTVRQQD NFTQLDVQQH AVEVLLASAP AQKRIVNAGE SLQFSASEFG AVKPLDDEST
SWTKDILSFS DKPLGEVIAT LTRYRNGVLR CDPAVAGLRL SGTFPLKNTD AILNVIAQTL
PVKIQSITRY WINISPL