FEM1B_CHICK
ID FEM1B_CHICK Reviewed; 627 AA.
AC Q5ZM55;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Protein fem-1 homolog B {ECO:0000305};
DE Short=FEM1b {ECO:0000250|UniProtKB:Q9UK73};
DE AltName: Full=FEM1-beta;
GN Name=FEM1B {ECO:0000250|UniProtKB:Q9UK73};
GN ORFNames=RCJMB04_3b14 {ECO:0000303|PubMed:15642098};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3
CC ubiquitin-protein ligase complex of the DesCEND (destruction via C-end
CC degrons) pathway, which recognizes a C-degron located at the extreme C
CC terminus of target proteins, leading to their ubiquitination and
CC degradation. The C-degron recognized by the DesCEND pathway is usually
CC a motif of less than ten residues and can be present in full-length
CC proteins, truncated proteins or proteolytically cleaved forms. The
CC CRL2(FEM1B) complex specifically recognizes proteins ending with -Gly-
CC Leu-Asp-Arg, leading to their ubiquitination and degradation.
CC {ECO:0000250|UniProtKB:Q9UK73}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000250|UniProtKB:Q9UK73}.
CC -!- SUBUNIT: Component of a CRL2 E3 ubiquitin-protein ligase complex, also
CC named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex.
CC {ECO:0000250|UniProtKB:Q9UK73}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UK73}. Nucleus
CC {ECO:0000250|UniProtKB:Q9UK73}.
CC -!- SIMILARITY: Belongs to the fem-1 family. {ECO:0000305}.
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DR EMBL; AJ719529; CAG31188.1; -; mRNA.
DR RefSeq; NP_001025724.1; NM_001030553.1.
DR AlphaFoldDB; Q5ZM55; -.
DR SMR; Q5ZM55; -.
DR STRING; 9031.ENSGALP00000042401; -.
DR GeneID; 415559; -.
DR KEGG; gga:415559; -.
DR CTD; 10116; -.
DR VEuPathDB; HostDB:geneid_415559; -.
DR eggNOG; KOG0508; Eukaryota.
DR InParanoid; Q5ZM55; -.
DR OrthoDB; 252380at2759; -.
DR PhylomeDB; Q5ZM55; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q5ZM55; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; ISS:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:2000001; P:regulation of DNA damage checkpoint; ISS:UniProtKB.
DR GO; GO:0140627; P:ubiquitin-dependent protein catabolic process via the C-end degron rule pathway; ISS:UniProtKB.
DR Gene3D; 1.25.40.20; -; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 8.
DR SUPFAM; SSF48403; SSF48403; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 6.
PE 2: Evidence at transcript level;
KW ANK repeat; Apoptosis; Cytoplasm; Nucleus; Reference proteome; Repeat;
KW TPR repeat; Ubl conjugation pathway.
FT CHAIN 1..627
FT /note="Protein fem-1 homolog B"
FT /id="PRO_0000324533"
FT REPEAT 45..74
FT /note="ANK 1"
FT REPEAT 87..116
FT /note="ANK 2"
FT REPEAT 120..149
FT /note="ANK 3"
FT REPEAT 153..182
FT /note="ANK 4"
FT REPEAT 186..215
FT /note="ANK 5"
FT REPEAT 218..248
FT /note="ANK 6"
FT REPEAT 344..377
FT /note="TPR"
FT REPEAT 483..527
FT /note="ANK 7"
FT REPEAT 531..568
FT /note="ANK 8"
SQ SEQUENCE 627 AA; 70394 MW; 8B31106D0DAE0708 CRC64;
MEGLAGYVYK AASEGRVLTL AALLLNRSES DIKYLLGYVS QHGGQRSTPL IIAARNGHTK
VVRLLLEHYR VQTQQTGTVR FDGFVIDGAT ALWCAAGAGH FEVVKLLVSH GANVNHTTVT
NSTPLRAACF DGRLDIVKYL VENNANISIA NKYDNTCLMI AAYKGHTDVV RYLLEQHADP
NAKAHCGATA LHFAAEAGHL EIVRELVKWK AAMMVNGHGM TPLKVAAESC KADVVELLLA
HAGCNRRSRI EALELLGASF ANDRENYDIM KTYHYLYLAM LERYRDSENI IEKEVLPPIE
AYGNRTECRT PQELESIRQD RDALHMEGLI VRERILGSDN IDVSHPIIYR GAVYADNMEF
EQCIKLWLHA LHLRQKGNRN THKDLLRFAQ VFSQMIHLNE PVKAKDIESV LRCSVLEIEQ
GMSRIKATQD DDIHTAVDNY ECNIFTFLYL VCISTKTQCS EEDQSRINKQ IYNLIHLDPR
TRDGSTLLHH AVNSSTPVDD FHTNDVCSFP NALVTKLLLD CGADVNAVDN EGNSPLHLIV
QYHRPISDFL TLHSIIISLV EAGAHTDMTN KQKKTPLDKS TTGVSEILLK TQMKLSLKCL
AARAVRIYNI SYQNQIPRTL EEFVKFH
