FEL1A_FELCA
ID FEL1A_FELCA Reviewed; 92 AA.
AC P30438; P30439;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=Major allergen I polypeptide chain 1;
DE AltName: Full=AG4;
DE AltName: Full=Allergen Cat-1;
DE AltName: Full=Allergen Fel d I-A;
DE Short=Allergen FdI;
DE Short=Allergen Fel dI;
DE AltName: Allergen=Fel d 1-A;
DE Flags: Precursor;
GN Name=CH1;
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 23-92 (ISOFORMS 1 AND
RP 2).
RC TISSUE=Salivary gland;
RX PubMed=1946388; DOI=10.1073/pnas.88.21.9690;
RA Morgenstern J.P., Griffith I.J., Brauer A.W., Rogers B.L., Bond J.F.,
RA Chapman M.D., Kuo M.-C.;
RT "Amino acid sequence of Fel dI, the major allergen of the domestic cat:
RT protein sequence analysis and cDNA cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:9690-9694(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
RC TISSUE=Liver;
RX PubMed=1572548; DOI=10.1016/0378-1119(92)90405-e;
RA Griffith I.J., Craig S., Pollock J., Yu X.-B., Morgenstern J.P.,
RA Rogers B.L.;
RT "Expression and genomic structure of the genes encoding FdI, the major
RT allergen from the domestic cat.";
RL Gene 113:263-268(1992).
RN [3]
RP PROTEIN SEQUENCE OF 23-62, AND CHARACTERIZATION.
RX PubMed=1712068; DOI=10.1016/0161-5890(91)90141-6;
RA Duffort O.A., Carreira J., Nitti G., Polo F., Lombardero M.;
RT "Studies on the biochemical structure of the major cat allergen Felis
RT domesticus I.";
RL Mol. Immunol. 28:301-309(1991).
RN [4]
RP CHARACTERIZATION.
RX PubMed=6747135; DOI=10.1016/0091-6749(84)90278-1;
RA Leitermann K., Ohman J.L. Jr.;
RT "Cat allergen 1: biochemical, antigenic, and allergenic properties.";
RL J. Allergy Clin. Immunol. 74:147-153(1984).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
RX PubMed=12851385; DOI=10.1074/jbc.m304740200;
RA Kaiser L., Gronlund H., Sandalova T., Ljunggren H.G., van Hage-Hamsten M.,
RA Achour A., Schneider G.;
RT "The crystal structure of the major cat allergen Fel d 1, a member of the
RT secretoglobin family.";
RL J. Biol. Chem. 278:37730-37735(2003).
CC -!- SUBUNIT: Heterotetramer composed of two non-covalently linked
CC disulfide-linked heterodimer of chains 1 and 2.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=Leader A, Major;
CC IsoId=P30438-1; Sequence=Displayed;
CC Name=2; Synonyms=Leader B, Minor;
CC IsoId=P30438-2; Sequence=VSP_015665;
CC -!- TISSUE SPECIFICITY: Saliva and sebaceous glands.
CC -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE. Major
CC allergen produced by the domestic cat. Implicated as an asthma-inducing
CC agent in human. This protein is sticky and easily adheres to walls,
CC carpet, clothing, furniture and bedding.
CC -!- SIMILARITY: Belongs to the secretoglobin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA44343.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAA44344.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M74952; AAC37318.1; -; mRNA.
DR EMBL; M74953; AAC41617.1; -; mRNA.
DR EMBL; X62477; CAA44344.1; ALT_INIT; Genomic_DNA.
DR EMBL; X62477; CAA44343.1; ALT_INIT; Genomic_DNA.
DR PIR; A56413; A56413.
DR PIR; JC1136; JC1136.
DR RefSeq; NP_001041618.1; NM_001048153.1.
DR PDB; 1PUO; X-ray; 1.85 A; A/B=23-92.
DR PDB; 1ZKR; X-ray; 1.64 A; A/B=23-92.
DR PDB; 2EJN; X-ray; 1.64 A; A/B=23-92.
DR PDB; 5VYF; X-ray; 2.90 A; C/F=23-92.
DR PDBsum; 1PUO; -.
DR PDBsum; 1ZKR; -.
DR PDBsum; 2EJN; -.
DR PDBsum; 5VYF; -.
DR AlphaFoldDB; P30438; -.
DR SMR; P30438; -.
DR STRING; 9685.ENSFCAP00000022316; -.
DR Allergome; 3278; Fel d 1.0101.
DR Allergome; 345; Fel d 1.
DR ABCD; P30438; 4 sequenced antibodies.
DR GeneID; 677877; -.
DR eggNOG; ENOG502RTYP; Eukaryota.
DR InParanoid; P30438; -.
DR EvolutionaryTrace; P30438; -.
DR Proteomes; UP000011712; Unplaced.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0005496; F:steroid binding; IBA:GO_Central.
DR CDD; cd00633; Secretoglobin; 1.
DR InterPro; IPR006178; CH1-like.
DR InterPro; IPR016126; Secretoglobin.
DR InterPro; IPR035960; Secretoglobin_sf.
DR PANTHER; PTHR21226; PTHR21226; 1.
DR Pfam; PF01099; Uteroglobin; 1.
DR PRINTS; PR00827; FELALLERGEN.
DR SUPFAM; SSF48201; SSF48201; 1.
DR PROSITE; PS51311; SCGB; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Allergen; Alternative splicing; Direct protein sequencing;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000269|PubMed:1712068"
FT CHAIN 23..92
FT /note="Major allergen I polypeptide chain 1"
FT /id="PRO_0000036370"
FT DISULFID 25
FT /note="Interchain (with C-90 in chain 2)"
FT DISULFID 66
FT /note="Interchain (with C-65 in chain 2)"
FT DISULFID 92
FT /note="Interchain (with C-24 in chain 2)"
FT VAR_SEQ 1..21
FT /note="MKGACVLVLLWAALLLISGGN -> MLDAALPPCPTVAATAD (in
FT isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_015665"
FT VARIANT 51
FT /note="K -> N"
FT CONFLICT 5
FT /note="C -> R (in Ref. 1; AAC37318)"
FT /evidence="ECO:0000305"
FT CONFLICT 18
FT /note="S -> W (in Ref. 1; AAC37318)"
FT /evidence="ECO:0000305"
FT CONFLICT 82
FT /note="V -> L (in Ref. 1; AAC41617/AAC37318)"
FT /evidence="ECO:0000305"
FT HELIX 26..37
FT /evidence="ECO:0007829|PDB:1ZKR"
FT HELIX 40..50
FT /evidence="ECO:0007829|PDB:1ZKR"
FT HELIX 54..70
FT /evidence="ECO:0007829|PDB:1ZKR"
FT HELIX 73..87
FT /evidence="ECO:0007829|PDB:1ZKR"
SQ SEQUENCE 92 AA; 10086 MW; 083145F55EE8AAB3 CRC64;
MKGACVLVLL WAALLLISGG NCEICPAVKR DVDLFLTGTP DEYVEQVAQY KALPVVLENA
RILKNCVDAK MTEEDKENAL SVLDKIYTSP LC
