ID   AIS_SALTY               Reviewed;         201 AA.
AC   Q8ZNF4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Lipopolysaccharide core heptose(II)-phosphate phosphatase;
DE            EC=3.1.3.-;
DE   AltName: Full=Polymyxin resistance protein PmrG;
DE   Flags: Precursor;
GN   Name=ais; Synonyms=pagH, pmrG; OrderedLocusNames=STM2296;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   INDUCTION BY BASR.
RC   STRAIN=ATCC 14028s / SGSG 2262;
RX   PubMed=10480935; DOI=10.1074/jbc.274.38.27185;
RA   Woesten M.M.S.M., Groisman E.A.;
RT   "Molecular characterization of the PmrA regulon.";
RL   J. Biol. Chem. 274:27185-27190(1999).
RN   [3]
RP   FUNCTION, INDUCTION BY BASR, AND SUBCELLULAR LOCATION.
RC   STRAIN=ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023;
RX   PubMed=16803591; DOI=10.1111/j.1365-2958.2006.05273.x;
RA   Nishino K., Hsu F.-F., Turk J., Cromie M.J., Woesten M.M.S.M.,
RA   Groisman E.A.;
RT   "Identification of the lipopolysaccharide modifications controlled by the
RT   Salmonella PmrA/PmrB system mediating resistance to Fe(III) and Al(III).";
RL   Mol. Microbiol. 61:645-654(2006).
CC   -!- FUNCTION: Catalyzes the dephosphorylation of heptose(II) of the outer
CC       membrane lipopolysaccharide core. Required for iron(3+) resistance.
CC       {ECO:0000269|PubMed:16803591}.
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC       metabolism.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:16803591}.
CC   -!- INDUCTION: Induced by BasR. {ECO:0000269|PubMed:10480935,
CC       ECO:0000269|PubMed:16803591}.
CC   -!- SIMILARITY: Belongs to the phosphoglycerate mutase family. Ais
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AE006468; AAL21197.1; -; Genomic_DNA.
DR   RefSeq; NP_461238.1; NC_003197.2.
DR   RefSeq; WP_000879248.1; NC_003197.2.
DR   AlphaFoldDB; Q8ZNF4; -.
DR   SMR; Q8ZNF4; -.
DR   STRING; 99287.STM2296; -.
DR   PaxDb; Q8ZNF4; -.
DR   EnsemblBacteria; AAL21197; AAL21197; STM2296.
DR   GeneID; 1253818; -.
DR   KEGG; stm:STM2296; -.
DR   PATRIC; fig|99287.12.peg.2430; -.
DR   HOGENOM; CLU_106705_1_0_6; -.
DR   OMA; NFTVIVW; -.
DR   PhylomeDB; Q8ZNF4; -.
DR   BioCyc; SENT99287:STM2296-MON; -.
DR   UniPathway; UPA00451; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0016791; F:phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008653; P:lipopolysaccharide metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.1240; -; 1.
DR   HAMAP; MF_01868; Ais; 1.
DR   InterPro; IPR013078; His_Pase_superF_clade-1.
DR   InterPro; IPR029033; His_PPase_superfam.
DR   InterPro; IPR011310; LipoPS_heptP_Pase.
DR   Pfam; PF00300; His_Phos_1; 1.
DR   PIRSF; PIRSF011416; Ais-TraG-AfrS; 1.
DR   SUPFAM; SSF53254; SSF53254; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Periplasm; Reference proteome; Signal.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..201
FT                   /note="Lipopolysaccharide core heptose(II)-phosphate
FT                   phosphatase"
FT                   /id="PRO_0000380586"
SQ   SEQUENCE   201 AA;  22027 MW;  A34132FD78210504 CRC64;
     MLAFTLRFIK NKRYFAILAG ALVIIAGLTS QHAWSGNGLP QINGKALAAL AKQHPVVVLF
     RHAERCDRSD NTCLSDSTGI TVKGAQDARA LGKAFSADIQ NYNLYSSNTV RTIQSATWFS
     AGRSLTVDKK MMDCGSGIYA SINTLLKKSQ NKNIVIFTHN HCLTYIAKNK RGVKFDPDYL
     NALVMHAENG KLFLDGEFVP G