FEOB_CAMJE
ID FEOB_CAMJE Reviewed; 613 AA.
AC Q9PMQ9; Q0P8L6; Q6U206; Q6U6H3;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Fe(2+) transporter FeoB {ECO:0000303|PubMed:16988218};
DE AltName: Full=Ferrous iron transport protein B homolog;
GN Name=feoB; OrderedLocusNames=Cj1398;
OS Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC
OS 11168).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Campylobacteraceae; Campylobacter.
OX NCBI_TaxID=192222;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF
RP 1-609, AND FUNCTION.
RC STRAIN=F38011, and M129;
RX PubMed=14735223; DOI=10.1139/w03-086;
RA Raphael B.H., Joens L.A.;
RT "FeoB is not required for ferrous iron uptake in Campylobacter jejuni.";
RL Can. J. Microbiol. 49:727-731(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700819 / NCTC 11168;
RX PubMed=10688204; DOI=10.1038/35001088;
RA Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A.,
RA Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S.,
RA Barrell B.G.;
RT "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT reveals hypervariable sequences.";
RL Nature 403:665-668(2000).
RN [3]
RP FUNCTION, INDUCTION, OPERON, AND DISRUPTION PHENOTYPE.
RC STRAIN=81-176, ATCC 43431 / TGH 9011 / Serotype O:3, and
RC ATCC 700819 / NCTC 11168;
RX PubMed=16988218; DOI=10.1128/iai.00052-06;
RA Naikare H., Palyada K., Panciera R., Marlow D., Stintzi A.;
RT "Major role for FeoB in Campylobacter jejuni ferrous iron acquisition, gut
RT colonization, and intracellular survival.";
RL Infect. Immun. 74:5433-5444(2006).
CC -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake system
CC across the cell inner membrane into the cytoplasm, shown for strain
CC NCTC 11168 (PubMed:16988218). {ECO:0000269|PubMed:16988218}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P33650}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P33650}.
CC -!- INDUCTION: Detected in iron-restricted, mid-log-phase cells, part of
CC the feoA-feoB operon (strain NCTC 11168).
CC {ECO:0000269|PubMed:16988218}.
CC -!- DISRUPTION PHENOTYPE: Loss of 90% of Fe(2+) uptake into the cytoplasm,
CC reduced growth rate in iron-limited medium, strain NCTC 11168; in iron-
CC rich medium Fe(2+) uptake is not affected (PubMed:16988218). Reduced
CC survival in human and pig epithelial cells after 3 days, strain 81-176
CC (PubMed:16988218). Reduced ability to colonize chick cecum, strains 81-
CC 176, ATCC 43431 and NCTC 11168 (PubMed:16988218). Outcompeted by wild-
CC type bacteria in infection assays in piglets; the 3 different strains
CC colonize different regions of the gut differently (PubMed:16988218).
CC {ECO:0000269|PubMed:16988218}.
CC -!- MISCELLANEOUS: Fe(2+) ion uptake in diverse strains of C.jejuni is much
CC lower than in E.coli and H.pylori. Site-directed mutations in FeoB
CC cause no defect in Fe(2+) uptake.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC {ECO:0000255|PROSITE-ProRule:PRU01048}.
CC -!- CAUTION: Has been reported not to be involved in Fe(2+) uptake in
CC strains F38001 and M129, when the strains were grown in iron-containing
CC medium (PubMed:14735223). When the feoB deletion strain of NCTC 11168
CC is grown in iron-containing medium Fe(2+) uptake occurs, suggesting the
CC prior results in strain F38001 and M129 may not be correct
CC (PubMed:16988218). {ECO:0000269|PubMed:14735223,
CC ECO:0000269|PubMed:16988218}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAR20450.1; Type=Erroneous termination; Note=Truncated C-terminus. Strain F38011 sequence differs due to a recombination event that leads to a 68-bp deletion producing a stop codon at position 544.; Evidence={ECO:0000305};
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DR EMBL; AY380227; AAR20450.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL111168; CAL35507.1; -; Genomic_DNA.
DR EMBL; AY377919; AAQ88281.1; -; Genomic_DNA.
DR PIR; F81284; F81284.
DR RefSeq; WP_002865443.1; NC_002163.1.
DR RefSeq; YP_002344781.1; NC_002163.1.
DR AlphaFoldDB; Q9PMQ9; -.
DR SMR; Q9PMQ9; -.
DR STRING; 192222.Cj1398; -.
DR PaxDb; Q9PMQ9; -.
DR PRIDE; Q9PMQ9; -.
DR EnsemblBacteria; CAL35507; CAL35507; Cj1398.
DR GeneID; 905687; -.
DR KEGG; cje:Cj1398; -.
DR PATRIC; fig|192222.6.peg.1379; -.
DR eggNOG; COG0370; Bacteria.
DR HOGENOM; CLU_013350_3_2_7; -.
DR OMA; PLGYDWK; -.
DR Proteomes; UP000000799; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR CDD; cd01879; FeoB; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003373; Fe2_transport_prot-B.
DR InterPro; IPR011640; Fe2_transport_prot_B_C.
DR InterPro; IPR030389; G_FEOB_dom.
DR InterPro; IPR011642; Gate_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR Pfam; PF07664; FeoB_C; 1.
DR Pfam; PF02421; FeoB_N; 1.
DR Pfam; PF07670; Gate; 2.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00437; feoB; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51711; G_FEOB; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cell inner membrane; Cell membrane; GTP-binding;
KW Ion transport; Iron; Iron transport; Membrane; Nucleotide-binding;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..613
FT /note="Fe(2+) transporter FeoB"
FT /id="PRO_0000210829"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..342
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 444..464
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 510..530
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 556..576
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 587..607
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 3..165
FT /note="FeoB-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 10..17
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 35..39
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 56..59
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 116..119
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 145..147
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT VARIANT 132
FT /note="I -> V (in strain: F38011)"
FT VARIANT 254
FT /note="T -> A (in strain: F38011 and M129)"
FT VARIANT 258
FT /note="F -> L (in strain: M129)"
FT VARIANT 291
FT /note="M -> I (in strain: M129)"
FT VARIANT 469
FT /note="S -> N (in strain: M129)"
FT VARIANT 500
FT /note="Q -> K (in strain: F38011 and M129)"
FT VARIANT 605
FT /note="L -> F (in strain: M129)"
SQ SEQUENCE 613 AA; 69036 MW; 9E34139AE9E376BC CRC64;
MKKIKIALVG QPNVGKSLLI NALCKANMKV GNFSGVTIEK ASAKTFYKNY EFEVIDLPGT
YSLDGYSEEE KITRHFLNQN DYDVIVNVLD ATNLERNLIL SAELLSLNKK MLLALNMCDE
AKKEGIELDT SILSQEFQSQ VVEISAKTKE NLELLLQKII ILFESKFIPR SQFYTPLCEK
SPEKEDLLYF INELSKKIIT HKKEERNLTK KIDALLIHKF FGLPIFLFLM WLLFQLTFSL
GQIPMDYIES GFNTLGEFVK NNISNTFIAS ALADGIIAGV GAVILFLPNI MILFLGIALL
ETTGYMSRVA FLLDGILHKF GLHGKSFIPL ITGFGCSVPA FMATRTLKNK RDRLLTLFVI
NFMSCGARLP VYVLFIGAFF PSEKAGNYLF GIYILGAILG LCAAKFLRMT AFRGLDEPFV
MEMPKYRMPN WHLVWFMVYN KAKMYLKKAG TFILLASLLI WFASNFPKSE ENLNDFNAQE
RAIEQSYLGQ FGKGIEPIFQ PLELDWKLSV SLISGLAAKE VMISTMGVLY SLGKDVDETN
NDLKGIIAKN IPIPSAVAFI LFVMIYNPCF AATIVFSKES GKLKYTLFLF LFTCTSAYIV
AFIGLHIAKI LLN