FEND_DROME
ID FEND_DROME Reviewed; 321 AA.
AC Q9GNL3; Q9W387;
DT 31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Transmembrane protein fend;
DE AltName: Full=Protein forked end;
DE Flags: Precursor;
GN Name=fend;
GN Synonyms=ld14 {ECO:0000312|EMBL:AAG43498.1,
GN ECO:0000312|FlyBase:FBgn0030090}; ORFNames=CG12664;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAB83666.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RC TISSUE=Larva {ECO:0000269|PubMed:11984842};
RX PubMed=11984842; DOI=10.1002/neu.10063;
RA Umemiya T., Takasu E., Takeichi M., Aigaki T., Nose A.;
RT "Forked end: a novel transmembrane protein involved in neuromuscular
RT specificity in drosophila identified by gain-of-function screening.";
RL J. Neurobiol. 51:205-214(2002).
RN [2] {ECO:0000312|EMBL:AAG43498.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo {ECO:0000269|Ref.2};
RA Blanca-Postigo J.M., Canizares-Sales J., Navarro-Langa J.A.,
RA Molto-Ruiz M.D.;
RT "ld14 a new gene in 8D.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000312|EMBL:AAF46447.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4] {ECO:0000312|EMBL:AAF46447.2}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5] {ECO:0000312|EMBL:AAG43498.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:ABV82367.1}; TISSUE=Embryo;
RA Stapleton M., Carlson J., Frise E., Kapadia B., Park S., Wan K., Yu C.,
RA Celniker S.;
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the normal targeting of ventral muscle, muscle
CC 12, by motoneurons. May function as an axon guidance molecule involved
CC in neuromuscular specificity. {ECO:0000269|PubMed:11984842}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed strongly throughout the yolk. Later,
CC zygotic expression is confined to the presumptive neurogenic regions.
CC In the CNS, expressed in the ventral nerve cord. Expressed in the PNS
CC including in the lateral chordotonal organs at stages 16-17, expressed
CC in epidermal cells at stages 13-15, and expressed in heart cells at
CC stages 13-17. {ECO:0000269|PubMed:11984842}.
CC -!- DISRUPTION PHENOTYPE: Homozygotes are viable and fertile, display no
CC obvious abnormalities in the development of the CNS, PNS or muscles.
CC However, they exhibit highly specific defects in the innervation
CC pattern of muscle 12, but no obvious defects in the innervation of
CC other muscles. Both loss and gain of function mutants display altered
CC neuromuscular specificity. {ECO:0000269|PubMed:11984842}.
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DR EMBL; AB065095; BAB83666.1; -; mRNA.
DR EMBL; AF209858; AAG43498.1; -; mRNA.
DR EMBL; AE014298; AAF46447.2; -; Genomic_DNA.
DR EMBL; BT030985; ABV82367.1; -; mRNA.
DR RefSeq; NP_001259372.1; NM_001272443.2.
DR RefSeq; NP_572528.1; NM_132300.3.
DR AlphaFoldDB; Q9GNL3; -.
DR BioGRID; 58298; 5.
DR STRING; 7227.FBpp0305496; -.
DR PaxDb; Q9GNL3; -.
DR DNASU; 31843; -.
DR EnsemblMetazoa; FBtr0071349; FBpp0071284; FBgn0030090.
DR EnsemblMetazoa; FBtr0333304; FBpp0305496; FBgn0030090.
DR GeneID; 31843; -.
DR KEGG; dme:Dmel_CG12664; -.
DR UCSC; CG12664-RB; d. melanogaster.
DR CTD; 31843; -.
DR FlyBase; FBgn0030090; fend.
DR VEuPathDB; VectorBase:FBgn0030090; -.
DR eggNOG; ENOG502RJI0; Eukaryota.
DR HOGENOM; CLU_869525_0_0_1; -.
DR InParanoid; Q9GNL3; -.
DR OMA; DIGWDEM; -.
DR OrthoDB; 1254976at2759; -.
DR PhylomeDB; Q9GNL3; -.
DR BioGRID-ORCS; 31843; 0 hits in 1 CRISPR screen.
DR ChiTaRS; fend; fly.
DR GenomeRNAi; 31843; -.
DR PRO; PR:Q9GNL3; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0030090; Expressed in brain and 23 other tissues.
DR ExpressionAtlas; Q9GNL3; baseline and differential.
DR Genevisible; Q9GNL3; DM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008045; P:motor neuron axon guidance; IMP:FlyBase.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..321
FT /note="Transmembrane protein fend"
FT /evidence="ECO:0000255"
FT /id="PRO_0000420127"
FT TOPO_DOM 19..261
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 321 AA; 34626 MW; A31D95B41771A7E9 CRC64;
MFHSLVLMAC ALAALSVAQG AGSARSKSLP LSLSLSVSVS SSLASASSPG AAADPTAAFT
VTATAPTPAS APFAGKQLNR CRQSCYQQLS KDWHYCKDSV DCTNCCQKLV APFELRILKA
QRQESLVLTD IGWDEMIANA SRQCLITWEV SGGGLIGNLL TDTARAELSL WPDTVYNIQV
KCKHKLTGLM RRSIKLNVDT SQLVGTTTTT TTSKSSIQRQ HLEQPVDHTD ALEHSQHIRI
PRPTDRVYII SALPTPSELG GVVYPAFGAL AFFLALLVMF LFLRPQRKRF PLDADSADTA
TLIGRSSSSS RNSMDASTLH V
