FEOB_LEPIC
ID FEOB_LEPIC Reviewed; 701 AA.
AC Q72SI0;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Fe(2+) transporter FeoB {ECO:0000305};
DE AltName: Full=Ferrous iron transport protein B;
GN Name=feoB; OrderedLocusNames=LIC_11402;
OS Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni
OS (strain Fiocruz L1-130).
OC Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX NCBI_TaxID=267671;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fiocruz L1-130;
RX PubMed=15028702; DOI=10.1128/jb.186.7.2164-2172.2004;
RA Nascimento A.L.T.O., Ko A.I., Martins E.A.L., Monteiro-Vitorello C.B.,
RA Ho P.L., Haake D.A., Verjovski-Almeida S., Hartskeerl R.A., Marques M.V.,
RA Oliveira M.C., Menck C.F.M., Leite L.C.C., Carrer H., Coutinho L.L.,
RA Degrave W.M., Dellagostin O.A., El-Dorry H., Ferro E.S., Ferro M.I.T.,
RA Furlan L.R., Gamberini M., Giglioti E.A., Goes-Neto A., Goldman G.H.,
RA Goldman M.H.S., Harakava R., Jeronimo S.M.B., Junqueira-de-Azevedo I.L.M.,
RA Kimura E.T., Kuramae E.E., Lemos E.G.M., Lemos M.V.F., Marino C.L.,
RA Nunes L.R., de Oliveira R.C., Pereira G.G., Reis M.S., Schriefer A.,
RA Siqueira W.J., Sommer P., Tsai S.M., Simpson A.J.G., Ferro J.A.,
RA Camargo L.E.A., Kitajima J.P., Setubal J.C., Van Sluys M.A.;
RT "Comparative genomics of two Leptospira interrogans serovars reveals novel
RT insights into physiology and pathogenesis.";
RL J. Bacteriol. 186:2164-2172(2004).
CC -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake system.
CC {ECO:0000250|UniProtKB:Q8GNS3}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P33650}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P33650}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC {ECO:0000255|PROSITE-ProRule:PRU01048}.
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DR EMBL; AE016823; AAS70002.1; -; Genomic_DNA.
DR AlphaFoldDB; Q72SI0; -.
DR SMR; Q72SI0; -.
DR PaxDb; Q72SI0; -.
DR EnsemblBacteria; AAS70002; AAS70002; LIC_11402.
DR KEGG; lic:LIC_11402; -.
DR HOGENOM; CLU_013350_3_2_12; -.
DR OMA; PLGYDWK; -.
DR Proteomes; UP000007037; Chromosome I.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR CDD; cd01879; FeoB; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003373; Fe2_transport_prot-B.
DR InterPro; IPR011640; Fe2_transport_prot_B_C.
DR InterPro; IPR030389; G_FEOB_dom.
DR InterPro; IPR011642; Gate_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF07664; FeoB_C; 1.
DR Pfam; PF02421; FeoB_N; 1.
DR Pfam; PF07670; Gate; 2.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00437; feoB; 1.
DR PROSITE; PS51711; G_FEOB; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; GTP-binding; Ion transport; Iron;
KW Iron transport; Membrane; Nucleotide-binding; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..701
FT /note="Fe(2+) transporter FeoB"
FT /id="PRO_0000210837"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 394..414
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 466..486
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 523..543
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 645..665
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 672..692
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 9..172
FT /note="FeoB-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 16..23
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 41..46
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 62..65
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
SQ SEQUENCE 701 AA; 78133 MW; 15EE6A424F694287 CRC64;
MGHSDSSKTF RILMAGNPNC GKSTLFNQLT GLRQKTGNYH GVTVEKAEGI FHHLDHSVKI
LDLPGAFSLG GSSEDKQITS RVLIGHEAGD RILFVMDASL AERSLQFLLQ ILELNVPVLV
AVTMKDVLEK KRVQLRLDLL SNEFGILFQY VNPKNGEGIK ELKDRIVSPK AFCLPIRSFP
WDSERENFLN DLLNSLSTEH SNSLKFVLTN SLKELSGEIL QKGLPGLSLF SETPSKLIRE
KFERFGKRFT YLEELTQKSI YIKKILSTAI VGDPIPNERV LSKADKILLH PFWGLVSFLG
IMALVFQALF TWSEMPMDWI ESCVRNVGTF VGDFLEEGPL RSLIQEGIIG GVGAVLVFIP
QISLLFLFIG ILEETGYIAR ASFVMDRFMG KFGLSGKSFI PLLSSAACAV PAIMGTRTIE
NKSDRLTTIL VSPLITCSAR YPVYVLVIGA IFPSKNILGI FNVQALTMFG LFLLGMIASM
FAALVFKKTF FKSDSSYFLM ELPAYNTPSI KSLALTVFKK LKAFLSTAGQ IILFISILLW
FLANYPRIDS SLYPNLTDAE LKKIQIRESY AGHSGKFMEP VLKPIGFDWK MGIGIITSFA
AREIMVSTLS IIYGVGGEES TDDLKEALLK DTDENGKPVW GLSNSVSLLL FFAFACQCMS
TLAVVKKETN SIFWPLFLFT YMTILAYSTS FIVFQVWQLF S
