FEOB2_PORGI
ID FEOB2_PORGI Reviewed; 725 AA.
AC Q7MVL1;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Fe(2+) transporter FeoB homolog {ECO:0000305};
DE AltName: Full=Ferrous iron transport protein B homolog;
GN Name=feoB2 {ECO:0000303|PubMed:15901729};
GN Synonyms=feoB-1 {ECO:0000303|PubMed:12949112}; OrderedLocusNames=PG_1043;
OS Porphyromonas gingivalis (strain ATCC BAA-308 / W83).
OC Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Porphyromonadaceae;
OC Porphyromonas.
OX NCBI_TaxID=242619;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-308 / W83;
RX PubMed=12949112; DOI=10.1128/jb.185.18.5591-5601.2003;
RA Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E.,
RA Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L.,
RA Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J.,
RA Granger D., Tettelin H., Dong H., Galvin J.L., Duncan M.J., Dewhirst F.E.,
RA Fraser C.M.;
RT "Complete genome sequence of the oral pathogenic bacterium Porphyromonas
RT gingivalis strain W83.";
RL J. Bacteriol. 185:5591-5601(2003).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 53978 / W50;
RX PubMed=15901729; DOI=10.1074/jbc.m503896200;
RA Dashper S.G., Butler C.A., Lissel J.P., Paolini R.A., Hoffmann B.,
RA Veith P.D., O'Brien-Simpson N.M., Snelgrove S.L., Tsiros J.T.,
RA Reynolds E.C.;
RT "A novel Porphyromonas gingivalis FeoB plays a role in manganese
RT accumulation.";
RL J. Biol. Chem. 280:28095-28102(2005).
CC -!- FUNCTION: Not involved in Fe(2+) uptake but is involved in manganese
CC uptake. Could be GTP-driven. {ECO:0000269|PubMed:15901729}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: A 3-fold increase in intracellular manganese
CC levels. {ECO:0000269|PubMed:15901729}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC {ECO:0000255|PROSITE-ProRule:PRU01048}.
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DR EMBL; AE015924; AAQ66162.1; -; Genomic_DNA.
DR AlphaFoldDB; Q7MVL1; -.
DR SMR; Q7MVL1; -.
DR STRING; 242619.PG_1043; -.
DR TCDB; 9.A.8.1.5; the ferrous iron uptake (feob) family.
DR EnsemblBacteria; AAQ66162; AAQ66162; PG_1043.
DR KEGG; pgi:PG_1043; -.
DR eggNOG; COG0370; Bacteria.
DR HOGENOM; CLU_013350_3_0_10; -.
DR OMA; PPYRKPQ; -.
DR Proteomes; UP000000588; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR CDD; cd01879; FeoB; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003373; Fe2_transport_prot-B.
DR InterPro; IPR011640; Fe2_transport_prot_B_C.
DR InterPro; IPR041069; FeoB_Cyto.
DR InterPro; IPR030389; G_FEOB_dom.
DR InterPro; IPR011642; Gate_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF07664; FeoB_C; 1.
DR Pfam; PF17910; FeoB_Cyto; 1.
DR Pfam; PF02421; FeoB_N; 1.
DR Pfam; PF07670; Gate; 2.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00437; feoB; 1.
DR PROSITE; PS51711; G_FEOB; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; GTP-binding; Manganese; Membrane;
KW Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..725
FT /note="Fe(2+) transporter FeoB homolog"
FT /id="PRO_0000210840"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 473..493
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 496..516
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 556..576
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 628..648
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 657..677
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 699..719
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 34..196
FT /note="FeoB-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 41..48
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 66..70
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 87..90
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 147..150
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 176..178
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
SQ SEQUENCE 725 AA; 79476 MW; 8C1F2A0F6F04F0B1 CRC64;
MMKKSATTSS ACNGCPAHSG NKLRRMGTDA ERYDFTIALA GNPNTGKSTV FNALTGLKQH
TGNWPGKTVE KAEGAFSYAG SSYKIVDLPG TYSLLSTSED EEIARDFILF GKPDVTLIVA
DATRLERNMN LILQILEITD RAVLCANLMD EAERNGVEID LRGLSRRLGI PVVGASARSG
EGISDLLSAL SEVAQGIYRC TPHRLTSIGT EIDTRIDSLA ESIRLFHPDT PNSRWLALRL
TEGDRRVENI LYADNEAPAE KLKKEVDEFR RNFGEDLHDQ LSEALYSDAG KICQEVITQA
NKRGRTPLDI KIDRIVTSRK WGFPIMLLML ALVLWITIVG SNYPSQWLSD SLVGILHPLL
KTRATGFLPD WLSGFLIDGV YLATAWVVSV MLPPMAIFFP LFTLLEDFGF LPRVAFNLDE
LFRRSGAHGK QALTMTMGFG CNAAAIINTR IIDSQRERLI AILTNNFSLC NGRWPTQILL
ATIFLTPAVP AYLRGVIGIG SVVAIALLGI AFMFFFSWVL SRTLLRGQVS TFNLELPPYR
PPQFWQTIYK SIVDRTLVVL WRAVVFAAPA GALIWLTCNI QIGGVGIAEY LIDLLDGPGW
LMGLNGVILL AYVLAIPANE IVIPTILMLT VLTTGIDGGT GAGVMFEADG TAETARLFEA
GGWTMLTGIN LMLFCLLHNP CSTTLFNIYK ETGSRKWTLL AALIPLATGF VVTVAVAFVW
RLVGG
