AIR2_CAEBR
ID AIR2_CAEBR Reviewed; 302 AA.
AC Q61XD3; A8WW15;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Aurora/IPL1-related protein kinase 2;
DE EC=2.7.11.1;
DE AltName: Full=Serine/threonine-protein kinase aurora-B;
GN Name=air-2; ORFNames=CBG04030;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Serine/threonine-protein kinase which mediates both meiotic
CC and mitotic chromosome segregation. Required for histone H3 'Ser-10'
CC phosphorylation. Phosphorylates tlk-1 and zen-4 (By similarity).
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- SUBUNIT: Interacts with zen-4 and icp-1. Part of a complex containing
CC at least air-2; icp-1; csc-1 and bir-1. Interacts with tlk-1 and bmk-1
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Chromosome
CC {ECO:0000250}. Midbody {ECO:0000250}. Note=Meiotic and mitotic
CC chromosomes. During each division, relocates to the midbody
CC microtubules (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; HE600906; CAP24824.3; -; Genomic_DNA.
DR RefSeq; XP_002639437.1; XM_002639391.1.
DR AlphaFoldDB; Q61XD3; -.
DR SMR; Q61XD3; -.
DR STRING; 6238.CBG04030; -.
DR PRIDE; Q61XD3; -.
DR EnsemblMetazoa; CBG04030.1; CBG04030.1; WBGene00026778.
DR GeneID; 8581430; -.
DR KEGG; cbr:CBG_04030; -.
DR CTD; 8581430; -.
DR WormBase; CBG04030; CBP01028; WBGene00026778; Cbr-air-2.
DR eggNOG; KOG0580; Eukaryota.
DR HOGENOM; CLU_000288_63_0_1; -.
DR InParanoid; Q61XD3; -.
DR OMA; PYGRQTT; -.
DR OrthoDB; 954262at2759; -.
DR Proteomes; UP000008549; Chromosome I.
DR GO; GO:0032133; C:chromosome passenger complex; IBA:GO_Central.
DR GO; GO:0000794; C:condensed nuclear chromosome; IEA:EnsemblMetazoa.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR GO; GO:0051233; C:spindle midzone; IBA:GO_Central.
DR GO; GO:0031616; C:spindle pole centrosome; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0051117; F:ATPase binding; IEA:EnsemblMetazoa.
DR GO; GO:0035174; F:histone serine kinase activity; IBA:GO_Central.
DR GO; GO:0019894; F:kinesin binding; IEA:EnsemblMetazoa.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:EnsemblMetazoa.
DR GO; GO:0045184; P:establishment of protein localization; IEA:EnsemblMetazoa.
DR GO; GO:0051257; P:meiotic spindle midzone assembly; IEA:EnsemblMetazoa.
DR GO; GO:0051256; P:mitotic spindle midzone assembly; IEA:EnsemblMetazoa.
DR GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR GO; GO:0018107; P:peptidyl-threonine phosphorylation; IEA:EnsemblMetazoa.
DR GO; GO:0046777; P:protein autophosphorylation; IEA:EnsemblMetazoa.
DR GO; GO:0031991; P:regulation of actomyosin contractile ring contraction; IEA:EnsemblMetazoa.
DR GO; GO:0032465; P:regulation of cytokinesis; IBA:GO_Central.
DR InterPro; IPR030616; Aur.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24350; PTHR24350; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell cycle; Cell division; Chromatin regulator; Chromosome;
KW Chromosome partition; Cytoplasm; Cytoskeleton; Developmental protein;
KW Kinase; Meiosis; Mitosis; Nucleotide-binding; Reference proteome;
KW Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..302
FT /note="Aurora/IPL1-related protein kinase 2"
FT /id="PRO_0000268639"
FT DOMAIN 27..277
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 150
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 33..41
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 56
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 302 AA; 34465 MW; 46AFF54C88C21685 CRC64;
MENKPQILQT KSKNTPNKGG KLSINDFEIG RPLGKGKFGS VYLARTKTGH FHCAIKVLFK
SQLISGGVEH QLEREIEIQS HLQHPNIIRL YNYFWDAKKI YLILEYAPGG EMYKQLTTQK
RFTEAMAGKY MYEIADALSY CHRKNVIHRD IKPENLLIGA QGELKIGDFG WSVHAPSNKR
QTMCGTMDYL PPEMVNGNSH SDAVDLWAIG VLCYEFLVGK PPFEHENQAD TYSAIKAGRF
TYPDFVKKGA RDLIGKLLVV DPRRRCSLQE VKDHYWVTSM LDSCRRAAEK QKAERAASLR
DH
