FEOA_ECOLI
ID FEOA_ECOLI Reviewed; 75 AA.
AC P0AEL3; P33649; Q2M773;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Fe(2+) transport protein A {ECO:0000305};
DE AltName: Full=Ferrous iron transport protein A;
GN Name=feoA; OrderedLocusNames=b3408, JW3371;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=K12 / MC4100;
RX PubMed=8407793; DOI=10.1128/jb.175.19.6212-6219.1993;
RA Kammler M., Schoen C., Hantke K.;
RT "Characterization of the ferrous iron uptake system of Escherichia coli.";
RL J. Bacteriol. 175:6212-6219(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP INDUCTION BY HYDROXYUREA.
RC STRAIN=K12 / MC4100 / ATCC 35695 / DSM 6574;
RX PubMed=20005847; DOI=10.1016/j.molcel.2009.11.024;
RA Davies B.W., Kohanski M.A., Simmons L.A., Winkler J.A., Collins J.J.,
RA Walker G.C.;
RT "Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia
RT coli.";
RL Mol. Cell 36:845-860(2009).
RN [5] {ECO:0007744|PDB:2LX9}
RP STRUCTURE BY NMR, SUBUNIT, AND SUBCELLULAR LOCATION.
RC STRAIN=K12;
RX PubMed=23104801; DOI=10.1128/jb.01121-12;
RA Lau C.K., Ishida H., Liu Z., Vogel H.J.;
RT "Solution structure of Escherichia coli FeoA and its potential role in
RT bacterial ferrous iron transport.";
RL J. Bacteriol. 195:46-55(2013).
CC -!- FUNCTION: Involved in Fe(2+) ion uptake (PubMed:8407793). Does not
CC stimulate the GTPase activity of the N-terminus of FeoB (residues 1-
CC 276). {ECO:0000269|PubMed:23104801, ECO:0000269|PubMed:8407793}.
CC -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:23104801}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:23104801}.
CC -!- INDUCTION: Induced by hydroxyurea (PubMed:20005847).
CC {ECO:0000269|PubMed:20005847}.
CC -!- DISRUPTION PHENOTYPE: Reduced uptake of Fe(2+).
CC {ECO:0000269|PubMed:8407793}.
CC -!- SIMILARITY: Belongs to the FeoA family. {ECO:0000305}.
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DR EMBL; X71063; CAA50386.1; -; Genomic_DNA.
DR EMBL; U18997; AAA58206.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76433.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77883.1; -; Genomic_DNA.
DR PIR; B36932; B36932.
DR RefSeq; NP_417867.1; NC_000913.3.
DR RefSeq; WP_001200455.1; NZ_SSZK01000008.1.
DR PDB; 2LX9; NMR; -; A=1-75.
DR PDBsum; 2LX9; -.
DR AlphaFoldDB; P0AEL3; -.
DR BMRB; P0AEL3; -.
DR SMR; P0AEL3; -.
DR BioGRID; 4261724; 9.
DR BioGRID; 852218; 2.
DR IntAct; P0AEL3; 4.
DR STRING; 511145.b3408; -.
DR TCDB; 9.A.8.1.1; the ferrous iron uptake (feob) family.
DR PaxDb; P0AEL3; -.
DR PRIDE; P0AEL3; -.
DR EnsemblBacteria; AAC76433; AAC76433; b3408.
DR EnsemblBacteria; BAE77883; BAE77883; BAE77883.
DR GeneID; 67417035; -.
DR GeneID; 947909; -.
DR KEGG; ecj:JW3371; -.
DR KEGG; eco:b3408; -.
DR PATRIC; fig|1411691.4.peg.3321; -.
DR EchoBASE; EB2025; -.
DR eggNOG; COG1918; Bacteria.
DR HOGENOM; CLU_150646_13_0_6; -.
DR InParanoid; P0AEL3; -.
DR OMA; MGDPVQI; -.
DR PhylomeDB; P0AEL3; -.
DR BioCyc; EcoCyc:EG12101-MON; -.
DR EvolutionaryTrace; P0AEL3; -.
DR PRO; PR:P0AEL3; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEP:EcoliWiki.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR Gene3D; 2.30.30.90; -; 1.
DR InterPro; IPR007167; Fe-transptr_FeoA.
DR InterPro; IPR038157; FeoA_core_dom.
DR InterPro; IPR008988; Transcriptional_repressor_C.
DR Pfam; PF04023; FeoA; 1.
DR SMART; SM00899; FeoA; 1.
DR SUPFAM; SSF50037; SSF50037; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Ion transport; Iron; Iron transport;
KW Reference proteome; Transport.
FT CHAIN 1..75
FT /note="Fe(2+) transport protein A"
FT /id="PRO_0000087222"
FT STRAND 8..13
FT /evidence="ECO:0007829|PDB:2LX9"
FT STRAND 16..18
FT /evidence="ECO:0007829|PDB:2LX9"
FT HELIX 20..28
FT /evidence="ECO:0007829|PDB:2LX9"
FT STRAND 33..42
FT /evidence="ECO:0007829|PDB:2LX9"
FT TURN 44..46
FT /evidence="ECO:0007829|PDB:2LX9"
FT STRAND 49..52
FT /evidence="ECO:0007829|PDB:2LX9"
FT STRAND 57..60
FT /evidence="ECO:0007829|PDB:2LX9"
FT HELIX 62..67
FT /evidence="ECO:0007829|PDB:2LX9"
FT STRAND 68..72
FT /evidence="ECO:0007829|PDB:2LX9"
SQ SEQUENCE 75 AA; 8371 MW; 945AC2E01C24CC92 CRC64;
MQYTPDTAWK ITGFSREISP AYRQKLLSLG MLPGSSFNVV RVAPLGDPIH IETRRVSLVL
RKKDLALLEV EAVSC
