FEH1_CAEEL
ID FEH1_CAEEL Reviewed; 665 AA.
AC Q9BKZ9; H2L0Q7; H2L0Q8; Q8WQE2;
DT 11-NOV-2015, integrated into UniProtKB/Swiss-Prot.
DT 11-NOV-2015, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Protein Fe65 homolog {ECO:0000312|WormBase:Y54F10AM.2a};
GN Name=feh-1 {ECO:0000312|WormBase:Y54F10AM.2a};
GN ORFNames=Y54F10AM.2 {ECO:0000312|WormBase:Y54F10AM.2a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000312|EMBL:CAC87812.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 89-665 (ISOFORM A), FUNCTION, INTERACTION
RP WITH APL-1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP PHOSPHORYLATION, AND DISRUPTION PHENOTYPE.
RX PubMed=11896189; DOI=10.1242/jcs.115.7.1411;
RA Zambrano N., Bimonte M., Arbucci S., Gianni D., Russo T., Bazzicalupo P.;
RT "feh-1 and apl-1, the Caenorhabditis elegans orthologues of mammalian Fe65
RT and beta-amyloid precursor protein genes, are involved in the same pathway
RT that controls nematode pharyngeal pumping.";
RL J. Cell Sci. 115:1411-1422(2002).
RN [3] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=15355315; DOI=10.1111/j.1460-9568.2004.03611.x;
RA Bimonte M., Gianni D., Allegra D., Russo T., Zambrano N.;
RT "Mutation of the feh-1 gene, the Caenorhabditis elegans orthologue of
RT mammalian Fe65, decreases the expression of two acetylcholinesterase
RT genes.";
RL Eur. J. Neurosci. 20:1483-1488(2004).
CC -!- FUNCTION: Modulates pharyngeal pumping activity, at least in part by
CC regulating expression of the acetylcholinesterase genes ace-1 and ace-2
CC (PubMed:11896189, PubMed:15355315). {ECO:0000269|PubMed:11896189,
CC ECO:0000269|PubMed:15355315}.
CC -!- SUBUNIT: Interacts (via PID 2 domain) with apl-1 (via cytoplasmic
CC domain). {ECO:0000269|PubMed:11896189}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11896189}.
CC Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11896189}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=a {ECO:0000312|WormBase:Y54F10AM.2a};
CC IsoId=Q9BKZ9-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:Y54F10AM.2b};
CC IsoId=Q9BKZ9-2; Sequence=VSP_057961;
CC Name=c {ECO:0000312|WormBase:Y54F10AM.2c};
CC IsoId=Q9BKZ9-3; Sequence=VSP_057960;
CC -!- TISSUE SPECIFICITY: Expressed in the pharynx (including pharyngeal
CC muscle and nerve cells), ventral nerve cord and tail neurons.
CC {ECO:0000269|PubMed:11896189}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the pharynx from three-fold stage
CC embryos to adulthood. {ECO:0000269|PubMed:11896189}.
CC -!- PTM: Phosphorylated. {ECO:0000269|PubMed:11896189}.
CC -!- DISRUPTION PHENOTYPE: Embryonic lethality or larval arrest
CC (PubMed:11896189, PubMed:15355315). Heterozygous animals are viable and
CC display increased pharyngeal pumping rates associated with reduced
CC acetylcholinesterase activity (PubMed:11896189, PubMed:15355315).
CC {ECO:0000269|PubMed:11896189, ECO:0000269|PubMed:15355315}.
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DR EMBL; BX284603; CCD73819.2; -; Genomic_DNA.
DR EMBL; BX284603; CCD73820.1; -; Genomic_DNA.
DR EMBL; BX284603; CCD73821.1; -; Genomic_DNA.
DR EMBL; AJ345015; CAC87812.1; -; mRNA.
DR RefSeq; NP_001022906.1; NM_001027735.3. [Q9BKZ9-2]
DR RefSeq; NP_001022907.1; NM_001027736.4.
DR RefSeq; NP_497578.4; NM_065177.4. [Q9BKZ9-1]
DR AlphaFoldDB; Q9BKZ9; -.
DR SMR; Q9BKZ9; -.
DR DIP; DIP-25952N; -.
DR IntAct; Q9BKZ9; 2.
DR STRING; 6239.Y54F10AM.2a; -.
DR EPD; Q9BKZ9; -.
DR PaxDb; Q9BKZ9; -.
DR PeptideAtlas; Q9BKZ9; -.
DR EnsemblMetazoa; Y54F10AM.2a.1; Y54F10AM.2a.1; WBGene00001410. [Q9BKZ9-1]
DR EnsemblMetazoa; Y54F10AM.2b.1; Y54F10AM.2b.1; WBGene00001410. [Q9BKZ9-2]
DR EnsemblMetazoa; Y54F10AM.2c.1; Y54F10AM.2c.1; WBGene00001410. [Q9BKZ9-3]
DR EnsemblMetazoa; Y54F10AM.2c.2; Y54F10AM.2c.2; WBGene00001410. [Q9BKZ9-3]
DR GeneID; 175373; -.
DR KEGG; cel:CELE_Y54F10AM.2; -.
DR UCSC; Y54F10AM.2c.2; c. elegans.
DR CTD; 175373; -.
DR WormBase; Y54F10AM.2a; CE50322; WBGene00001410; feh-1. [Q9BKZ9-1]
DR WormBase; Y54F10AM.2b; CE32985; WBGene00001410; feh-1. [Q9BKZ9-2]
DR WormBase; Y54F10AM.2c; CE38648; WBGene00001410; feh-1. [Q9BKZ9-3]
DR eggNOG; ENOG502QT08; Eukaryota.
DR GeneTree; ENSGT00390000000002; -.
DR InParanoid; Q9BKZ9; -.
DR OMA; NMAVDYS; -.
DR OrthoDB; 437627at2759; -.
DR Reactome; R-CEL-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
DR PRO; PR:Q9BKZ9; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00001410; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR ExpressionAtlas; Q9BKZ9; baseline and differential.
DR GO; GO:0005884; C:actin filament; IDA:WormBase.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001540; F:amyloid-beta binding; IDA:WormBase.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR GO; GO:0007631; P:feeding behavior; IMP:WormBase.
DR GO; GO:0002119; P:nematode larval development; IMP:WormBase.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.30.29.30; -; 2.
DR InterPro; IPR039576; APBB1/2/3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR14058; PTHR14058; 1.
DR Pfam; PF00640; PID; 2.
DR SMART; SM00462; PTB; 2.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF51045; SSF51045; 1.
DR PROSITE; PS01179; PID; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Cytoskeleton; Reference proteome; Repeat;
KW Transcription; Transcription regulation.
FT CHAIN 1..665
FT /note="Protein Fe65 homolog"
FT /evidence="ECO:0000305"
FT /id="PRO_0000434596"
FT DOMAIN 233..266
FT /note="WW"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT DOMAIN 330..456
FT /note="PID 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00148"
FT DOMAIN 499..615
FT /note="PID 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00148"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..111
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_057960"
FT VAR_SEQ 639..665
FT /note="KGWTETFRDAFGSVTSRMVPSRSAQRL -> MD (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_057961"
SQ SEQUENCE 665 AA; 76322 MW; A26E8260C2852D3F CRC64;
MREGTPRVRI EVNKGSNRPS QFVSESEEQR LQRVQSRDSD TATMNFVTDD RMMEEHDEYS
AFKEAYEEEE SREYVIENGV KRLVNQHYDS RGYSSAGRGQ KGRREEERRR NMAVDYSSQD
FRQSLAAIDQ ASRDGAISRG EDGVRVRQIG DTTIMTEHRD PYSFYWQLDQ ARREAESPPR
RPPPTDYVID EEEEVLETVY SPEADDVMFE NQYRRPVRHP LPPPPPIMEE EPKDLPPGWE
KHEDPQGYSY YWHVDSGTIQ RQPPPPVNRE TQADAPPPQI IQLPPQQPVI EEHAFKQTTT
KRRIEQDEMS EREIEDVAMI ENGDTYHKPV RFAVRSLGWT DISEDELTAE KSSRAVNRAI
VDLTTRSDID SIPKWGDGRE LIMELDDNEL ALLDPDSMNV IHSERIQAIR VWGVGRDNGR
DFAYVSRDRG TRRFMCHVFR CDTSAKTIAN TLRDICKRLM LHRRPSSLHA IESGEKRIVR
SEGLTAPIDE PRKVIRCHFL GVTQVPKATG IEILNEAVDR LVSQVRSERW ILADVSIAPS
TIAIVEVNGQ QIAECRVRYL SFLGIGRDVK HCAFIMQTSS ESFMCYVFHV EPNAAAMAKM
VEAACKLRYQ KVLDAHSSSR HHSGMSIHGQ HPPSTYHGKG WTETFRDAFG SVTSRMVPSR
SAQRL
