FEOB_LEPBP
ID FEOB_LEPBP Reviewed; 690 AA.
AC Q5XPH7; B0SLV2;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Fe(2+) transporter FeoB {ECO:0000305};
DE AltName: Full=Ferrous iron transport protein B;
GN Name=feoB; OrderedLocusNames=LEPBI_I0879;
OS Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris).
OC Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX NCBI_TaxID=456481;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Patoc I / Serovar Patoc;
RX PubMed=15838052; DOI=10.1128/jb.187.9.3249-3254.2005;
RA Louvel H., Saint Girons I., Picardeau M.;
RT "Isolation and characterization of FecA- and FeoB-mediated iron acquisition
RT systems of the spirochete Leptospira biflexa by random insertional
RT mutagenesis.";
RL J. Bacteriol. 187:3249-3254(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Patoc 1 / ATCC 23582 / Paris;
RX PubMed=18270594; DOI=10.1371/journal.pone.0001607;
RA Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N.,
RA Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A.,
RA Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L.,
RA Rood J.I., Lajus A., Davies J.K., Medigue C., Adler B.;
RT "Genome sequence of the saprophyte Leptospira biflexa provides insights
RT into the evolution of Leptospira and the pathogenesis of leptospirosis.";
RL PLoS ONE 3:E1607-E1607(2008).
CC -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake system.
CC {ECO:0000250|UniProtKB:Q8GNS3}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P33650}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P33650}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC {ECO:0000255|PROSITE-ProRule:PRU01048}.
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DR EMBL; AY744289; AAU93398.1; -; Genomic_DNA.
DR EMBL; CP000786; ABZ97004.1; -; Genomic_DNA.
DR RefSeq; WP_012387888.1; NC_010602.1.
DR AlphaFoldDB; Q5XPH7; -.
DR SMR; Q5XPH7; -.
DR STRING; 456481.LEPBI_I0879; -.
DR TCDB; 9.A.8.1.4; the ferrous iron uptake (feob) family.
DR KEGG; lbi:LEPBI_I0879; -.
DR HOGENOM; CLU_013350_3_2_12; -.
DR OMA; PLGYDWK; -.
DR OrthoDB; 304844at2; -.
DR BioCyc; LBIF456481:LEPBI_RS04305-MON; -.
DR Proteomes; UP000001847; Chromosome I.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR CDD; cd01879; FeoB; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003373; Fe2_transport_prot-B.
DR InterPro; IPR011640; Fe2_transport_prot_B_C.
DR InterPro; IPR030389; G_FEOB_dom.
DR InterPro; IPR011642; Gate_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF07664; FeoB_C; 1.
DR Pfam; PF02421; FeoB_N; 1.
DR Pfam; PF07670; Gate; 2.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00437; feoB; 1.
DR PROSITE; PS51711; G_FEOB; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; GTP-binding; Ion transport; Iron;
KW Iron transport; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..690
FT /note="Fe(2+) transporter FeoB"
FT /id="PRO_0000210836"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 434..454
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 459..479
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 516..536
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 623..643
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 670..690
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 3..166
FT /note="FeoB-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 10..17
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 35..40
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 56..59
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
SQ SEQUENCE 690 AA; 77649 MW; 8D1D9E1432E9255C CRC64;
MKEKNIYLVG NPNCGKTTLF NQLTGLNQKT GNFSGVTVEK KEGVVYLPNL ELKITDLPGT
YGLGGIAEDK KIAYEVLLKR KENEVVIYVL DALNLERGLQ FLLQIIDMGV PTLVVLTMKD
VLEKKRIQLD LKKLKHSLGL EIVLVNAKSG EGISELKTLL SKEESYRKQK RLWTWGSKEE
SFLTSLKQKL KITTNEAEFF LSQALKFLNH DPHLQDSRYL NQFPNETKQF LTKELESKPL
QFAYQEEMIH RSILIKKIIS ETIHYPIAIQ GSWEERLDRI FLHPILGFVC FFLLMGLLFQ
SLFSFAEIPM DLIEEGITGL QETIGNVLSD GPLKSLLIEG ILGGVGSVVV FVPQIALLFL
FIGILEESGY LARASFLMDR LMGKFGLSGK SFIPLLSSAA CAVPAILGTR TIENKSDRFT
TIMVSPLIMC SARYPVYILI VGTVFSYPPI FGIFNVQGFV LFSMFFLGMI VSFTFALIFR
KTVFKENASY FVMELPRYNL PSFKSLFFTV YGKVKSFLAT AGQIILYISV ILWFLSHFPA
EYKDNVWKTS PIETSYIGRV GKVMEPAIEP LGFDWKIGIS ILTSFAAREV MVSTLAVLYG
SEEEGEESES LRETLRADKK PDGSPVWTPL TGLSLLLFFA FASQCMSTLA VTKKETGSLL
WPTVQFLYMT TLAIFTSFLV FQLGKILGFV
