FEOB_HELPY
ID FEOB_HELPY Reviewed; 642 AA.
AC O25396;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Fe(2+) transporter FeoB {ECO:0000305};
DE AltName: Full=Ferrous iron transport protein B;
GN Name=feoB; OrderedLocusNames=HP_0687;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 43504 / NCTC 11637 / JCM 7653 / RPH 13487;
RX PubMed=10931324; DOI=10.1046/j.1365-2958.2000.01987.x;
RA Velayudhan J., Hughes N.J., McColm A.A., Bagshaw J., Clayton C.L.,
RA Andrews S.C., Kelly D.J.;
RT "Iron acquisition and virulence in Helicobacter pylori: a major role for
RT FeoB, a high-affinity ferrous iron transporter.";
RL Mol. Microbiol. 37:274-286(2000).
CC -!- FUNCTION: Probable transporter of an ATP-driven Fe(2+) uptake system.
CC {ECO:0000269|PubMed:10931324}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P33650}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P33650}.
CC -!- DISRUPTION PHENOTYPE: Cells are unable to colonize the gastric mucosa
CC of mice. {ECO:0000269|PubMed:10931324}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC {ECO:0000255|PROSITE-ProRule:PRU01048}.
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DR EMBL; AE000511; AAD07741.1; -; Genomic_DNA.
DR PIR; G64605; G64605.
DR RefSeq; NP_207481.1; NC_000915.1.
DR RefSeq; WP_000659176.1; NC_018939.1.
DR AlphaFoldDB; O25396; -.
DR SMR; O25396; -.
DR DIP; DIP-3079N; -.
DR IntAct; O25396; 19.
DR MINT; O25396; -.
DR STRING; 85962.C694_03545; -.
DR TCDB; 9.A.8.1.2; the ferrous iron uptake (feob) family.
DR PaxDb; O25396; -.
DR EnsemblBacteria; AAD07741; AAD07741; HP_0687.
DR KEGG; hpy:HP_0687; -.
DR PATRIC; fig|85962.47.peg.736; -.
DR eggNOG; COG0370; Bacteria.
DR OMA; PLGYDWK; -.
DR PhylomeDB; O25396; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR CDD; cd01879; FeoB; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003373; Fe2_transport_prot-B.
DR InterPro; IPR011640; Fe2_transport_prot_B_C.
DR InterPro; IPR030389; G_FEOB_dom.
DR InterPro; IPR011642; Gate_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF07664; FeoB_C; 1.
DR Pfam; PF02421; FeoB_N; 1.
DR Pfam; PF07670; Gate; 2.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00437; feoB; 1.
DR PROSITE; PS51711; G_FEOB; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; GTP-binding;
KW Ion transport; Iron; Iron transport; Membrane; Nucleotide-binding;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..642
FT /note="Fe(2+) transporter FeoB"
FT /id="PRO_0000210830"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 388..408
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..467
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 541..561
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 586..606
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 615..635
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 3..168
FT /note="FeoB-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 10..17
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 35..39
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 56..59
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 116..119
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 145..147
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
SQ SEQUENCE 642 AA; 71423 MW; D6784C7153E8A3BC CRC64;
MKEITIALVG QPNVGKSSLI NALSNAHLKV GNFAGVTVDK MEVGLIHKEH QITIIDLPGT
YALNDFTTEE KVTKDFLEKG QYDLILNVVD STNLERNLAL SAQLLDTNKK MLLALNMWDE
AQKEGIKINT EKLSKELGVV CVPTSARSKE DRLNTELLLD EIVRLYSQNT TNNENIKVPS
QSFKESLKYS QSAQRIAQLV ISENQQNASF EHTYKIDKIL MHKRYGIFIF LGFMFIIFSL
SFLIGGGVQK ALETGFKFLS DGIKENVANE DLASLVGDGI IGGVGATVSF LPLIVVLYFG
ISLLETTGYM SRVAFLLDGI LHKFGLHGKS FIPLITGFGC SVPAYMATRT LQNYNERLIT
LFVIGFMSCS ARLPIYVLFV GSFFPSSSAG FVLFCIYILG AVVALVMAKL LKLSVFKGQT
ESFIMEMPKY RFPSWRMVYF SIYTKSLSYL KKAGTYILVG AILIWFMSQY PKSDAAMKAY
KQESLLVNKD TTLSSEAKEE KLKELKTELD KKNLKNSIVG RGGAYLEKVF SPMDFDWRLS
VSLVTGFMAK EVVVSTLGVL FSLGDQNEKS DAFRGILRKE VSVPSGIAFI VFVMFYIPCF
AATITFGREA GGIKFVAYLF IFTTVVAYAF SLIAFYATQI LV
