AIRSR_SALTY
ID AIRSR_SALTY Reviewed; 240 AA.
AC Q8ZKR0;
DT 07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=HTH-type transcriptional repressor STM4068 {ECO:0000305};
GN OrderedLocusNames=STM4068 {ECO:0000312|EMBL:AAL22908.1};
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=LT2;
RX PubMed=12486071; DOI=10.1128/jb.185.1.332-339.2003;
RA Dougherty M., Downs D.M.;
RT "The stm4066 gene product of Salmonella enterica serovar Typhimurium has
RT aminoimidazole riboside (AIRs) kinase activity and allows AIRs to satisfy
RT the thiamine requirement of pur mutant strains.";
RL J. Bacteriol. 185:332-339(2003).
CC -!- FUNCTION: Represses the expression of the STM4065-STM4067 operon.
CC {ECO:0000269|PubMed:12486071}.
CC -!- DISRUPTION PHENOTYPE: Null mutant gains the ability to efficiently use
CC exogenous aminoimidazole riboside (AIRs) as a source of thiamine.
CC {ECO:0000269|PubMed:12486071}.
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DR EMBL; AE006468; AAL22908.1; -; Genomic_DNA.
DR RefSeq; NP_462949.1; NC_003197.2.
DR RefSeq; WP_001519915.1; NC_003197.2.
DR AlphaFoldDB; Q8ZKR0; -.
DR SMR; Q8ZKR0; -.
DR STRING; 99287.STM4068; -.
DR PaxDb; Q8ZKR0; -.
DR EnsemblBacteria; AAL22908; AAL22908; STM4068.
DR GeneID; 1255595; -.
DR KEGG; stm:STM4068; -.
DR PATRIC; fig|99287.12.peg.4288; -.
DR HOGENOM; CLU_063236_4_2_6; -.
DR OMA; FLPEHYT; -.
DR PhylomeDB; Q8ZKR0; -.
DR BioCyc; SENT99287:STM4068-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.40.1410.10; -; 1.
DR InterPro; IPR028978; Chorismate_lyase_/UTRA_dom_sf.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR011663; UTRA.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00392; GntR; 1.
DR Pfam; PF07702; UTRA; 1.
DR SMART; SM00345; HTH_GNTR; 1.
DR SMART; SM00866; UTRA; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF64288; SSF64288; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 4: Predicted;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..240
FT /note="HTH-type transcriptional repressor STM4068"
FT /id="PRO_0000452104"
FT DOMAIN 9..77
FT /note="HTH gntR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT DNA_BIND 37..56
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ SEQUENCE 240 AA; 26969 MW; 3F11CE8A7F564BC8 CRC64;
MQVDKTSFTP LYKQLFFIIC QQIQNGSLPL GSQLPTQKEI ARSYNVSLIV VKQAWSELIN
AGIISSQRGS GSVVCSVPEG VSYGHTFRGI TRDLQDASVA IENRILEIAP RRARDAQADG
LSLPAQHHYL YISRIRCLNN RPFNHEKIYL DLSFFPGLEL TPQALEHTSL YSLLNVTSDS
AIEKVEAILP SADLCEKLQI AANKPLLSVA RQTFQAGKDS PFEYCRYYVL SEYFGEIHYH
