ID   FEOB_LEGPN              Reviewed;         751 AA.
AC   Q8GNS3;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Fe(2+) transporter FeoB {ECO:0000305};
DE   AltName: Full=Ferrous iron transport protein B;
GN   Name=feoB;
OS   Legionella pneumophila.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=446;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=130b / Wadsworth / Serogroup 1;
RX   PubMed=12228295; DOI=10.1128/iai.70.10.5659-5669.2002;
RA   Robey M., Cianciotto N.P.;
RT   "Legionella pneumophila feoAB promotes ferrous iron uptake and
RT   intracellular infection.";
RL   Infect. Immun. 70:5659-5669(2002).
CC   -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake system.
CC       Seems to be required for optimal intracellular infection of
CC       macrophages, to be important for growth and/or survival in iron-
CC       restricted amoebae. It also plays a key role in extracellular growth
CC       under iron-limited conditions. {ECO:0000269|PubMed:12228295}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P33650}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P33650}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01048}.
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DR   EMBL; AF492466; AAN17185.1; -; Genomic_DNA.
DR   RefSeq; WP_038839664.1; NZ_UGOS01000001.1.
DR   PDB; 3IBY; X-ray; 2.50 A; A/B/C/D=1-256.
DR   PDBsum; 3IBY; -.
DR   AlphaFoldDB; Q8GNS3; -.
DR   SMR; Q8GNS3; -.
DR   STRING; 91892.BIZ52_13845; -.
DR   eggNOG; COG0370; Bacteria.
DR   OrthoDB; 304844at2; -.
DR   EvolutionaryTrace; Q8GNS3; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00437; feoB; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell inner membrane; Cell membrane; GTP-binding;
KW   Ion transport; Iron; Iron transport; Membrane; Nucleotide-binding;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..751
FT                   /note="Fe(2+) transporter FeoB"
FT                   /id="PRO_0000210832"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        385..405
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        422..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        447..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        512..532
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        539..559
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        657..677
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        685..705
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        715..735
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1..167
FT                   /note="FeoB-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         8..15
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         33..37
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         54..57
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         118..121
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   BINDING         147..149
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   STRAND          3..9
FT                   /evidence="ECO:0007829|PDB:3IBY"
FT   HELIX           14..22
FT                   /evidence="ECO:0007829|PDB:3IBY"
FT   STRAND          25..30
FT                   /evidence="ECO:0007829|PDB:3IBY"
FT   STRAND          34..45
FT                   /evidence="ECO:0007829|PDB:3IBY"
FT   STRAND          48..54
FT                   /evidence="ECO:0007829|PDB:3IBY"
FT   STRAND          65..67
FT                   /evidence="ECO:0007829|PDB:3IBY"
FT   HELIX           70..81
FT                   /evidence="ECO:0007829|PDB:3IBY"
FT   STRAND          85..92
FT                   /evidence="ECO:0007829|PDB:3IBY"
FT   HELIX           93..95
FT                   /evidence="ECO:0007829|PDB:3IBY"
FT   HELIX           96..106
FT                   /evidence="ECO:0007829|PDB:3IBY"
FT   STRAND          113..118
FT                   /evidence="ECO:0007829|PDB:3IBY"
FT   HELIX           120..125
FT                   /evidence="ECO:0007829|PDB:3IBY"
FT   HELIX           132..139
FT                   /evidence="ECO:0007829|PDB:3IBY"
FT   STRAND          143..145
FT                   /evidence="ECO:0007829|PDB:3IBY"
FT   HELIX           148..150
FT                   /evidence="ECO:0007829|PDB:3IBY"
FT   HELIX           154..162
FT                   /evidence="ECO:0007829|PDB:3IBY"
FT   HELIX           177..193
FT                   /evidence="ECO:0007829|PDB:3IBY"
FT   HELIX           197..209
FT                   /evidence="ECO:0007829|PDB:3IBY"
FT   HELIX           214..217
FT                   /evidence="ECO:0007829|PDB:3IBY"
FT   HELIX           219..229
FT                   /evidence="ECO:0007829|PDB:3IBY"
FT   HELIX           234..253
FT                   /evidence="ECO:0007829|PDB:3IBY"
SQ   SEQUENCE   751 AA;  82514 MW;  46DB2FD7C9986192 CRC64;
     MTHALLIGNP NCGKTTLFNA LTNANQRVGN WPGVTVEKKT GEFLLGEHLI EITDLPGVYS
     LVANAEGISQ DEQIAAQSVI DLEYDCIINV IDACHLERHL YLTSQLFELG KPVVVALNMM
     DIAEHRGISI DTEKLESLLG CSVIPIQAHK NIGIPALQQS LLHCSQKIKP LKLSLSVAAQ
     QILNDLENQL ISKGYKNSFA YYFSRRLAEG DTLIGEKAFT ESLLIKLQET EQNLDVLLAD
     ARYQKIHEIV TLVQKKHSDA SEHFTAKLDK LVLHRFLALP IFFAMMYLMF LFAINIGGAF
     QDFFDISTET IFVQGSGWLL QQLHAPNWVI ALVANGVGKG INTTITFIPV IAAMFFFLSL
     LETSGYMARA AFVVDKAMRA MGLPGKSFVP MIVGFGCNVP AIMAARTLDS ERDRLLTVMM
     SPFMSCSARL AIYAVFVAAF FPSGGHNVVF SLYLIGILMA VFTGYILRKT TLKGHASPLI
     LELPAYHRPS LRRLLRETSL RLRFFVYRAG KLIIPICVIL GGLNAITWGG GISSGEANTD
     SLLSIIGQWI TPLFAPMGIH QDNWPATVGL LTGMLAKEVV VGTLNSLYAQ VGHVGEITAA
     HFDFWGGIKA AFGSIPANLS ELGSALWNPV SASAADSELS QSVYGIMSRR FDGAVGAYAY
     LLFVLLYIPC VSTMAVIRQE ANKRFMWTSI VWSFVVAYAT SVVFYQGAKF LDHPQQSMVW
     ILAMSLSLLF VLAVFRYSQY GMGRQNAAAN T